6-chloro-5-methyl-2H-pyridazin-3-one
- Product Name
- 6-chloro-5-methyl-2H-pyridazin-3-one
- CAS No.
- 1703-07-7
- Chemical Name
- 6-chloro-5-methyl-2H-pyridazin-3-one
- Synonyms
- 137015;6-chloro-5-methylpyridazine-3-one;3-chloro-4-methyl-1H-pyridazin-6-one;6-Chloro-5-Methylpyridazin-3(2H)-one;6-chloro-5-methyl-2H-pyridazin-3-one;6-Chloro-3-hydroxy-5-methylpyridazine;3(2H)-Pyridazinone, 6-chloro-5-Methyl-;6-Chloro-3-hydroxy-5-methylpyridazine 97%;6-Chloro-5-methylpyridazin-3-ol, 6-Chloro-3-hydroxy-5-methyl-1,2-diazine
- CBNumber
- CB91519812
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 1703-07-7.mol
6-chloro-5-methyl-2H-pyridazin-3-one Property
- Melting point:
- 225 °C(Solv: water (7732-18-5))
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.83±0.60(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C5H5ClN2O/c1-3-2-4(9)7-8-5(3)6/h2H,1H3,(H,7,9)
- InChIKey
- UGDOVAWXAHZLEV-UHFFFAOYSA-N
- SMILES
- C1(=O)NN=C(Cl)C(C)=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C991338
- Product name
- 6-Chloro-5-methylpyridazin-3(2H)-one
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- OR304306
- Product name
- 6-Chloro-3-hydroxy-5-methylpyridazine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 4H56-5-LN
- Product name
- 6-Chloro-3-hydroxy-5-methylpyridazine
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FC141622
- Product name
- 6-Chloro-5-methylpyridazin-3(2H)-one
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC141622
- Product name
- 6-Chloro-5-methylpyridazin-3(2H)-one
- Packaging
- 250mg
- Price
- $300
- Updated
- 2021/12/16
6-chloro-5-methyl-2H-pyridazin-3-one Chemical Properties,Usage,Production
Synthesis
19064-64-3
1834-27-1
1703-07-7
3,6-Dichloro-4-methylpyridazine (30.6 g, 190 mmol) was suspended in glacial acetic acid (800 mL) at room temperature and subsequently heated in an oil bath at 110-115°C for 3 hours (the mixture became homogeneous after 1 hour of reaction). Upon completion of the reaction, the mixture was cooled to room temperature and the acetic acid was removed by distillation under reduced pressure. The solid residue obtained was slowly added to saturated sodium bicarbonate solution (200 mL) to obtain a light yellow non-homogeneous mixture, which was then adjusted to pH 6 by slowly adding solid sodium bicarbonate with vigorous stirring.The mixture was extracted with dichloromethane (2 x 250 mL), and the combined organic phases were washed with saturated aqueous sodium bicarbonate, then washed with sodium chloride (60 mL) and finally dried and concentrated with anhydrous magnesium sulfate. Finally, it was dried and concentrated to obtain the crude product (20.9 g). The crude product (20.9 g) was purified by column chromatography (elution gradient: 1% methanol/dichloromethane to 5% methanol/dichloromethane), and 6-chloro-4-methyl-2H-pyridazin-3-one (13.4 g, 92.7 mmol, 49% yield) [Rf 0.21 (2.5% methanol/dichloromethane)] and 6-chloro-5-methyl-2H-pyridazin-3-one (5.00 g, 34.6 mmol, 18% yield) [Rf 0.11 (2.5% methanol/dichloromethane)], both colorless solids.NMR data for 6-chloro-4-methyl-2H-pyridazin-3-one: 1H NMR (200 MHz, CDCl3-CD3OD): δ 2.12 (3H, s), 3.55 (1H, br s), 7.05 (1H, s); 13C NMR (50 MHz, CDCl3): δ 16.1 (CH3), 131.7 (CH-5), 139.0 (C-6), 143.0 (C-4), 161.9 (C-3).Physical and spectroscopic data of 6-chloro-5-methyl-2H-pyridazin-3-one: melting point 172-173°C (recrystallized from dichloromethane/light petroleum ether) ; 1H NMR (200 MHz, CDCl3): δ 2.20 (3H, d, J = 1.3 Hz), 7.13 (1H, q, J = 1.3 Hz); 13C NMR (50 MHz, CDCl3): δ 16.3 (CH3), 131.9 (CH-5), 139.2 (C-4), 143.2 (C-6), 161.9 (C-3). Low resolution mass spectrum (EI): m/z 144 ([M+]). Calculated elemental analysis (C5H5ClN2O): C, 41.54; H, 3.49; N, 19.38. Measured values: C, 41.55; H, 3.51; N, 19.22.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Patent: US2012/108578, 2012, A1. Location in patent: Page/Page column 26
[3] Acta Chemica Scandinavica (1947-1973), 1961, vol. 15, p. 1660,1665
[4] Pharmaceutical Bulletin, 1957, vol. 6, p. 587,589
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
6-chloro-5-methyl-2H-pyridazin-3-one Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-chloro-5-methyl-2H-pyridazin-3-one manufacturers
- Product
- 6-chloro-5-methylpyridazin-3(2H)-one 1703-07-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-09
- Product
- 6-chloro-5-methyl-2H-pyridazin-3-one 1703-07-7
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.9%
- Supply Ability
- 100g,1kg,5kg
- Release date
- 2019-09-10