(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

Product Name: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde
CAS No.: 15186-48-8
Chemical Name: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde
Synonyms: 2,3-O-ISOPROPYLIDENE-D-GLYCERALDEHYDE;(4R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBALDEHYDE;NSC 89869;EOS-61843;ane-4-carboxaL;4-carboxaldehyde;R-(+)-Solketaldehyde;(R)-(+)-2,2-Dimethyl;Gemcitabine Impurity 17;R-glyceraldehyde acetal
CBNumber: CB9184468
Molecular Formula: C6H10O3
Formula Weight: 130.14
MOL File: 15186-48-8.mol

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(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde Property

Boiling point:: 139 °C (lit.)
alpha: 53.8 º (c=2, CHCl3)
Density: 1.045 g/mL at 25 °C (lit.)
refractive index: n20/D 1.454(lit.)
Flash point:: 143 °F
storage temp.: -20°C
solubility: Difficult to mix.
form: Liquid
color: Colorless to Pale Yellow
optical activity: [α]22/D +53.8°, c = 2 in chloroform
InChI: InChI=1S/C6H10O3/c1-6(2)8-4-5(3-7)9-6/h3,5H,4H2,1-2H3/t5-/m0/s1
InChIKey: YSGPYVWACGYQDJ-YFKPBYRVSA-N
SMILES: O1C[C@H](C=O)OC1(C)C
CAS DataBase Reference: 15186-48-8(CAS DataBase Reference)
NIST Chemistry Reference: Acetone D-glyceraldehyde(15186-48-8)

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Safety

WGK Germany: 3
HazardClass: 6.1
HS Code: 29329990
Storage Class: 10 - Combustible liquids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H303May be harmfulif swallowed

H333May be harmful if inhaled

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 454486
Product name: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde
Packaging: 500mg
Price: $86.94
Updated: 2025/07/31

Usbiological

Product number: 293777
Product name: 2,3-O-Isopropylidene-D-glyceraldehyde
Packaging: 5g
Price: $322
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: O106912
Product name: 2-3-O-Isopropylidene-D-glyceraldehyde-50%solutioninDCM
Packaging: 25g
Price: $395
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MI09388
Product name: 2,3-O-Isopropylidene-D-glyceraldehyde - 50% solution in DCM
Packaging: 250g
Price: $425
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MI09388
Product name: 2,3-O-Isopropylidene-D-glyceraldehyde - 50% solution in DCM
Packaging: 50g
Price: $175
Updated: 2021/12/16

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(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde Chemical Properties,Usage,Production

Chemical Properties

Colorless Transparent Liquid

Uses

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde_x000D__x000D_Discontinued, Unstable (cas# 15186-48-8) is a compound useful in organic synthesis.

Uses

Reactant involved in organic reactions including:

Henry condensation reactions
Synthesis of highly functionalized chiral aziridines
Olefination of aldehydes
C-H oxidations
Aldol-type condensations
Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents
Hosomi-Sakurai reactions

Uses

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde is a reactant involved in organic reactions including:• ;Henry condensation reactions1• ;Synthesis of highly functionalized chiral aziridines2• ;Olefination of aldehydes3• ;C-H oxidations4• ;Aldol-type condensations5• ;Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents6• ;Hosomi-Sakurai reactions7

Synthesis

Add 220g of dichloromethane, 23g of bisacetone-D-mannitol, 0.23g of 18-crown-6-ether, and 0.4g of TEMPO to the clean reactor. 0.4g, stirring and mixing well, then slowly lower the temperature to 10 ??, began to drop the mass percentage of 10wt% of sodium hypochlorite aqueous solution of 72g, drop the process of controlling the temperature of the reaction system in the process of 15 ?? or less, drop after the completion of the reaction to continue the reaction so that the temperature of the temperature in the range of 30 ?? ~ 32 ?? under the conditions of insulation for oxidation reaction 1h, the end of the reaction, static, delamination, to remove the aqueous layer, the collection of the organic layer with 50g of water washed once, layered to remove the water layer, the organic layer collected by adding 20g of anhydrous sodium sulfate and stirring for drying treatment for 30min, filtration, collection of filtrate, the filtrate will be concentrated under reduced pressure to remove the solvent, the wet product obtained after baking, to obtain the dry product (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde 22.1g, yield 97%, the content of the gas phase was 99.2%.

