ChemicalBook > CAS DataBase List > 6-Iodoquinazolin-4-one

6-Iodoquinazolin-4-one

Product Name
6-Iodoquinazolin-4-one
CAS No.
16064-08-7
Chemical Name
6-Iodoquinazolin-4-one
Synonyms
6-Iodoquin;TIMTEC-BB SBB005376;6-Iodoquinazolinone;6-IODO-4-QUINAZOLONE;6-Iodo-4-quinazolinol;6-iodoquinazolin-4-ol;6-lodoquinazolin-4-ol;6-IODOQUINAZOLIN-4-ONE;6-Iodo-4-quinazolinone;6-lodoquinazolin-4-one
CBNumber
CB9168046
Molecular Formula
C8H5IN2O
Formula Weight
272.04
MOL File
16064-08-7.mol
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6-Iodoquinazolin-4-one Property

Melting point:
271°C(lit.)
Boiling point:
401.0±47.0 °C(Predicted)
Density 
2.11±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Solid
pka
1.00±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1S/C8H5IN2O/c9-5-1-2-7-6(3-5)8(12)11-4-10-7/h1-4H,(H,10,11,12)
InChIKey
PUGXMZKDRVGIHC-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(I)C=C2)C(=O)NC=1
CAS DataBase Reference
16064-08-7(CAS DataBase Reference)
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Safety

Risk Statements 
36
Safety Statements 
26
HS Code 
2914390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
I0832
Product name
6-Iodo-4-hydroxyquinazoline
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$59
Updated
2025/07/31
TRC
Product number
I719580
Product name
6-Iodoquinazolin-4-one
Packaging
25g
Price
$1190
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
46875
Product name
6-Iodoquinazolin-4-one
Packaging
2.5g
Price
$650
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0027754
Product name
6-IODOQUINAZOLIN-4-ONE
Purity
95.00%
Packaging
2.5G
Price
$880
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0027754
Product name
6-IODOQUINAZOLIN-4-ONE
Purity
95.00%
Packaging
25G
Price
$2425.5
Updated
2021/12/16
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6-Iodoquinazolin-4-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

6-Iodoquinazolin-4-one is an intermediate in the synthesis of Lapatinib (L175800).

Synthesis

5326-47-6

149-73-5

16064-08-7

Using 2-amino-5-iodobenzoic acid and trimethyl orthoformate as starting materials, the synthesis procedure of Examples I-2 was followed, but the reaction solvent was replaced from methanol to acetonitrile. Upon completion of the reaction, 6-iodoquinazolin-4-one was obtained by post-processing in a yield of 0.98 g and 94% yield.

References

[1] Patent: EP1477481, 2004, A1. Location in patent: Page 17
[2] Patent: EP1477481, 2004, A1. Location in patent: Page 16-17
[3] Patent: EP1477481, 2004, A1. Location in patent: Page 17
[4] Patent: EP1477481, 2004, A1. Location in patent: Page 17
[5] Patent: EP1477481, 2004, A1. Location in patent: Page 17

6-Iodoquinazolin-4-one Preparation Products And Raw materials

Raw materials

Potassium hydroxide Sodium bisulfite Iodine Acetic acid Anthranilic acid Formamide

Preparation Products

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6-Iodoquinazolin-4-one Suppliers

Americas 1 Canada 2 China 202 Europe 1 Germany 1 India 5 Japan 1 The Netherlands 1 United Kingdom 2 United States 22 Global 238
PARAGOS
Tel
--
Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
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View Lastest Price from 6-Iodoquinazolin-4-one manufacturers

Nanjing Fred Technology Co., Ltd
Product
6-Iodoquinazolin-4-one 16064-08-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
6-Iodoquinazolin-4-one 16064-08-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23
LY Global chemicals co.,ltd .
Product
6-Iodoquinazolin-4-one 16064-08-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98.0%min
Supply Ability
100kg
Release date
2023-03-11

16064-08-7, 6-Iodoquinazolin-4-oneRelated Search:

Cefazolin sodium salt Cefazolin Naphazoline hydrochloride 6-Bromoquinazolin-4-ol 6-iodoquinazoline 6-IODO-2,4-DIMETHOXYQUINAZOLINE 6-Iodoquinazolin-4-one N-(6-IODO-8-METHYL-4-OXO-1,4-DIHYDRO-QUINAZOLIN-2-YL)-ISOBUTYRAMIDE 2-IODO-7,8,9,10-TETRAHYDROAZEPINO[2,1-B]QUINAZOLIN-12(6H)-ONE 6-IODO-2-METHYL-1H-QUINAZOLIN-4-ONE SALOR-INT L135879-1EA 6,8-DIIODO-4-QUINAZOLONE ZERENEX E/6026490 2-Ethyl-6-iodo-3-(2-((1-methylethyl)amino)ethyl)-4(3H)-quinazolinone 3-(2-(Ethylamino)ethyl)-6-iodo-2-methyl-4(3H)-quinazolinone 2-AMINO-6-IODO-8-METHYL-1H-QUINAZOLIN-4-ONE

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