ChemicalBook > CAS DataBase List > MPEP

MPEP

Product Name: MPEP
CAS No.: 96206-92-7
Chemical Name: MPEP
Synonyms: MPEP;CS-715;MPEP,HCl;MPEP 100MG;MPEP USP/EP/BP;MPEP HYDROCHLORIDE;MPEP, 10 mM in DMSO;2-methyl-6-(2-phenylethynyl)pyridine;Pyridine, 2-methyl-6-(2-phenylethynyl)-;6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL
CBNumber: CB9171767
Molecular Formula: C14H11N
Formula Weight: 193.24
MOL File: 96206-92-7.mol

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MPEP Property

Melting point:: 45-45.5 °C
Boiling point:: 124.5-126.5 °C(Press: 0.5 Torr)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Off-white powder.
pka: 2.97±0.12(Predicted)
color: White to Off-White
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04635
Product name: MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem
Packaging: 10mg
Price: $218
Updated: 2022/05/15

TCI Chemical

Product number: M3416
Product name: 2-Methyl-6-(phenylethynyl)pyridine
Purity: min. 98.0 %
Packaging: 250MG
Price: $126
Updated: 2025/07/31

TCI Chemical

Product number: M3416
Product name: 2-Methyl-6-(phenylethynyl)pyridine
Purity: min. 98.0 %
Packaging: 1G
Price: $314
Updated: 2025/07/31

Tocris

Product number: 1212
Product name: MPEPhydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $150
Updated: 2021/12/16

Tocris

Product number: 1212
Product name: MPEPhydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $611
Updated: 2021/12/16

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MPEP Chemical Properties,Usage,Production

Uses

A potent, subtype selective mGluR5 antagonist

Uses

2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner.

Uses

MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).

Definition

ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

Biological Activity

Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ .

in vivo

MPEP (1-30 mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice^[2].
MPEP (1-20 mg/kg) does shorten the immobility time in a tail suspension test in mice, however it is inactive in the behavioural despair test in rats^[2].
MPEP (30 mg/kg i.p.) slightly but significantly increases (by 39%) the number of punished crossings in the four-plate test, lower doses of the compound (3 and 10 mg/kg) does not affect the number of punished crossings in that test (F (3,36)=3.240, P<0.05)^[2].
MPEP (1, 10 and 20 mg/kg) significantly (by 55% after the highest dose), (F(3,28)=15.47, P<0.001) decreases the immobility time of mice in the tail suspension test. Its efficacy is similar to that of imipramine (20 mg/kg), used as the positive standard^[2].

Animal Model:	Male Wistar rats (200 ± 250 g)^[2].
Dosage:	IP or PO.
Administration:	0.3, 1 and 10 mg/kg, i.p. (Conflict drinking test).
Result:	At a dose of 0.3 mg/kg was not ffective, at doses of 1 and 10 mg/kg i.p. significantly (F (3,30)=11.193, P<0.001), increased the number of shocks (by 330 and 507%, respectively) accepted during the experimental session in the Vogel test.

Animal Model:	Male Wistar rats (200 ± 250 g)^[2].
Dosage:	IP or PO.
Administration:	1, 3 and 10 mg/kg, i.p. or 10 and 30 mg/kg, p.o.(Elevated plus-maze test).
Result:	Administered at a dose of 1 mg kg71 i.p. did not change the entries into and time spent in the open arms. At doses of 3 and 10 mg/kg i.p. significantly (F (3,24)=22.978, P<0.001) dose-dependently increased the time spent in the open arms (up to 45 and 74%, respectively), and the percentage of entries into the open arms (up to 48 and 68%, respectively, F(3,24)=5.678, P<.01). At doses of 3 and 10 mg/kg i.p. significantly increased (by 64%) the total number of entries and reduced (by about 25%) the total time spent (data not shown) in the arms (either type). At the dose of 30 mg/kg (po, but not 10 mg/kg) significantly (up to 64%, F (2,16)=14.249, P<0.001) increased the percentage of the time spent in the open arms and the percentage of entries into the open arms (up to 63%, F (2,16)=7.295, P<0.01). MPEP given p.o. in both doses used did not change the total number of entries nor the total time spent in the arms (either type).

IC 50

mGluR5: 36 nM (IC₅₀)

References

[1] gasparini f, lingenhöhl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, kłodzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430.

MPEP Preparation Products And Raw materials

Raw materials

Preparation Products

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MPEP Suppliers

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View Lastest Price from MPEP manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ifenprodil HeMitartrate 23210-58-4
Price: US $0.00-0.00/mg
Min. Order: 5ASSAYS
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2019-12-30

96206-92-7, MPEPRelated Search:

3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE 2-ETHYNYL-6-METHYL-PYRIDINE 2-ETHYNYLPYRIDINE MPEP

MPEP HYDROCHLORIDE

MPEP

6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL

CS-715

2-METHYL-6-(PHENYLETHYNYL)PYRIDINE HYDROCHLORIDE

MPEP,HCl

MPEP 100MG

2-methyl-6-(2-phenylethynyl)pyridine

Pyridine, 2-methyl-6-(2-phenylethynyl)-

MPEP USP/EP/BP

Metabotropic glutamate receptors,inhibit,MPEP,mGluR,Inhibitor

MPEP, 10 mM in DMSO

96206-92-7

C20H22O5S

C14H11NHCl

Glutamate

All Inhibitors

Inhibitors

Neurochemicals

Glutamate receptor

Pyridines, Pyrimidines, Purines and Pteredines