ChemicalBook > CAS DataBase List > 1,2-BIS(TOSYLOXY)ETHANE

1,2-BIS(TOSYLOXY)ETHANE

Product Name: 1,2-BIS(TOSYLOXY)ETHANE
CAS No.: 6315-52-2
Chemical Name: 1,2-BIS(TOSYLOXY)ETHANE
Synonyms: Ethane-1,2-diyl bis(4-Methylbenzenesulfonate);ETHYLENE DITOSYLATE;ETHYLENE GLYCOL DITOSYLATE;AIDS124301;Tos-PEG1-Tos;TSO-PEG1-OTS;Di-O-tosylglycol;Plesafu Impurity 3;Bis(tosyloxy)ethane;Pulesafu impurity 37
CBNumber: CB9151509
Molecular Formula: C16H18O6S2
Formula Weight: 370.44
MOL File: 6315-52-2.mol

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1,2-BIS(TOSYLOXY)ETHANE Property

Melting point:: 124-127 °C(lit.)
Boiling point:: 544.3±38.0 °C(Predicted)
Density: 1.326
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
form: Solid
color: White to Off-White
Water Solubility: Slightly soluble in water.
BRN: 2399520
InChI: InChI=1S/C16H18O6S2/c1-13-3-7-15(8-4-13)23(17,18)21-11-12-22-24(19,20)16-9-5-14(2)6-10-16/h3-10H,11-12H2,1-2H3
InChIKey: LZIPBJBQQPZLOR-UHFFFAOYSA-N
SMILES: C(OS(C1=CC=C(C)C=C1)(=O)=O)COS(C1=CC=C(C)C=C1)(=O)=O
CAS DataBase Reference: 6315-52-2(CAS DataBase Reference)
EPA Substance Registry System: 1,2-Ethanediol, bis(4-methylbenzenesulfonate) (6315-52-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2905.31.0000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 296791
Product name: Ethylene di(p-toluenesulfonate)
Purity: 97%
Packaging: 5g
Price: $54.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 296791
Product name: Ethylene di(p-toluenesulfonate)
Purity: 97%
Packaging: 25g
Price: $170
Updated: 2025/07/31

TCI Chemical

Product number: E0438
Product name: 1,2-Bis(tosyloxy)ethane
Purity: >99.0%(HPLC)
Packaging: 25g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: E0438
Product name: 1,2-Bis(tosyloxy)ethane
Purity: >99.0%(HPLC)
Packaging: 100g
Price: $237
Updated: 2025/07/31

TRC

Product number: B419350
Product name: 1,2-Bis(tosyloxy)ethane
Packaging: 2.5g
Price: $70
Updated: 2021/12/16

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1,2-BIS(TOSYLOXY)ETHANE Chemical Properties,Usage,Production

Chemical Properties

Colourless solid

Uses

Ethylene di(p-toluenesulfonate) [Ethylene glycol ditosylate] has been used in the synthesis of, cyclohexyl-fused 1,4,7-triazacyclononane, 1,2-ethylenecalix[6]arene, 1,3- and 1,4-calix[6]crown-3, 1,3- and 1,4-calix[6]crown-4, 1,4-calix[6]benzocrown-4, 1,2- and 1,3-calix[6]crown-5.

Synthesis

107-21-1

98-59-9

6315-52-2

The general procedure for the synthesis of 1,2-bis(tolyloxy)ethane from ethylene glycol and p-toluenesulfonyl chloride was as follows: 19.8 g (0.3 mol) of ethylene glycol was dissolved in 150 mL of distilled pyridine, and the solution was subsequently cooled in an ice bath. Under mechanical stirring, p-toluenesulfonyl chloride (123 g, 0.65 mol) was slowly added and it was ensured that the reaction temperature was maintained below 20°C during the addition. When approximately 90 g of p-toluenesulfonyl chloride was added, stirring was difficult due to the increased viscosity of the mixture, at which point 200 mL of pyridine was added for dilution. Stirring of the reaction mixture was continued for 2 hours and 30 minutes. Upon completion of the reaction, an aqueous HCl solution consisting of 12 N HCl (170 mL) and ice (500 mL) was added to the mixture. The solid formed in the process was removed by filtration. The resulting solid was dissolved in 250 mL of refluxing methanol and subsequently filtered to remove the newly formed precipitate after cooling to room temperature. Finally, the obtained white solid was dried under vacuum to give the pure product 1,2-bis-toluoxyethane (92.4 g, 83% yield). The product was characterized as follows: 1H NMR (200 MHz, CDCl3) δ 7.71 (d, 2H), 7.31 (d, 2H), 4.16 (s, 2H), 2.43 (s, 3H).

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6678 - 6680
[2] Synthetic Communications, 1995, vol. 25, # 14, p. 2037 - 2042
[3] Macromolecular Bioscience, 2014, vol. 14, # 12, p. 1807 - 1815
[4] Tetrahedron Letters, 2001, vol. 42, # 50, p. 8781 - 8783
[5] Journal of the Chinese Chemical Society, 2004, vol. 51, # 5 B, p. 1201 - 1208

1,2-BIS(TOSYLOXY)ETHANE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,2-BIS(TOSYLOXY)ETHANE manufacturers

YiZheng HaiFan Chemical CO., LTD.

