MPEP
- Product Name
- MPEP
- CAS No.
- 96206-92-7
- Chemical Name
- MPEP
- Synonyms
- MPEP;CS-715;MPEP,HCl;MPEP 100MG;MPEP USP/EP/BP;MPEP HYDROCHLORIDE;2-methyl-6-(2-phenylethynyl)pyridine;Pyridine, 2-methyl-6-(2-phenylethynyl)-;6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL;2-METHYL-6-(PHENYLETHYNYL)PYRIDINE HYDROCHLORIDE
- CBNumber
- CB9171767
- Molecular Formula
- C14H11N
- Formula Weight
- 193.24
- MOL File
- 96206-92-7.mol
MPEP Property
- Melting point:
- 45-45.5 °C
- Boiling point:
- 124.5-126.5 °C(Press: 0.5 Torr)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Off-white powder.
- pka
- 2.97±0.12(Predicted)
- color
- White to Off-White
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- 5.04635
- Product name
- MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem
- Packaging
- 10mg
- Price
- $218
- Updated
- 2022/05/15
- Product number
- 1212
- Product name
- MPEPhydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 1212
- Product name
- MPEPhydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $611
- Updated
- 2021/12/16
- Product number
- 255896
- Product name
- MPEP hydrochloride
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- CHM0076023
- Product name
- MPEP
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $682
- Updated
- 2021/12/16
MPEP Chemical Properties,Usage,Production
Uses
A potent, subtype selective mGluR5 antagonist
Uses
2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner.
Uses
MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).
Definition
ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.
Biological Activity
Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ .
References
[1] gasparini f, lingenhöhl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, kłodzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430.
MPEP Preparation Products And Raw materials
Raw materials
Preparation Products
MPEP Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from MPEP manufacturers
- Product
- Ifenprodil HeMitartrate 23210-58-4
- Price
- US $0.00-0.00/mg
- Min. Order
- 5ASSAYS
- Purity
- 99% HPLC
- Supply Ability
- 2000tons
- Release date
- 2019-12-30