1,2-BIS(TOSYLOXY)ETHANE
- Product Name
- 1,2-BIS(TOSYLOXY)ETHANE
- CAS No.
- 6315-52-2
- Chemical Name
- 1,2-BIS(TOSYLOXY)ETHANE
- Synonyms
- Ethane-1,2-diyl bis(4-Methylbenzenesulfonate);ETHYLENE DITOSYLATE;ETHYLENE GLYCOL DITOSYLATE;AIDS124301;Tos-PEG1-Tos;TSO-PEG1-OTS;Di-O-tosylglycol;Plesafu Impurity 3;Bis(tosyloxy)ethane;Pulesafu impurity 37
- CBNumber
- CB9151509
- Molecular Formula
- C16H18O6S2
- Formula Weight
- 370.44
- MOL File
- 6315-52-2.mol
1,2-BIS(TOSYLOXY)ETHANE Property
- Melting point:
- 124-127 °C(lit.)
- Boiling point:
- 544.3±38.0 °C(Predicted)
- Density
- 1.326
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Slightly soluble in water.
- BRN
- 2399520
- InChI
- InChI=1S/C16H18O6S2/c1-13-3-7-15(8-4-13)23(17,18)21-11-12-22-24(19,20)16-9-5-14(2)6-10-16/h3-10H,11-12H2,1-2H3
- InChIKey
- LZIPBJBQQPZLOR-UHFFFAOYSA-N
- SMILES
- C(OS(C1=CC=C(C)C=C1)(=O)=O)COS(C1=CC=C(C)C=C1)(=O)=O
- CAS DataBase Reference
- 6315-52-2(CAS DataBase Reference)
- EPA Substance Registry System
- 1,2-Ethanediol, bis(4-methylbenzenesulfonate) (6315-52-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 296791
- Product name
- Ethylene di(p-toluenesulfonate)
- Purity
- 97%
- Packaging
- 5g
- Price
- $54.6
- Updated
- 2025/07/31
- Product number
- 296791
- Product name
- Ethylene di(p-toluenesulfonate)
- Purity
- 97%
- Packaging
- 25g
- Price
- $170
- Updated
- 2025/07/31
- Product number
- E0438
- Product name
- 1,2-Bis(tosyloxy)ethane
- Purity
- >99.0%(HPLC)
- Packaging
- 25g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- E0438
- Product name
- 1,2-Bis(tosyloxy)ethane
- Purity
- >99.0%(HPLC)
- Packaging
- 100g
- Price
- $237
- Updated
- 2025/07/31
- Product number
- B419350
- Product name
- 1,2-Bis(tosyloxy)ethane
- Packaging
- 2.5g
- Price
- $70
- Updated
- 2021/12/16
1,2-BIS(TOSYLOXY)ETHANE Chemical Properties,Usage,Production
Chemical Properties
Colourless solid
Uses
Ethylene di(p-toluenesulfonate) [Ethylene glycol ditosylate] has been used in the synthesis of, cyclohexyl-fused 1,4,7-triazacyclononane, 1,2-ethylenecalix[6]arene, 1,3- and 1,4-calix[6]crown-3, 1,3- and 1,4-calix[6]crown-4, 1,4-calix[6]benzocrown-4, 1,2- and 1,3-calix[6]crown-5.
Synthesis
107-21-1
98-59-9
6315-52-2
The general procedure for the synthesis of 1,2-bis(tolyloxy)ethane from ethylene glycol and p-toluenesulfonyl chloride was as follows: 19.8 g (0.3 mol) of ethylene glycol was dissolved in 150 mL of distilled pyridine, and the solution was subsequently cooled in an ice bath. Under mechanical stirring, p-toluenesulfonyl chloride (123 g, 0.65 mol) was slowly added and it was ensured that the reaction temperature was maintained below 20°C during the addition. When approximately 90 g of p-toluenesulfonyl chloride was added, stirring was difficult due to the increased viscosity of the mixture, at which point 200 mL of pyridine was added for dilution. Stirring of the reaction mixture was continued for 2 hours and 30 minutes. Upon completion of the reaction, an aqueous HCl solution consisting of 12 N HCl (170 mL) and ice (500 mL) was added to the mixture. The solid formed in the process was removed by filtration. The resulting solid was dissolved in 250 mL of refluxing methanol and subsequently filtered to remove the newly formed precipitate after cooling to room temperature. Finally, the obtained white solid was dried under vacuum to give the pure product 1,2-bis-toluoxyethane (92.4 g, 83% yield). The product was characterized as follows: 1H NMR (200 MHz, CDCl3) δ 7.71 (d, 2H), 7.31 (d, 2H), 4.16 (s, 2H), 2.43 (s, 3H).
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6678 - 6680
[2] Synthetic Communications, 1995, vol. 25, # 14, p. 2037 - 2042
[3] Macromolecular Bioscience, 2014, vol. 14, # 12, p. 1807 - 1815
[4] Tetrahedron Letters, 2001, vol. 42, # 50, p. 8781 - 8783
[5] Journal of the Chinese Chemical Society, 2004, vol. 51, # 5 B, p. 1201 - 1208
1,2-BIS(TOSYLOXY)ETHANE Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-BIS(TOSYLOXY)ETHANE Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 1,2-BIS(TOSYLOXY)ETHANE manufacturers
- Product
- Bis(tosyloxy)ethane 6315-52-2
- Price
- US $0.00/kg/ drum
- Min. Order
- 25kg/ drum
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2025-12-04
- Product
- Tos-PEG2-Tos 6315-52-2
- Price
- US $0.00/g
- Min. Order
- 500g
- Purity
- >98.00%
- Supply Ability
- 500g
- Release date
- 2024-03-27
- Product
- 1,2-Bis(tosyloxy)ethane 6315-52-2 1,2-Ethanediol ditosylate 6315-52-2
- Price
- US $12.50/KG
- Min. Order
- 1KG
- Purity
- 99.50% IN STOCK
- Supply Ability
- 550 MT per month
- Release date
- 2019-08-31