ChemicalBook > CAS DataBase List > 3-Nitrosalicylaldehyde

3-Nitrosalicylaldehyde

Product Name: 3-Nitrosalicylaldehyde
CAS No.: 5274-70-4
Chemical Name: 3-Nitrosalicylaldehyde
Synonyms: 2-HYDROXY-3-NITROBENZALDEHYDE;NSC 38026;AKOS B029850;3-nitrosalicaldehyde;3-NITROSALICYLALDEHYDE;LABOTEST-BB LT00939229;2-formyl-6-nitrophenolate;3-Nitrosalicylaldehyde>salicylaldehyde, 3-nitro-;3-Nitrosalicylaldehyde,98%
CBNumber: CB9199158
Molecular Formula: C7H5NO4
Formula Weight: 167.12
MOL File: 5274-70-4.mol

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3-Nitrosalicylaldehyde Property

Melting point:: 105-109 °C(lit.)
Boiling point:: 295.67°C (rough estimate)
Density: 1.5216 (rough estimate)
refractive index: 1.6280 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: Crystalline Powder
pka: 5.07±0.24(Predicted)
color: Yellow to brown
Water Solubility: slightly soluble
Sensitive: Air Sensitive
CAS DataBase Reference: 5274-70-4(CAS DataBase Reference)
NIST Chemistry Reference: Benzaldehyde, 2-hydroxy-3-nitro-(5274-70-4)
EPA Substance Registry System: Benzaldehyde, 2-hydroxy-3-nitro- (5274-70-4)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22-20/21/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3
TSCA: Yes
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 527424
Product name: 2-Hydroxy-3-nitrobenzaldehyde
Purity: 98%
Packaging: 1g
Price: $35.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 527424
Product name: 2-Hydroxy-3-nitrobenzaldehyde
Purity: 98%
Packaging: 5g
Price: $53.5
Updated: 2024/03/01

TCI Chemical

Product number: N0823
Product name: 3-Nitrosalicylaldehyde
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: N0823
Product name: 3-Nitrosalicylaldehyde
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $192
Updated: 2025/07/31

TRC

Product number: H949860
Product name: 2-Hydroxy-3-nitrobenzaldehyde
Packaging: 250mg
Price: $250
Updated: 2021/12/16

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3-Nitrosalicylaldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow to brown crystalline powder

Uses

2-Hydroxy-3-nitrobenzaldehyde may be used in the synthesis of 5-acetyl-4-aryl-6-methyl-1,2,3,4-tetrahydro pyrimidine.

General Description

2-Hydroxy-3-nitrobenzaldehyde can be extracted from the leaves of Actephila merrilliana. Its molecule is planar. On reaction with dapsone, it affords a colorless solution.

Synthesis

90-02-8

5274-70-4

GENERAL METHOD: Salicylaldehyde (10 mmol) was mixed with urea nitrate (10 mmol) in acetonitrile-water solvent mixture (95:5, 5 ml, v/v) in a 25 ml round bottom flask. The reaction mixture was placed in a Milestone Start SYNTH microwave reactor and heated at 80°C for 40-50 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature, quenched with water and extracted with dichloromethane. The organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford the target product 3-nitrosalicylaldehyde. In all experiments, o-nitrosalicylaldehyde was selectively generated and no para-nitro-substituted by-products were detected. The resulting compounds were characterized by 1H NMR, 13C NMR, melting point determination (for solid samples), GC-MS analysis and comparison with standards.

References

[1] Chinese Chemical Letters, 2010, vol. 21, # 4, p. 403 - 406
[2] Synthetic Communications, 2011, vol. 41, # 20, p. 2985 - 2992
[3] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1320 - 1322
[4] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57-58
[5] Tetrahedron, 1969, vol. 25, p. 3251 - 3266

3-Nitrosalicylaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Nitrosalicylaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Nitrosalicylaldehyde 5274-70-4
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: 3-Nitrosalicylaldehyde 5274-70-4
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 98%
Supply Ability: 1kg,2kg,100kg
Release date: 2019-07-09

5274-70-4, 3-NitrosalicylaldehydeRelated Search:

5-Methylsalicylaldehyde 4-Nitrobenzoic acid 3-NITRO BENZALDEHYDE CHLOROPHOSPHONAZO III 4-Hydroxy-3-nitrobenzaldehyde 3-Nitrobenzaldehyde 4-Hydroxybenzaldehyde 4-Nitrobenzaldehyde 3-Nitrotoluene Salicylaldehyde 2,4,6-Trinitrotoluene Nitromethane Nitrobenzene 2-NITROSALICYLALDEHYDE,2-HYDROXY 5-NITROBENZALDEHYDE/5-NITROSALICYLALDEHYDE,5-NITROSALICYLALDEHYDE,2-Hydroxy5-Nitrobenzaldehyae(5-nitrosalicylaldehyde 5-METHOXY-3-NITROSALICYLALDEHYDE 97%,5-METHOXY-3-NITROSALICYLALDEHYDE 3-Nitrosalicylic acid 3,5-Dinitrosalicylic acid 2,6-DIMETHOXY-3-NITROBENZOIC ACID

2-hydroxy-3-nitro-benzaldehyd

LABOTEST-BB LT00939229

2-HYDROXY-3-NITROBENZALDEHYDE

3-NITROSALICYLALDEHYDE

AKOS B029850

3-nitro-2-hydroxybenzaldehyde

3-nitrosalicaldehyde

3-Nitrosalicylaldehyde, 98% 1GR

3-Nitrosalicylaldehyde,98%

NSC 38026

Benzaldehyde,2-hydroxy-3-nitro-

2-formyl-6-nitrophenolate

3-Nitrosalicylaldehyde&gt

salicylaldehyde, 3-nitro-

5274-70-4

Carbonyl Compounds

Building Blocks

Aldehydes

Organic Building Blocks

Aromatic Aldehydes & Derivatives (substituted)

organic synthesis and intermediates

Benzaldehyde