ChemicalBook > CAS DataBase List > (S)-3-Hydroxypyrrolidine
(S)-3-Hydroxypyrrolidine
- Product Name
- (S)-3-Hydroxypyrrolidine
- CAS No.
- 100243-39-8
- Chemical Name
- (S)-3-Hydroxypyrrolidine
- Synonyms
- (S)-PYRROLIDIN-3-OL;S-HP;(S)-3-PyrroL;(S)-3-PYRROLIDINOL;(+)-3-Pyrrolidinol;3-PYRROLIDINOL, (S);(3S)-3-Pyrrolidinol;(S)-Pyrrolidine-3-ol;(3S)-Pyrrolidin-3-ol;(3S)-Pyrrolidine-3-ol
- CBNumber
- CB9195781
- Molecular Formula
- C4H9NO
- Formula Weight
- 87.12
- MOL File
- 100243-39-8.mol
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(S)-3-Hydroxypyrrolidine Property
- Melting point:
- 15°C
- Boiling point:
- 108-110 °C (8 mmHg)
- alpha
- -6.5 º (c=3.5% in MeOH)
- Density
- 1.078 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.490
- Flash point:
- >110°C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 14.91±0.20(Predicted)
- form
- Liquid After Melting
- color
- Clear light yellow to yellow
- Specific Gravity
- 1.078
- optical activity
- [α]20/D 6.5±1.5°, c = 3.5% in methanol
- Water Solubility
- Fully miscible in water.
- Sensitive
- Air Sensitive & Hygroscopic
- BRN
- 4652606
- CAS DataBase Reference
- 100243-39-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-40
- Safety Statements
- 26-37/39-36-22
- WGK Germany
- 3
- F
- 10-34
- HS Code
- 29339900
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 56437
- Product name
- (S)-3-Pyrrolidinol
- Purity
- ≥97.0% (sum of enantiomers, GC)
- Packaging
- 5ml
- Price
- $320.8
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 56437
- Product name
- (S)-3-Pyrrolidinol
- Purity
- ≥97.0% (sum of enantiomers, GC)
- Packaging
- 1ml
- Price
- $220
- Updated
- 2023/06/20
TCI Chemical
- Product number
- P1667
- Product name
- (S)-3-Pyrrolidinol
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $54
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P1667
- Product name
- (S)-3-Pyrrolidinol
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $149
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L19498
- Product name
- (S)-(-)-3-Hydroxypyrrolidine, 99%, ee 99%
- Packaging
- 1g
- Price
- $153.65
- Updated
- 2024/03/01
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(S)-3-Hydroxypyrrolidine Chemical Properties,Usage,Production
Description
(S)-3-Hydroxypyrrolidine is a chiral organic compound that serves as an important building block in the synthesis of various pharmaceuticals and natural products. It is a four-membered heterocyclic amino alcohol, featuring a hydroxyl group and a stereogenic center. The 'S' prefix indicates the configuration at the stereocenter, which is crucial for its reactivity and biological activity. This compound is notable for its role as an intermediate in the synthesis of drugs, particularly those targeting the central nervous system. The enantiomeric purity of (S)-3-Hydroxypyrrolidine is often critical, as the 'R' and 'S' enantiomers can exhibit different pharmacological properties.
Chemical Properties
clear light yellow to yellow liquid after melting
Uses
(S)-(-)-3-Hydroxypyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(S)-3-Hydroxypyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-3-Hydroxypyrrolidine manufacturers
Nanjing Fred Technology Co., Ltd
- Product
- (S)-3-Hydroxypyrrolidine 100243-39-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-26
Hebei Yanxi Chemical Co., Ltd.
- Product
- (S)-3-Hydroxypyrrolidine 100243-39-8
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-19
Hebei Kingfiner Technology Development Co.Ltd
- Product
- (S) 3-hydroxypyrrolidine 100243-39-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-12-20
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