palovarotene

Product Name: palovarotene
CAS No.: 410528-02-8
Chemical Name: palovarotene
Synonyms: R 667;Ro 3300074;palovarotene;Unii-28K6I5m16g;R 667;RO 3300074;Ro 3300074|||R 667;Palovarotene(R 667);R667;R 667;R667;RO-3300074;RO 3300074;RO3300074;4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid;(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
CBNumber: CB91518527
Molecular Formula: C27H30N2O2
Formula Weight: 414.54
MOL File: 410528-02-8.mol

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palovarotene Property

Melting point:: 249-252°C
Boiling point:: 592.3±50.0 °C(Predicted)
Density: 1.11
storage temp.: Refrigerator
solubility: DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
pka: 4.26±0.10(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28460
Product name: Palovarotene
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 28460
Product name: Palovarotene
Packaging: 25mg
Price: $336
Updated: 2024/03/01

Cayman Chemical

Product number: 28460
Product name: Palovarotene
Packaging: 10mg
Price: $152
Updated: 2024/03/01

TRC

Product number: P165900
Product name: Palovarotene
Packaging: 100mg
Price: $1455
Updated: 2021/12/16

ChemScene

Product number: CS-2031
Product name: Palovarotene
Purity: 99.49%
Packaging: 100mg
Price: $1600
Updated: 2021/12/16

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palovarotene Chemical Properties,Usage,Production

Description

Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1^R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1^R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.

Uses

Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.

Definition

ChEBI: Palovarotene is a stilbenoid.

palovarotene Preparation Products And Raw materials

Raw materials

Preparation Products

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palovarotene Suppliers

China 95 France 1 India 1 United States 12 Global 109

MedChemexpress LLC

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Musechem

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TargetMol Chemicals Inc.

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MedChemExpress

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View Lastest Price from palovarotene manufacturers

Career Henan Chemical Co

Product: Palovarotene 410528-02-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

410528-02-8, palovaroteneRelated Search:

ANTI-ESTROGEN RECEPTOR Ethylamine (-)-Varitriol palovarotene 4-ISOPROPYL-1-METHYL-2-PROPENYLBENZENE 1-ISOPROPYL-4-(2-PHENYLVINYL)BENZENE (5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTH-2-YL)METHYLAMINE

palovarotene

4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid

Unii-28K6I5m16g

R 667

Ro 3300074

(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

Palovarotene(R 667)

R 667;RO 3300074

4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid

R667;R 667;R667;RO-3300074;RO 3300074;RO3300074

Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]-

Ro 3300074|||R 667

410528-02-8