2,4,7-TRICHLOROQUINAZOLINE
- Product Name
- 2,4,7-TRICHLOROQUINAZOLINE
- CAS No.
- 6625-94-1
- Chemical Name
- 2,4,7-TRICHLOROQUINAZOLINE
- Synonyms
- 2,4,7-TRICHLOROQUINAZOLINE;Quinazoline, 2,4,7-trichloro-;2,4-Dichloro-7-chloroquinazoline;2,4,7-trichloroquinazoline - [T87191];2,4,7-Trichloroquinazoline, 80% tech grade
- CBNumber
- CB91502502
- Molecular Formula
- C8H3Cl3N2
- Formula Weight
- 233.48
- MOL File
- 6625-94-1.mol
2,4,7-TRICHLOROQUINAZOLINE Property
- Melting point:
- 127 °C
- Boiling point:
- 309.1±24.0 °C(Predicted)
- Density
- 1.600±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.14±0.30(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T774728
- Product name
- 2,4,7-Trichloroquinazoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T774728
- Product name
- 2,4,7-Trichloroquinazoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W7726
- Product name
- 2,4,7-Trichloroquinazoline
- Packaging
- 5g
- Price
- $289
- Updated
- 2021/12/16
- Product number
- 188767
- Product name
- 2,4,7-Trichloroquinazoline
- Packaging
- 5g
- Price
- $676
- Updated
- 2021/12/16
- Product number
- 188767
- Product name
- 2,4,7-Trichloroquinazoline
- Packaging
- 10g
- Price
- $1080
- Updated
- 2021/12/16
2,4,7-TRICHLOROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
13165-35-0
6625-94-1
Step B: Preparation of 2,4,7-trichloroquinazoline. 7-Chloro-1H-quinazoline-2,4-dione (2.0 g, 10 mmol) was suspended in acetonitrile (ACN, 50 mL), followed by the addition of phosphorus oxychloride (POCl3, 5.0 mL, 55 mmol) and diisopropylethylamine (DIEA, 5.0 mL, 28 mmol). The reaction mixture was heated to reflux for 36 hours. Upon completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The residue was carefully quenched with ice water and sodium bicarbonate solution. The resulting solid product was collected by filtration and dried. Finally, purification by column chromatography (eluent: ethyl acetate/hexane, 0:100 to 10:90) afforded the target compound 2,4,7-trichloroquinazoline (2.1 g, 89% yield). The mass spectrometry (MS) and nuclear magnetic resonance (NMR) data were consistent with those reported in the literature (Bioorganic and Medicinal Chemistry, 2003, 11, 2439-2444).1H NMR (400 MHz, DMSO-d6) δ: 8.32 (d, J = 8.7 Hz, 1H), 8.20 (d, J = 1.9 Hz, 1H), 7.93 (dd, J = 9.0, 2.1 Hz, 1H).
References
[1] Pharmaceutical Chemistry Journal, 1987, vol. 21, # 7, p. 478 - 483
[2] Khimiko-Farmatsevticheskii Zhurnal, 1987, vol. 21, # 7, p. 802 - 807
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 15, p. 7268 - 7274
[5] Patent: US2010/204226, 2010, A1. Location in patent: Page/Page column 22
2,4,7-TRICHLOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,4,7-TRICHLOROQUINAZOLINE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 2,4,7-TRICHLOROQUINAZOLINE manufacturers
- Product
- 2,4,7-Trichloroquinazoline 6625-94-1
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09