(R)-4-Chloro-3-hydroxybutyronitrile

Product Name: (R)-4-Chloro-3-hydroxybutyronitrile
CAS No.: 84367-31-7
Chemical Name: (R)-4-Chloro-3-hydroxybutyronitrile
Synonyms: (R)-4-Chloro-3-hydro;L-carnitine Impurity 6;Levocarnitine Impurity 47;(R)-1-CHLOROPENT-4-YN-2-OL;(R)-4-Cloro-3-Hydroxybutyronitrile;(3S)-4-Chlor-3-hydroxybutanonitril;(R)-4-CHLORO-3-HYDROXYBUTYRONITRILE;(R)-4-Chloro-3-hydroxybutanenitrile;(R/S)4-Chloro-3-Hydroxybutyronitrile;(3R)-4-Chloro-3-hydroxybutanenitrile
CBNumber: CB9157309
Molecular Formula: C4H6ClNO
Formula Weight: 119.55
MOL File: 84367-31-7.mol

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(R)-4-Chloro-3-hydroxybutyronitrile Property

alpha: 11 º (neat)
Boiling point:: 110 °C1 mm Hg(lit.)
Density: 1.250 g/mL at 20 °C(lit.)
refractive index: n20/D 1.474(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
pka: 12.67±0.20(Predicted)
color: Colorless to Light yellow
optical activity: [α]25/D +11.0°, neat
BRN: 1700586
InChI: InChI=1S/C4H6ClNO/c5-3-4(7)1-2-6/h4,7H,1,3H2/t4-/m1/s1
InChIKey: LHBPNZDUNCZWFL-SCSAIBSYSA-N
SMILES: C(#N)C[C@@H](O)CCl
CAS DataBase Reference: 84367-31-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HS Code: 29269090
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 456152
Product name: (R)-(+)-4-Chloro-3-hydroxybutyronitrile
Purity: 97%
Packaging: 1g
Price: $119
Updated: 2022/05/15

TCI Chemical

Product number: C2763
Product name: (R)-(+)-4-Chloro-3-hydroxybutyronitrile
Purity: >96.0%(GC)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: C2763
Product name: (R)-(+)-4-Chloro-3-hydroxybutyronitrile
Purity: >96.0%(GC)
Packaging: 5g
Price: $126
Updated: 2025/07/31

TRC

Product number: C366675
Product name: (R)-(+)-4-Chloro-3-hydroxybutyronitrile
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152698
Product name: (R)-4-Chloro-3-hydroxybutyronitrile
Packaging: 2g
Price: $50
Updated: 2021/12/16

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(R)-4-Chloro-3-hydroxybutyronitrile Chemical Properties,Usage,Production

Chemical Properties

Colorless to pale yellow liquid

Uses

(-)-Carnitine and (-)-γ-amino-β-hydroxybutyric acid have been prepared using this synthon.

Uses

(R)-(+)-4-Chloro-3-hydroxybutyronitrile is a chiral reagent used in asymmetric catalysis in organic synthesis.

Synthesis

(1) 19.19g (0.174mol) (R)-(-)-chloroglycerol, 50ml dichloromethane into a 250ml three-necked flask, under the condition of ice bath, 22.74g (0.191oml) dichlorosulfoxide was added slowly dropwise. React for 1h, add 40ml of water, the organic layer was washed twice with saturated saline, the aqueous layer was washed twice with ethyl acetate, the organic layers were combined and dried with anhydrous sodium sulfate. Filtration, filtrate concentrated under reduced pressure, obtained 27.23g colorless liquid. That is, cyclic sulfinic acid ester intermediate, without purification, directly used in the next step of the reaction, yield 100%.

(2) cast 10g (0.064mol) cyclic sulfinic acid ester, 30ml methanol to 100ml three-necked bottle, room temperature conditions, add 5.21g (0.08mol) KCN, stirring for 10min, and then raised to 50 ??, stirring vigorously for 12h. Concentrate under reduced pressure, add 15 ml of ethyl acetate and slowly add 20% H2SO4 solution dropwise. After stirring for 5h, add dilute NaCO3 solution washed twice, water washed twice, saturated brine washed once, the aqueous layer was washed with ethyl acetate, the organic layer was combined, and anhydrous sodium sulfate was added to dry. Decompression distillation was used to collect the 89-90??C/<1 mmHg fraction, yielding 6.51 g of colorless liquid, i.e., chlorobutyronitrile intermediate, with a yield of 85%.

(R)-4-Chloro-3-hydroxybutyronitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-Chloro-3-hydroxybutyronitrile Suppliers

Americas 1 Canada 2 China 193 Europe 2 France 2 Germany 3 India 6 Japan 4 Slovakia 1 South Korea 3 Switzerland 1 The Netherlands 1 United Kingdom 10 United States 34 Global 263

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View Lastest Price from (R)-4-Chloro-3-hydroxybutyronitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: (R)-4-Chloro-3-hydroxybutyronitrile 84367-31-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-4-Chloro-3-hydroxybutyronitrile 84367-31-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: (R)-4-Chloro-3-hydroxybutyronitrile 84367-31-7
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-22

84367-31-7, (R)-4-Chloro-3-hydroxybutyronitrileRelated Search:

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(R)-(+)-4-CHLORO-3-HYDROXYBUTYRONITRILE

(R)-4-CHLORO-3-HYDROXYBUTYRONITRILE

(R)-4-Cloro-3-Hydroxybutyronitrile

(R)-1-CHLOROPENT-4-YN-2-OL

(R)-4-Chloro-3-hydro

(R/S)4-Chloro-3-Hydroxybutyronitrile

(R)-4-Chloro-3-hydroxybutanenitrile

Butanenitrile,4-chloro-3-hydroxy-, (3R)-

(R)-(+)-4-Chloro-3-hydroxybutyronitrile &gt

(R)-4-Chloro-3-Hydroxylbutyronitrile

(3R)-4-Chloro-3-hydroxybutanenitrile

Levocarnitine Impurity 47

(3S)-4-Chlor-3-hydroxybutanonitril

L-carnitine Impurity 6

(<i>R</i>)-(+)-4-Chloro-3-hydroxybutyronitrile

84367-31-7

ClCH2CHOHCH2CN

Asymmetric Synthesis

Chiral Building Blocks

Organic Building Blocks

Cyanides/Nitriles

Chiral Building Blocks

Cyanides/Nitriles

Organic Building Blocks