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde Suppliers

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View Lastest Price from (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde 15186-48-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-18

Shaanxi Dideu New Materials Co. Ltd

Product: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde 15186-48-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

Handan Tongyi New Material Technology Co., Ltd

Product: (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde 15186-48-8
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99.99%
Supply Ability: 500 Metric Ton/Day
Release date: 2021-03-02

15186-48-8, (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehydeRelated Search:

1,3-Dioxolane Dimethyl ether ETHANE Dimethyl carbonate Dacthal 1,4-Dioxane Dimethyl sulfate N,N-Dimethylformamide Dimethyl disulfide Dimethyl fumarate Dimethyl sulfoxide 2,3-O-ISOPROPYLIDENE-D-ERYTHRONOLACTONE Methyl (4R,5S)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylate Dikegulac sodium 5-BROMO-5-DEOXY-2,3-O-ISOPROPYLIDENE-D-RIBONOLACTONE (4R,5R)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER 2,3-O-Isopropylidene-D-ribonic gamma-lactone (R)-(+)-2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBOXYLIC ACID METHYL ESTER

1,3-DIOXOLANE-4-CARBOXALDEHYDE, 2,2-DIMETHYL-, (R)-

(R)-2,2-DIMETHYL-[1,3]DIOXOLANE-4-CARBALDEHYDE

(R)-(+)-2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBOXALDEHYDE

(R)-2,3-ISOPROPYLIDENE GLYCERALDEHYDE

2,3-O-ISOPROPYLIDENE-D-GLYCERALDEHYDE

2,3-O-(R)-ISOPROPYLIDENE-L-GLYCERALDEHYDE

(4R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBALDEHYDE

D-(R)-GLYCERALDEHYDE ACETONIDE

R-(+)-Solketaldehyde

D-Glyceraldehyde-acetonide

R-Glyceraldehyde-acetonide

( R)-(+)-2,2-dimethyl-1,3-dioxolan-4-carboxaldehyde

(R)-(+)-2,2-Dimethyl-1,3-Dioxylane-4-Carboxadehyde

R-(+)-2,3-O-Isopropylidene-D-glyceraldehyd

(R)-(+)-2,2-Dimethyl-1,3-Dioxo

(R)-(+)-2,2-DIMETHYL-1,3-DIOXOLANE-4

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehydeDiscontined, Unstable

(R)-(+)-2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBOXALDEHYDE(INTERMEDIATEOFGEMCITABINE)

R-(+)-2,3-O-Isopropylidene-D-glyceraldehyde

(R)-2,2-DiMethyl-1,3-dioxolane-4-carboxaldehyde) 50% in Methylene chloride

(R)-(+)-2,2-DiMethyl-1,3-dioxolane-4-carboxaldehyde, 97%,50% in DichloroMethane

(4R)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde,98%

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde Discontinued, Unstable

(R)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde(needs distilling as oligomeric form)

(R)-(+)-2,2-Dimethyl

2,3-O-(R)-Isopropylidene-D-glyceraldehyde - 50% DCM solution

(R)-Isopropylideneglyceraldehyde

NSC 89869

EOS-61843

(R)-acetone glyceraldehyde

Gemcitabine Impurity 17

2,3-isopropylidene-glyceraldehyde

R-glyceraldehyde acetal

2,3-O-Isopropylidene-D-glyceraldehyde - 50% solution in DCM

4-carboxaldehyde

ane-4-carboxaL

1,3-Dioxolane-4-carboxaldehyde, 2,2-dimethyl-, (4R)-

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde ISO 9001：2015 REACH

(R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde(50% in Chlorocyclohexane)

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, 97%,

2, 3-0-isopropyli dene-D-glyceral dehyde

(R) - (+) -2,2-dimethyl-1,3-dioxolane-4-formaldehyde

(R)-(+)-2, 2-dimethyl-1, 3-dioxopentyclo-4-formaldehyde

D-(R)-Glyceraldehyde acetonide (R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde

(R)-2,2-DIMETHYL-,3]DIOXOLANE-4-CARBALDEHYDE

(<i>R</i>)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

(R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde(50% in Chlorocyclohexane),50% in Chlorocyclohexane

15186-48-8

Aldehydes

Organic Building Blocks

Chiral Building Blocks

Asymmetric Synthesis

Building Blocks

C1 to C6

Carbonyl Compounds

Chemical Synthesis