5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Property

Melting point:

169-173 °C

Boiling point:

424.2±40.0 °C(Predicted)

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

-1.15±0.10(Predicted)

form 

solid

Appearance

Light brown to yellow Solid

Safety

Hazard Codes 

Xn

Risk Statements 

22-37/38-41-36/37/38-20/21/22

Safety Statements 

26-36/39-36/37/39-22

RIDADR 

UN3439

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29331990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Synthesis

GENERAL METHOD: 4-Chlorophenylhydrazine (0.001 mol) was mixed with 10 mL of ethanol, stirred and heated to reflux. Subsequently, ethoxymethylene malononitrile (0.001 mol) dissolved in 10 mL of ethanol was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. After completion of the reaction, the mixture was poured into 50 mL of ice water. The precipitate precipitated was collected by filtration and washed with cold water to afford 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile in 61-80% yield.

References

[1] Heterocyclic Communications, 2005, vol. 11, # 5, p. 385 - 388
[2] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1876 - 1884
[3] European Journal of Medicinal Chemistry, 2008, vol. 43, # 4, p. 771 - 780
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2892 - 2898
[5] Australian Journal of Chemistry, 1989, vol. 42, # 5, p. 747 - 750