Methyl 4-chlorocarbonylbenzoate
- Product Name
- Methyl 4-chlorocarbonylbenzoate
- CAS No.
- 7377-26-6
- Chemical Name
- Methyl 4-chlorocarbonylbenzoate
- Synonyms
- CL-MMT;SKL743;TIMTEC-BB SBB005801;METHYL 4-CHLOROFORMYLBENZOATE;4-CARBOMETHOXYBENZOYL CHLORIDE;P-carbomethoxybenzoyl chloride;METHYL 4-CHLOROCARBONYLBENZOATE;Methy 4-chlorocarbonyl benzoate;Methyl terephthaloyl chloride;Methyl p-(Chlorocarbonyl)benzoate
- CBNumber
- CB9162433
- Molecular Formula
- C9H7ClO3
- Formula Weight
- 198.6
- MOL File
- 7377-26-6.mol
Methyl 4-chlorocarbonylbenzoate Property
- Melting point:
- 50-59 °C
- Boiling point:
- 140 °C / 15mmHg
- Density
- 1.3219 (rough estimate)
- refractive index
- 1.5230 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- HYDROLYSIS
- form
- Crystalline Powder
- color
- Off-white to light yellow
- Water Solubility
- HYDROLYSIS
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C9H7ClO3/c1-13-9(12)7-4-2-6(3-5-7)8(10)11/h2-5H,1H3
- InChIKey
- CVXXHXPNTZBZEL-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(C(Cl)=O)C=C1
- CAS DataBase Reference
- 7377-26-6(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-22
- Safety Statements
- 24/25-45-36/37/39-26
- RIDADR
- 3261
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 29173990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 671673
- Product name
- Methyl 4-(chlorocarbonyl)benzoate
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $81.5
- Updated
- 2025/07/31
- Product number
- 671673
- Product name
- Methyl 4-(chlorocarbonyl)benzoate
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $204
- Updated
- 2025/07/31
- Product number
- T0283
- Product name
- Methyl 4-(Chloroformyl)benzoate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- T0283
- Product name
- Methyl 4-(Chloroformyl)benzoate
- Purity
- >95.0%(GC)
- Packaging
- 500g
- Price
- $1001
- Updated
- 2025/07/31
- Product number
- C366050
- Product name
- 4-(Chlorocarbonyl)benzoicAcidMethylEster
- Packaging
- 10g
- Price
- $180
- Updated
- 2021/12/16
Methyl 4-chlorocarbonylbenzoate Chemical Properties,Usage,Production
Chemical Properties
slight yellow to white solid
Uses
4-(Chlorocarbonyl)benzoic Acid Methyl Ester, is a building block, that can be used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of benzophenone residues and also for the synthesis of novel novel bulky hydrophobic retinoids.
Synthesis
120-61-6
7377-26-6
This embodiment describes the synthesis of methyl 4-chlorocarbonylbenzoate. In a 4L reactor equipped with a mechanical stirrer, reflux condenser, charging funnel, thermometer, water bath and hot plate, 438 g of dimethyl terephthalate (DMT) and 2700 mL of toluene were added. The reactor was heated to about 65°C to completely dissolve the DMT. After dissolution was complete, potassium hydroxide solution (144.54 g dissolved in 700 mL of methanol) was added slowly and dropwise over 45 minutes. The reaction mixture was stirred at 65 °C for 3 h, followed by cooling to room temperature and standing overnight. The solid product was collected by filtration and washed with 3750 mL of toluene at 80 °C. After filtration again, the product was dried in an oven at 110 °C to give 465.9 g (95.3% yield). In another 2L three-necked round-bottomed flask equipped with a mechanical stirrer, a dosing funnel, a water bath, a thermometer, nitrogen protection and a hot plate, 130.31 g of the product prepared in the previous step and 1000 mL of toluene were added. Subsequently, 48 mL of thionyl chloride was slowly added dropwise. After the dropwise addition was completed, the mixture was heated to 67°C and maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and stirred overnight. The reaction mixture was filtered to collect the filtrate and the excess solvent was removed by distillation under reduced pressure to give 86.52 g of the target product (73% yield).
References
[1] Patent: WO2015/42561, 2015, A1. Location in patent: Paragraph 0115; 0116; 0117
[2] Patent: WO2015/42563, 2015, A1. Location in patent: Paragraph 0115; 0116; 0117
[3] Canadian Journal of Chemistry, 1974, vol. 52, p. 66 - 79
[4] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2763 - 2770
[5] Journal of the American Chemical Society, 1957, vol. 79, p. 96
Methyl 4-chlorocarbonylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-chlorocarbonylbenzoate manufacturers
- Product
- Methyl 4-chlorocarbonylbenzoate 7377-26-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-09-05
- Product
- Methyl 4-chlorocarbonylbenzoate 7377-26-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-26
- Product
- Methyl 4-chlorocarbonylbenzoate 7377-26-6
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23