ChemicalBook > CAS DataBase List > 2,4,7-TRICHLOROQUINAZOLINE

2,4,7-TRICHLOROQUINAZOLINE

Product Name: 2,4,7-TRICHLOROQUINAZOLINE
CAS No.: 6625-94-1
Chemical Name: 2,4,7-TRICHLOROQUINAZOLINE
Synonyms: 2,4,7-TRICHLOROQUINAZOLINE;Quinazoline, 2,4,7-trichloro-;2,4-Dichloro-7-chloroquinazoline;2,4,7-trichloroquinazoline - [T87191];2,4,7-Trichloroquinazoline, 80% tech grade
CBNumber: CB91502502
Molecular Formula: C8H3Cl3N2
Formula Weight: 233.48
MOL File: 6625-94-1.mol

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2,4,7-TRICHLOROQUINAZOLINE Property

Melting point:: 127 °C
Boiling point:: 309.1±24.0 °C(Predicted)
Density: 1.600±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.14±0.30(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T774728
Product name: 2,4,7-Trichloroquinazoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T774728
Product name: 2,4,7-Trichloroquinazoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W7726
Product name: 2,4,7-Trichloroquinazoline
Packaging: 5g
Price: $289
Updated: 2021/12/16

Matrix Scientific

Product number: 188767
Product name: 2,4,7-Trichloroquinazoline
Packaging: 5g
Price: $676
Updated: 2021/12/16

Matrix Scientific

Product number: 188767
Product name: 2,4,7-Trichloroquinazoline
Packaging: 10g
Price: $1080
Updated: 2021/12/16

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2,4,7-TRICHLOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

13165-35-0

6625-94-1

Step B: Preparation of 2,4,7-trichloroquinazoline. 7-Chloro-1H-quinazoline-2,4-dione (2.0 g, 10 mmol) was suspended in acetonitrile (ACN, 50 mL), followed by the addition of phosphorus oxychloride (POCl3, 5.0 mL, 55 mmol) and diisopropylethylamine (DIEA, 5.0 mL, 28 mmol). The reaction mixture was heated to reflux for 36 hours. Upon completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The residue was carefully quenched with ice water and sodium bicarbonate solution. The resulting solid product was collected by filtration and dried. Finally, purification by column chromatography (eluent: ethyl acetate/hexane, 0:100 to 10:90) afforded the target compound 2,4,7-trichloroquinazoline (2.1 g, 89% yield). The mass spectrometry (MS) and nuclear magnetic resonance (NMR) data were consistent with those reported in the literature (Bioorganic and Medicinal Chemistry, 2003, 11, 2439-2444).1H NMR (400 MHz, DMSO-d6) δ: 8.32 (d, J = 8.7 Hz, 1H), 8.20 (d, J = 1.9 Hz, 1H), 7.93 (dd, J = 9.0, 2.1 Hz, 1H).

References

[1] Pharmaceutical Chemistry Journal, 1987, vol. 21, # 7, p. 478 - 483
[2] Khimiko-Farmatsevticheskii Zhurnal, 1987, vol. 21, # 7, p. 802 - 807
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 15, p. 7268 - 7274
[5] Patent: US2010/204226, 2010, A1. Location in patent: Page/Page column 22

2,4,7-TRICHLOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4,7-TRICHLOROQUINAZOLINE manufacturers

Career Henan Chemical Co

Product: 2,4,7-Trichloroquinazoline 6625-94-1
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

6625-94-1, 2,4,7-TRICHLOROQUINAZOLINERelated Search:

4,7-Dichloroquinazoline 2,4,7-TRICHLOROQUINAZOLINE

2,4,7-TRICHLOROQUINAZOLINE

2,4-Dichloro-7-chloroquinazoline

Quinazoline, 2,4,7-trichloro-

2,4,7-Trichloroquinazoline, 80% tech grade

2,4,7-trichloroquinazoline - [T87191]

6625-94-1