SINEFUNGIN
- Product Name
- SINEFUNGIN
- CAS No.
- 58944-73-3
- Chemical Name
- SINEFUNGIN
- Synonyms
- SF;A-9145;rp32232;32232RP;SINEFUNGIN;Sinefungine;SCF from rat;Steel Factor;compound57926;A 9145, RP 32232
- CBNumber
- CB9167377
- Molecular Formula
- C15H23N7O5
- Formula Weight
- 381.39
- MOL File
- 58944-73-3.mol
SINEFUNGIN Property
- alpha
- D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water)
- Boiling point:
- 783.2±70.0 °C(Predicted)
- Density
- 1.91±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- powder
- pka
- pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃)
- color
- white to yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S8559
- Product name
- Sinefungin
- Purity
- 95% (HPLC), powder
- Packaging
- 10mg
- Price
- $640
- Updated
- 2024/03/01
- Product number
- SRP3251
- Product name
- SCF from rat
- Purity
- recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10μG
- Price
- $339
- Updated
- 2023/06/20
- Product number
- 13829
- Product name
- Sinefungin
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $43
- Updated
- 2022/04/27
- Product number
- 13829
- Product name
- Sinefungin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $77
- Updated
- 2022/04/27
- Product number
- 13829
- Product name
- Sinefungin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $292
- Updated
- 2022/04/27
SINEFUNGIN Chemical Properties,Usage,Production
Description
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2?IC50?< 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3?Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4?Inhibits biofilm formation by?Streptococcus pneumoniae.5
Uses
Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.
Uses
Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.
Definition
ChEBI: An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.
General Description
Chemical structure: nucleoside
Biochem/physiol Actions
Probable transcription factor. Plays a critical role in the control of immune response.
References
1) Barbes?et al. (1990),?Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria;? FEMS Microbiol. Lett.,?57?239 2) Yebra?et al. (1991),?The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces;? J. Antibiot. (Tokyo),?44?1141 3) Cheng?et al. (2004),?Small molecule regulators of protein arginine methyltransferases;? J. Biol. Chem.,?279?23892 4) Schluckebier?et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI;? J. Mol. Biol., 265?56 5) Yadav?et al. (2014),?Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth;? Biomed. Res. Int.,?2014?156987
SINEFUNGIN Preparation Products And Raw materials
Raw materials
Preparation Products
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