4,7-Dichloroquinazoline
- Product Name
- 4,7-Dichloroquinazoline
- CAS No.
- 2148-57-4
- Chemical Name
- 4,7-Dichloroquinazoline
- Synonyms
- 4,7-Dichloroquizoline;7-dichloroquinazoline;4,7-DICHLOROQUINAZOLINE;Quinazoline, 4,7-dichloro-;4,7-
Dichloroquinazoline;4,7-dichloro-4a,8a-dihydroquinazoline - CBNumber
- CB3358665
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 2148-57-4.mol
4,7-Dichloroquinazoline Property
- Melting point:
- 135-136 °C
- Boiling point:
- 317.6±22.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.12±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S671487
- Product name
- 4,7-Dichloroquinazoline
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S671487
- Product name
- 4,7-Dichloroquinazoline
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $110
- Updated
- 2024/03/01
- Product number
- D438553
- Product name
- 4,7-Dichloroquinazoline
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W008281
- Product name
- 4,7-Dichloroquinazoline
- Purity
- 99.37%
- Packaging
- 5g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- CS-W008281
- Product name
- 4,7-Dichloroquinazoline
- Purity
- 99.37%
- Packaging
- 1g
- Price
- $33
- Updated
- 2021/12/16
4,7-Dichloroquinazoline Chemical Properties,Usage,Production
Uses
4,7-Dichloroquinazoline is a useful building block, used in the synthesis of aroylquinazolines via aroylation with aryl aldehydes. 4,7-Dichloroquinazoline has been identified as a dengue virus entry inhibitor.
Synthesis
31374-18-2
2148-57-4
The general procedure for the synthesis of 4,7-dichloroquinazoline from 7-chloro-4(3H)-quinazolinone was as follows: 7-chloro-3H-quinazolin-4-one (170, 0.155 g, 0.85830 mmol) was dissolved in a screw cap vial containing 1 mL of phosphorus oxychloride (POCl3). After sealing the vial, the reaction was placed in an oil bath at 100 °C for 3 hours. Upon completion of the reaction, the resulting solution was concentrated under vacuum and distilled three times by azeotropic distillation with toluene to completely remove the residual phosphorous trichloride, resulting in the target compound 4,7-dichloroquinazoline (171, 0.162 g, 0.81391 mmol, 94.828% yield). The mass spectrometry analysis showed m/z 199.0 ([M+H]+).
References
[1] Patent: WO2013/142613, 2013, A1. Location in patent: Page/Page column 175
[2] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980, vol. 19, # 12, p. 1084 - 1087
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 545 - 548
[5] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
4,7-Dichloroquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,7-Dichloroquinazoline manufacturers
- Product
- 4,7-Dichloroquinazoline 2148-57-4
- Price
- US $3500.00/Kg
- Min. Order
- 1Kg
- Purity
- 99 %
- Supply Ability
- 500 Kg
- Release date
- 2024-11-12
- Product
- 4,7-Dichloroquinazoline 2148-57-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-10