ChemicalBook > CAS DataBase List > 6-chloro-5-methyl-2H-pyridazin-3-one

6-chloro-5-methyl-2H-pyridazin-3-one

Product Name: 6-chloro-5-methyl-2H-pyridazin-3-one
CAS No.: 1703-07-7
Chemical Name: 6-chloro-5-methyl-2H-pyridazin-3-one
Synonyms: 137015;6-chloro-5-methylpyridazine-3-one;3-chloro-4-methyl-1H-pyridazin-6-one;6-Chloro-5-Methylpyridazin-3(2H)-one;6-chloro-5-methyl-2H-pyridazin-3-one;6-Chloro-3-hydroxy-5-methylpyridazine;3(2H)-Pyridazinone, 6-chloro-5-Methyl-;6-Chloro-3-hydroxy-5-methylpyridazine 97%;6-Chloro-5-methylpyridazin-3-ol, 6-Chloro-3-hydroxy-5-methyl-1,2-diazine
CBNumber: CB91519812
Molecular Formula: C5H5ClN2O
Formula Weight: 144.56
MOL File: 1703-07-7.mol

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6-chloro-5-methyl-2H-pyridazin-3-one Property

Melting point:: 225 °C(Solv: water (7732-18-5))
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 9.83±0.60(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C5H5ClN2O/c1-3-2-4(9)7-8-5(3)6/h2H,1H3,(H,7,9)
InChIKey: UGDOVAWXAHZLEV-UHFFFAOYSA-N
SMILES: C1(=O)NN=C(Cl)C(C)=C1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C991338
Product name: 6-Chloro-5-methylpyridazin-3(2H)-one
Packaging: 500mg
Price: $310
Updated: 2021/12/16

Apolloscientific

Product number: OR304306
Product name: 6-Chloro-3-hydroxy-5-methylpyridazine
Purity: 97%
Packaging: 250mg
Price: $127
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-5-LN
Product name: 6-Chloro-3-hydroxy-5-methylpyridazine
Packaging: 250mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141622
Product name: 6-Chloro-5-methylpyridazin-3(2H)-one
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141622
Product name: 6-Chloro-5-methylpyridazin-3(2H)-one
Packaging: 250mg
Price: $300
Updated: 2021/12/16

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6-chloro-5-methyl-2H-pyridazin-3-one Chemical Properties,Usage,Production

Synthesis

19064-64-3

1834-27-1

1703-07-7

3,6-Dichloro-4-methylpyridazine (30.6 g, 190 mmol) was suspended in glacial acetic acid (800 mL) at room temperature and subsequently heated in an oil bath at 110-115°C for 3 hours (the mixture became homogeneous after 1 hour of reaction). Upon completion of the reaction, the mixture was cooled to room temperature and the acetic acid was removed by distillation under reduced pressure. The solid residue obtained was slowly added to saturated sodium bicarbonate solution (200 mL) to obtain a light yellow non-homogeneous mixture, which was then adjusted to pH 6 by slowly adding solid sodium bicarbonate with vigorous stirring.The mixture was extracted with dichloromethane (2 x 250 mL), and the combined organic phases were washed with saturated aqueous sodium bicarbonate, then washed with sodium chloride (60 mL) and finally dried and concentrated with anhydrous magnesium sulfate. Finally, it was dried and concentrated to obtain the crude product (20.9 g). The crude product (20.9 g) was purified by column chromatography (elution gradient: 1% methanol/dichloromethane to 5% methanol/dichloromethane), and 6-chloro-4-methyl-2H-pyridazin-3-one (13.4 g, 92.7 mmol, 49% yield) [Rf 0.21 (2.5% methanol/dichloromethane)] and 6-chloro-5-methyl-2H-pyridazin-3-one (5.00 g, 34.6 mmol, 18% yield) [Rf 0.11 (2.5% methanol/dichloromethane)], both colorless solids.NMR data for 6-chloro-4-methyl-2H-pyridazin-3-one: 1H NMR (200 MHz, CDCl3-CD3OD): δ 2.12 (3H, s), 3.55 (1H, br s), 7.05 (1H, s); 13C NMR (50 MHz, CDCl3): δ 16.1 (CH3), 131.7 (CH-5), 139.0 (C-6), 143.0 (C-4), 161.9 (C-3).Physical and spectroscopic data of 6-chloro-5-methyl-2H-pyridazin-3-one: melting point 172-173°C (recrystallized from dichloromethane/light petroleum ether) ; 1H NMR (200 MHz, CDCl3): δ 2.20 (3H, d, J = 1.3 Hz), 7.13 (1H, q, J = 1.3 Hz); 13C NMR (50 MHz, CDCl3): δ 16.3 (CH3), 131.9 (CH-5), 139.2 (C-4), 143.2 (C-6), 161.9 (C-3). Low resolution mass spectrum (EI): m/z 144 ([M+]). Calculated elemental analysis (C5H5ClN2O): C, 41.54; H, 3.49; N, 19.38. Measured values: C, 41.55; H, 3.51; N, 19.22.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Patent: US2012/108578, 2012, A1. Location in patent: Page/Page column 26
[3] Acta Chemica Scandinavica (1947-1973), 1961, vol. 15, p. 1660,1665
[4] Pharmaceutical Bulletin, 1957, vol. 6, p. 587,589
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233

6-chloro-5-methyl-2H-pyridazin-3-one Preparation Products And Raw materials

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View Lastest Price from 6-chloro-5-methyl-2H-pyridazin-3-one manufacturers

Shanghai Rlavie Technology Co ltd

Product: 6-chloro-5-methylpyridazin-3(2H)-one 1703-07-7
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-09

Career Henan Chemical Co

Product: 6-chloro-5-methyl-2H-pyridazin-3-one 1703-07-7
Price: US $5.00/KG
Min. Order: 1KG
Purity: 85.0-99.9%
Supply Ability: 100g,1kg,5kg
Release date: 2019-09-10

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