[NPHE1]NOCICEPTIN(1-13)NH2
- Product Name
- [NPHE1]NOCICEPTIN(1-13)NH2
- CAS No.
- 267234-08-2
- Chemical Name
- [NPHE1]NOCICEPTIN(1-13)NH2
- Synonyms
- Bzl-GGGFTGARKSARK-NH2;[NPHE1]NOCICEPTIN(1-13)NH2;[N-PHE1]-NOCICEPTIN FRAGMENT 1-13 AMIDE;N-(BZL)GLY-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;N-（BN）Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg--Lys-Ser-Ala-Arg--Lys-NH2;N-(Bzl)Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2 (N-(Bzl)GlyN-Benzylglycine);L-Lysinamide, N-(phenylmethyl)glycylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-
- CBNumber
- CB9159323
- Molecular Formula
- C61H100N22O15
- Formula Weight
- 1381.59
- MOL File
- 267234-08-2.mol
[NPHE1]NOCICEPTIN(1-13)NH2 Property
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 1 mg/ml in 10% acetonitrile
- form
- lyophilized powder
- pka
- 12.91±0.46(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B5089
- Product name
- [Nphe1]Nociceptin(1-13)NH2
- Packaging
- 1mg
- Price
- $518
- Updated
- 2021/12/16
- Product number
- INB0000830
- Product name
- [N-PHE1]-NOCICEPTIN FRAGMENT-1-13 AMIDE
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $684.92
- Updated
- 2021/12/16
- Product number
- INB0000830
- Product name
- [N-PHE1]-NOCICEPTIN FRAGMENT-1-13 AMIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $846.5
- Updated
- 2021/12/16
- Product number
- INB0000830
- Product name
- [N-PHE1]-NOCICEPTIN FRAGMENT-1-13 AMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $957.59
- Updated
- 2021/12/16
- Product number
- INB0000830
- Product name
- [N-PHE1]-NOCICEPTIN FRAGMENT-1-13 AMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $1829.52
- Updated
- 2021/12/16
[NPHE1]NOCICEPTIN(1-13)NH2 Chemical Properties,Usage,Production
Uses
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].
References
[1] Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor DOI:10.1016/s0304-3940(99)00915-5
[2] G Calo', et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol.?2000 Mar;129(6):1183-93. DOI:10.1038/sj.bjp.0703169
[NPHE1]NOCICEPTIN(1-13)NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
[NPHE1]NOCICEPTIN(1-13)NH2 Suppliers
- Tel
- --
- Fax
- --
- info-tech@nacalai.co.jp
- Country
- Japan
- ProdList
- 6046
- Advantage
- 75