MPEP

Product Name: MPEP
CAS No.: 96206-92-7
Chemical Name: MPEP
Synonyms: MPEP;CS-715;MPEP,HCl;MPEP 100MG;MPEP USP/EP/BP;MPEP HYDROCHLORIDE;2-methyl-6-(2-phenylethynyl)pyridine;Pyridine, 2-methyl-6-(2-phenylethynyl)-;6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL;2-METHYL-6-(PHENYLETHYNYL)PYRIDINE HYDROCHLORIDE
CBNumber: CB9171767
Molecular Formula: C14H11N
Formula Weight: 193.24
MOL File: 96206-92-7.mol

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MPEP Property

Melting point:: 45-45.5 °C
Boiling point:: 124.5-126.5 °C(Press: 0.5 Torr)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Off-white powder.
pka: 2.97±0.12(Predicted)
color: White to Off-White
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04635
Product name: MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem
Packaging: 10mg
Price: $218
Updated: 2022/05/15

Tocris

Product number: 1212
Product name: MPEPhydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $150
Updated: 2021/12/16

Tocris

Product number: 1212
Product name: MPEPhydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $611
Updated: 2021/12/16

Usbiological

Product number: 255896
Product name: MPEP hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0076023
Product name: MPEP
Purity: 95.00%
Packaging: 0.5G
Price: $682
Updated: 2021/12/16

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MPEP Chemical Properties,Usage,Production

Uses

A potent, subtype selective mGluR5 antagonist

Uses

2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner.

Uses

MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).

Definition

ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

Biological Activity

Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ .

References

[1] gasparini f, lingenhöhl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, kłodzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430.

MPEP Preparation Products And Raw materials

Raw materials

Preparation Products

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MPEP Suppliers

Canada 1 China 79 Germany 2 Switzerland 2 United Kingdom 7 United States 18 Global 109

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai XIYU Chemical Technology Co.,Ltd.

Tel: 021-61052090 15221126179
Fax: 021-38473230
Country: China
ProdList: 368
Advantage: 55

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2028
Advantage: 58

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View Lastest Price from MPEP manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ifenprodil HeMitartrate 23210-58-4
Price: US $0.00-0.00/mg
Min. Order: 5ASSAYS
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2019-12-30

96206-92-7, MPEPRelated Search:

3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE 2-ETHYNYL-6-METHYL-PYRIDINE 2-ETHYNYLPYRIDINE MPEP

MPEP HYDROCHLORIDE

MPEP

6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL

CS-715

2-METHYL-6-(PHENYLETHYNYL)PYRIDINE HYDROCHLORIDE

MPEP,HCl

MPEP 100MG

2-methyl-6-(2-phenylethynyl)pyridine

Pyridine, 2-methyl-6-(2-phenylethynyl)-

MPEP USP/EP/BP

Metabotropic glutamate receptors,inhibit,MPEP,mGluR,Inhibitor

96206-92-7

C20H22O5S

C14H11NHCl

Glutamate

All Inhibitors

Inhibitors

Neurochemicals

Glutamate receptor

Pyridines, Pyrimidines, Purines and Pteredines