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Liensinine

Product Name
Liensinine
CAS No.
2586-96-1
Chemical Name
Liensinine
Synonyms
Hiensinine;LIENSININE;Liensinine USP/EP/BP;Liensinine perchlorafe;Phenol,4-[[(1R)-1,2,3,4-tetrahydro-6, 7-dimethoxy-;2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-(((R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol;4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol;Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-
CBNumber
CB9179455
Molecular Formula
C37H42N2O6
Formula Weight
610.74
MOL File
2586-96-1.mol
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Liensinine Property

Melting point:
95-99 °C
Boiling point:
722.0±60.0 °C(Predicted)
Density 
1.218±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Acetone (Slightly), Chloroform (Slightly)
form 
Solid
pka
9.28±0.45(Predicted)
color 
White to Off-White
InChIKey
XCUCMLUTCAKSOZ-FIRIVFDPSA-N
SMILES
C1(O)=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC1=CC=C(O)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
L0432
Product name
Liensinine
Packaging
10MG
Price
$208
Updated
2025/07/31
TRC
Product number
L397833
Product name
Liensinine
Packaging
10mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL65625
Product name
Liensinine
Packaging
25mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL65625
Product name
Liensinine
Packaging
5mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FL65625
Product name
Liensinine
Packaging
10mg
Price
$80
Updated
2021/12/16
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Liensinine Chemical Properties,Usage,Production

Description

The isomer of isoliensinine (q.v.), this alkaloid is present in the embryo of the seeds of Nelumbo nucifera Gaertn.

Chemical Properties

Soluble in chloroform, methanol and ethanol, insoluble in ether and water. Derived from the germ of mature seeds of lotus (Nelumbo nucifera Gaevth.), Water lily family.

Uses

Liensinine is a bisbenzylisoquinoline alkaloid with inhibitory properties towards the activation of microglial cells. In testing with rats, iensinine decreased epileptic discharges were observed on electrocorticograms.

Definition

ChEBI: Liensinine is a member of isoquinolines.

in vivo

Liensinine (oral gavage, 100 or 200 mg/kg, daily, 10 weeks) can effectively treat periodontitis, similar to metronidazole-type drugs, and has a certain dose-dependent[2].

Animal Model:KM mice[2]
Dosage:100 mg/kg, 200 mg/kg
Administration:oral gavage, daily, 10 weeks
Result:Reduced the gingival index and increased the SOD levels, the CAT, GSH-Px levels and decreased the NO, MDA, and ET levels compared to the control group.
Animal Model:Institute of Cancer Research (ICR) mice (male, 20-22 g)[3]
Dosage:
Administration:5 mg/kg by oral administration; 1 mg/kg by intravenous administration
Result:The pharmacokinetic parameters of Liensinine in mice
Parameterspo (5 mg/kg)iv (1 mg/kg)
AUC(0-t) (ng/mL*h)18.8 ± 2.7211.2 ± 54.9
AUC(0-∞) (ng/mL*h)19.1 ± 2.8227.9 ± 60.1
MRT(0-t)( h)3.2 ± 0.42.6 ± 0.5
MRT(0-∞) (h)3.4 ± 0.53.5 ± 0.9
t1/2z (h)1.9 ± 0.23.8 ± 0.8
CLz/F (L/h/kg)266.0 ± 41.34.7 ± 1.2
Vz/F (L/kg)708.5 ± 79.925.9 ± 11.0
Cmax (ng/mL)5.3 ± 0.2169.5 ± 53.5

References

Tse-yuan et al., Sci. Sinica., 11, 215 (1962)
Pei-chuanetal., ibid, 11,321 (1962)

Liensinine Preparation Products And Raw materials

Raw materials

Preparation Products

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Liensinine Suppliers

China 212 Germany 1 United Kingdom 4 United States 11 Global 228
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
Chengdu Nakeli Biotechnology Co., Ltd.
Tel
028-61983833 19138982515
Fax
3265827856
Email
3265827856@qq.com
Country
China
ProdList
1581
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
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View Lastest Price from Liensinine manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Liensinine 2586-96-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-24
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
Product
Liensinine
Price
US $10.00/KG
Min. Order
1KG
Purity
5%
Supply Ability
100KG
Release date
2021-07-28
Shanghai Standard Technology Co., Ltd.
Product
Liensinine 2586-96-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-28

2586-96-1, LiensinineRelated Search:

ELEUTHEROSIDE A Sophoridine Dihydromyrcenol Basic Violet 1 Kresoxim-methyl Methyl acrylate Acetonitrile Methylparaben Paraquat dichloride Methanol Methyl Liensinine perchlorate Isoliensinine Neferine Liensinine HClO 4 Nefrine perchlorate Liensinine Dimethoxy

  • 4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol
  • LIENSININE
  • Hiensinine
  • Liensinine 4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
  • 2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-
  • Phenol,4-[[(1R)-1,2,3,4-tetrahydro-6, 7-dimethoxy-
  • 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
  • Liensinine perchlorafe
  • Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-
  • Liensinine USP/EP/BP
  • 4-(((R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol
  • 2586-96-1
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract