ChemicalBook > CAS DataBase List > 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE

3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE

Product Name: 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE
CAS No.: 23821-37-6
Chemical Name: 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE
Synonyms: 4-(2-Cyanoacetyl)pyridine;b-oxo-4-Pyridinepropanenitrile;4-Pyridinepropanenitrile, β-oxo-;Beta-oxo-4-pyridinepropanenitrile;3-Oxo-3-(4-pyridyl)propanenitrile;3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE;3-OXO-3-PYRIDIN-4-YLPROPANENITRILE;3-OXO-4-PYRIDIN-3-YL-PROPIONITRILE;3-Oxo-3-(4-pyridinyl)propanenitrile;3-oxo-3-(yridine-4-yl)propanenitrile
CBNumber: CB9173983
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 23821-37-6.mol

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3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE Property

Boiling point:: 335.3±22.0 °C(Predicted)
Density: 1.177±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 6.29±0.10(Predicted)
Appearance: Light yellow to orange Solid

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Safety

Hazard Codes: T,Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: O859218
Product name: 3-Oxo-3-(pyridin-4-yl)propanenitrile
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR2995
Product name: 3-Oxo-3-(pyridin-4-yl)propanenitrile
Packaging: 1g
Price: $95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-1-W8
Product name: 3-Oxo-3-pyridin-4-ylpropanenitrile
Packaging: 1g
Price: $212
Updated: 2021/12/16

Matrix Scientific

Product number: 085233
Product name: 3-Oxo-3-pyridin-4-ylpropanenitrile
Purity: 98%
Packaging: 1g
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: W4748
Product name: 3-Oxo-3-pyridin-4-yl-propionitrile
Packaging: 5g
Price: $505
Updated: 2021/12/16

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3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE Chemical Properties,Usage,Production

Synthesis

2459-09-8

75-05-8

23821-37-6

3-Oxo-3-(4-pyridyl)propionitrile was synthesized from methyl isonicotinate and acetonitrile according to the improved scheme of route A1. The procedure was as follows: 3 g (22 mmol) of methyl isonicotinate was dissolved in 30 mL of anhydrous toluene under nitrogen protection, and 1.75 g (44 mmol) of 50-60% NaH (dispersed in mineral oil) was slowly added. Subsequently, 5.39 mL (103 mmol) of dry acetonitrile was added slowly and dropwise at 90 °C. The reaction mixture was heated and refluxed for 18 hours, during which the product precipitated as sodium salt. After completion of the reaction, it was cooled to room temperature and the solid product was collected by filtration. The solid was dissolved in water, the pH was adjusted to 5-6 with 6N HCl solution and the product was extracted with dichloromethane (DCM). The aqueous phase was again pH adjusted to 4-5 and a secondary extraction with DCM was performed to recover more product. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product in 58% yield. The crude product can be used directly in the subsequent reaction.

References

[1] Patent: WO2008/87529, 2008, A1. Location in patent: Page/Page column 113
[2] Patent: WO2007/98826, 2007, A2. Location in patent: Page/Page column 47-48
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6890 - 6892
[4] Patent: WO2006/84015, 2006, A2. Location in patent: Page/Page column 86-87
[5] Patent: WO2010/9290, 2010, A1. Location in patent: Page/Page column 143-144

3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE manufacturers

Career Henan Chemical Co

Product: 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE 23821-37-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-20

23821-37-6, 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILERelated Search:

3-Oxetanone 3-oxaspiro[5.5]undecan-9-one 2-(3-CHLOROPHENYL)-3-OXO-3-PYRIDIN-3-YL-PROPIONITRILE 3-OXO-3-PYRIDIN-3-YL-PROPIONITRILE 3-OXO-3-PYRIDIN-2-YL-PROPIONITRILE,3-OXO-2-PYRIDIN-3-YL-PROPIONITRILE [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER 3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE 4-Pyridinepropanenitrile

3-OXO-3-PYRIDIN-4-YLPROPANENITRILE

3-OXO-3-PYRIDIN-4-YL-PROPIONITRILE

4-Pyridinepropanenitrile, β-oxo-

3-Oxo-3-(4-pyridyl)propanenitrile

3-Oxo-3-(4-pyridinyl)propanenitrile

3-OXO-4-PYRIDIN-3-YL-PROPIONITRILE

4-(2-Cyanoacetyl)pyridine

Beta-oxo-4-pyridinepropanenitrile

3-oxo-3-(yridine-4-yl)propanenitrile

b-oxo-4-Pyridinepropanenitrile

4-Pyridinepropanenitrile, .beta.-oxo-

3-Oxo-3-(pyridin-4-yl)propionitrile, 4-(Cyanoacetyl)pyridine

23821-37-6

23821-27-6

API intermediates

Pyridines