Product: Bis(tosyloxy)ethane 6315-52-2
Price: US $0.00/kg/ drum
Min. Order: 25kg/ drum
Purity: 99%
Supply Ability: 10 tons
Release date: 2025-12-04

Xian confluore Biological Technology Co., Ltd.

Product: Tos-PEG2-Tos 6315-52-2
Price: US $0.00/g
Min. Order: 500g
Purity: >98.00%
Supply Ability: 500g
Release date: 2024-03-27

Chemwill Asia Co.,Ltd.

Product: 1,2-Bis(tosyloxy)ethane 6315-52-2 1,2-Ethanediol ditosylate 6315-52-2
Price: US $12.50/KG
Min. Order: 1KG
Purity: 99.50% IN STOCK
Supply Ability: 550 MT per month
Release date: 2019-08-31

6315-52-2, 1,2-BIS(TOSYLOXY)ETHANERelated Search:

1,2-Bis(chloromethyl)benzene 4-Methylbenzyl chloride P-XYLENE 4-CHLOROMETHYLBENZALDEHYDE; >95%DISCONTINUED 10/25/01 1,4-Benzenedimethanol 1,3-Bis(chloromethyl)benzene 4-(CHLOROMETHYL)BENZYL ALCOHOL 99 ethylene bis[3,3-bis(3-tert-butyl-4-hydroxyphenyl)butyrate] 1,2-Ethanediol, dibenzenesulfonate Ethylidene diacetate 1,2-BIS(TOSYLOXY)ETHANE Ethylene glycol ETHYLENE-D4 GLYCOL (S)-(-)-1,2-PROPANEDIOL DI-P-TOSYLATE METHYL-4,6-O-BENZYLIDENE-2,3-DI-(O-TOSYL)-A-D-GLUCOPYRANOSIDE (2S,3S)-2,3-DI-O-TOSYLBUTANEDIOL METHYL 4,6-O-BENZYLIDENE-2,3-DI-O-(TOSYL)-ALPHA-D-GLUCOPYRANOSIDE CHEMPACIFIC 35909

1,2-Bis(4-methylbenzenesulfonyloxy)ethane

1,2-Bis(p-tolylsulfonyloxy)ethane

1,2-Di(tosyloxy)ethane

1,2-Ethanediol 1,2-bis(4-methylbenzenesulfonate):1,2-Ethanediol:1,2-bis(4-methylbenzenesulfonate)

1,2-Ethanediol ditosylate

1,2-Ethylene ditosylate

Di-O-tosylglycol

Ethylene 1,2-bis(tosylate)

Ethylene glycol ditoluenesulfonate

Ethylene glycol ditosylat

Ethylene ditosylate, Ethylene glycol ditosylate

Bis(4-methylbenzenesulfonic acid)1,2-ethanediyl ester

Ethylene glycol di-p-toluenesulfonate

Ethylene di(p-toluenesulfonate),Ethylene ditosylate, Ethylene glycol ditosylate

AIDS124301

1,2-ETHANEDIOLBIS(4-METHYLBENZENESULFONATE)

1,2-Di(p-tosyloxy)ethane

1,2-Bis(p-toluenesulfonyloxy)ethane Ethylene Glycol Bis(p-toluenesulfonate) Ethylene Glycol Ditosylate

Ethane-1,2-diyl bis(4-Methylbenzenesulfonate)

1,2-Ethanediol,1,2-bis(4-methylbenzenesulfonate)

1,2-BIS(TOSYLOXY)ETHANE

1,2-BIS(P-TOLUENESULFONYLOXY)ETHANE

Plesafu Impurity 3

ETHYLENE GLYCOL BIS-P-TOLUENESULFONATE

ETHYLENE DITOSYLATE

ETHYLENE GLYCOL DI-P-TOSYLATE

ETHYLENE GLYCOL DITOSYLATE

1,2-Bis(tosyloxy)ethane6315-52-2

Ethylene di(p-toluenesulfonate)

1,2-Bis(tosyloxy)ethane 6315-52-2 1,2-Ethanediol ditosylate

6315-52-2 1,2-Bis(tosyloxy)ethane

1,2-Bis(tosyloxy)ethane&gt

Plerixafor Impurity 47

Tos-PEG1-Tos

Pulesafu impurity 37

2-(4-methylphenyl)sulfonyloxyethyl 4-methylbenzenesulfonate

Ethylene di(<i>p</i>-toluenesulfonate)

Ethylene di(p-toluenesulfonate), 97%

Ethane-1,2-diyl bis(4-methylbenzenesulfonate) , 1,2-Bis(tosyloxy)ethane

TSO-PEG1-OTS

Bis(tosyloxy)ethane

6315-52-2

CH3C6H4SO3CH22

C16H18O6S2

Building Blocks

Sulfur Compounds

Tosylates

Organic Building Blocks