ChemicalBook > CAS DataBase List > (R)-4-Chloro-3-hydroxybutyronitrile

(R)-4-Chloro-3-hydroxybutyronitrile

Product Name
(R)-4-Chloro-3-hydroxybutyronitrile
CAS No.
84367-31-7
Chemical Name
(R)-4-Chloro-3-hydroxybutyronitrile
Synonyms
(R)-4-Chloro-3-hydro;L-carnitine Impurity 6;Levocarnitine Impurity 47;(R)-1-CHLOROPENT-4-YN-2-OL;(R)-4-Cloro-3-Hydroxybutyronitrile;(3S)-4-Chlor-3-hydroxybutanonitril;(R)-4-CHLORO-3-HYDROXYBUTYRONITRILE;(R)-4-Chloro-3-hydroxybutanenitrile;(R/S)4-Chloro-3-Hydroxybutyronitrile;(3R)-4-Chloro-3-hydroxybutanenitrile
CBNumber
CB9157309
Molecular Formula
C4H6ClNO
Formula Weight
119.55
MOL File
84367-31-7.mol
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(R)-4-Chloro-3-hydroxybutyronitrile Property

alpha 
11 º (neat)
Boiling point:
110 °C1 mm Hg(lit.)
Density 
1.250 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.474(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
clear liquid
pka
12.67±0.20(Predicted)
color 
Colorless to Light yellow
optical activity
[α]25/D +11.0°, neat
BRN 
1700586
InChI
InChI=1S/C4H6ClNO/c5-3-4(7)1-2-6/h4,7H,1,3H2/t4-/m1/s1
InChIKey
LHBPNZDUNCZWFL-SCSAIBSYSA-N
SMILES
C(#N)C[C@@H](O)CCl
CAS DataBase Reference
84367-31-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-21
HS Code 
29269090
Storage Class
10 - Combustible liquids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
456152
Product name
(R)-(+)-4-Chloro-3-hydroxybutyronitrile
Purity
97%
Packaging
1g
Price
$119
Updated
2022/05/15
TCI Chemical
Product number
C2763
Product name
(R)-(+)-4-Chloro-3-hydroxybutyronitrile
Purity
>96.0%(GC)
Packaging
1g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
C2763
Product name
(R)-(+)-4-Chloro-3-hydroxybutyronitrile
Purity
>96.0%(GC)
Packaging
5g
Price
$126
Updated
2025/07/31
TRC
Product number
C366675
Product name
(R)-(+)-4-Chloro-3-hydroxybutyronitrile
Packaging
2.5g
Price
$130
Updated
2021/12/16
AK Scientific
Product number
K505
Product name
(R)-(+)-4-Chloro-3-hydroxybutyronitrile
Packaging
500g
Price
$1227
Updated
2021/12/16
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(R)-4-Chloro-3-hydroxybutyronitrile Chemical Properties,Usage,Production

Chemical Properties

Colorless to pale yellow liquid

Uses

(-)-Carnitine and (-)-γ-amino-β-hydroxybutyric acid have been prepared using this synthon.

Uses

(R)-(+)-4-Chloro-3-hydroxybutyronitrile is a chiral reagent used in asymmetric catalysis in organic synthesis.

Synthesis

(1) 19.19g (0.174mol) (R)-(-)-chloroglycerol, 50ml dichloromethane into a 250ml three-necked flask, under the condition of ice bath, 22.74g (0.191oml) dichlorosulfoxide was added slowly dropwise. React for 1h, add 40ml of water, the organic layer was washed twice with saturated saline, the aqueous layer was washed twice with ethyl acetate, the organic layers were combined and dried with anhydrous sodium sulfate. Filtration, filtrate concentrated under reduced pressure, obtained 27.23g colorless liquid. That is, cyclic sulfinic acid ester intermediate, without purification, directly used in the next step of the reaction, yield 100%.

(2) cast 10g (0.064mol) cyclic sulfinic acid ester, 30ml methanol to 100ml three-necked bottle, room temperature conditions, add 5.21g (0.08mol) KCN, stirring for 10min, and then raised to 50 ??, stirring vigorously for 12h. Concentrate under reduced pressure, add 15 ml of ethyl acetate and slowly add 20% H2SO4 solution dropwise. After stirring for 5h, add dilute NaCO3 solution washed twice, water washed twice, saturated brine washed once, the aqueous layer was washed with ethyl acetate, the organic layer was combined, and anhydrous sodium sulfate was added to dry. Decompression distillation was used to collect the 89-90??C/<1 mmHg fraction, yielding 6.51 g of colorless liquid, i.e., chlorobutyronitrile intermediate, with a yield of 85%.

(R)-4-Chloro-3-hydroxybutyronitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-Chloro-3-hydroxybutyronitrile Suppliers

Americas 1 Canada 2 China 193 Europe 2 France 2 Germany 3 India 6 Japan 4 Slovakia 1 South Korea 3 Switzerland 1 The Netherlands 1 United Kingdom 10 United States 34 Global 263
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
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1791901229@qq.com
Country
China
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Shanghai Xuentian Technology Co.,Ltd.
Tel
18661722072
Email
mk@xuentian.cn
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China
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Tianjin Nuohan Chemical Co., Ltd.
Tel
16622132757 15822233263
Email
zhuxuchen2016@yeah.net
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Fax
021-67121385
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Sales-CN@TCIchemicals.com
Country
China
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24529
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Ark Pharm, Inc.
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847-367-3680
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847-367-3681
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sales@arkpharminc.com
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United States
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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China
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
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China
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View Lastest Price from (R)-4-Chloro-3-hydroxybutyronitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(R)-4-Chloro-3-hydroxybutyronitrile 84367-31-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-09
Hebei Chuanghai Biotechnology Co., Ltd
Product
(R)-4-Chloro-3-hydroxybutyronitrile 84367-31-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
(R)-4-Chloro-3-hydroxybutyronitrile 84367-31-7
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-22

84367-31-7, (R)-4-Chloro-3-hydroxybutyronitrileRelated Search:

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  • (R)-4-CHLORO-3-HYDROXYBUTYRONITRILE
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  • (R)-1-CHLOROPENT-4-YN-2-OL
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  • (R/S)4-Chloro-3-Hydroxybutyronitrile
  • (R)-4-Chloro-3-hydroxybutanenitrile
  • Butanenitrile,4-chloro-3-hydroxy-, (3R)-
  • (R)-(+)-4-Chloro-3-hydroxybutyronitrile &gt
  • (R)-4-Chloro-3-Hydroxylbutyronitrile
  • (3R)-4-Chloro-3-hydroxybutanenitrile
  • Levocarnitine Impurity 47
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  • L-carnitine Impurity 6
  • (<i>R</i>)-(+)-4-Chloro-3-hydroxybutyronitrile
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