PROGLUMETACIN MALEATE

Product Name: PROGLUMETACIN MALEATE
CAS No.: 57132-53-3
Chemical Name: PROGLUMETACIN MALEATE
Synonyms: PROGLUMETACIN;Proglumetacine;PROGLUMETACIN MALEATE;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI);1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
CBNumber: CB9188310
Molecular Formula: C46H58ClN5O8
Formula Weight: 844.43
MOL File: 57132-53-3.mol

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PROGLUMETACIN MALEATE Property

solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form: Solid
color: White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 287563
Product name: Proglumetacin
Packaging: 5mg
Price: $433
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008070
Product name: PROGLUMETACIN
Purity: 95.00%
Packaging: 100MG
Price: $739.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008070
Product name: PROGLUMETACIN
Purity: 95.00%
Packaging: 1G
Price: $1871.1
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008070
Product name: PROGLUMETACIN
Purity: 95.00%
Packaging: 10MG
Price: $225.75
Updated: 2021/12/16

AK Scientific

Product number: H841
Product name: Proglumetacin
Packaging: 10mg
Price: $347
Updated: 2021/12/16

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PROGLUMETACIN MALEATE Chemical Properties,Usage,Production

Uses

Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.

Definition

ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy -alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor effects that helps prevent injury to the stomach lining.

Synthesis

The reaction of N-benzoyl-N_x0002_, N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine obtained from 1-(2-hydroxyethyl)piperazine and 1-bromo-3-chloropropane by means of sodium methanolate in DMSO at 105?C gives N--N_x0002_-(2-hydroxyethyl) piperazine, which is then condensated with Indomethacin (1-(p-chlorobenzoyl)- 5-methoxy-2-methylindole-3-acetic acid) by means of dicyclohexylcabodiimide and NaHCO3 in ethyl acetate .

PROGLUMETACIN MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PROGLUMETACIN MALEATE Suppliers

China 11 Europe 1 India 1 United Kingdom 2 United States 7 Global 22

J & K SCIENTIFIC LTD.

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Pure Chemistry Scientific Inc.

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Wuhan Dahua Pharmaceutical Co., Ltd.

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Amadis Chemical Company Limited

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Shenzhen SUNGENING Bio-Medical Co., Ltd.

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Capot Chemical Co.,Ltd.

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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57132-53-3, PROGLUMETACIN MALEATERelated Search:

Ethyl 3-indoleacetate PROGLUMETACIN MALEATE 5-Methoxyindole-3-acetic acid 1-METHYL-3-INDOLEACETIC ACID 5-HYDROXYINDOLE-3-ACETIC ACID 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID 2-METHYLINDOLE-3-ACETIC ACID Indometacin Delmetacin 5-HYDROXYTRYPTOPHOL 5-METHOXYTRYPTOPHOL Proglumide 1-Acetyl-5-methoxyindole 1-[2-(1-PROPYL)-OXYETHYL]-PIPERAZINE 1-Ethyl-5-methoxyindole 1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER ETHYL 2-METHYL-3-INDOLEACETATE (5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER

PROGLUMETACIN

PROGLUMETACIN MALEATE

Proglumetacine

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI)

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester

57132-53-3

59209-48-4

C46H58ClN5O8