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DCPIB

Product Name
DCPIB
CAS No.
82749-70-0
Chemical Name
DCPIB
Synonyms
DCPIB;4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID;4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid;4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-5-indanyl)oxy]butanoic Acid;4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid;4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID;Butanoic acid, 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-;Cl-Channels,Chloride Channel,cardiomyocytes,DCPIB,ischemia,COS-7,KcsA,Potassium Channel,CPAE cell,Inhibitor,inhibit,swelling,rMCAO
CBNumber
CB9215009
Molecular Formula
C22H28Cl2O4
Formula Weight
427.36
MOL File
82749-70-0.mol
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DCPIB Property

Boiling point:
593.8±50.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO
form 
solid
pka
4.53±0.10(Predicted)
color 
White
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Safety

Hazard Codes 
T
Risk Statements 
25-41
Safety Statements 
26-36/39-45
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
1540
Product name
DCPIB
Purity
≥98%(HPLC)
Packaging
50
Price
$675
Updated
2021/12/16
Tocris
Product number
1540
Product name
DCPIB
Purity
≥98%(HPLC)
Packaging
10
Price
$160
Updated
2021/12/16
TRC
Product number
D195150
Product name
DCPIB
Packaging
100mg
Price
$1105
Updated
2021/12/16
Usbiological
Product number
255115
Product name
DCPIB
Packaging
10mg
Price
$403
Updated
2021/12/16
ChemScene
Product number
CS-0027766
Product name
DCPIB
Purity
99.81%
Packaging
50mg
Price
$550
Updated
2021/12/16
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DCPIB Chemical Properties,Usage,Production

Uses

DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.

Definition

ChEBI: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid is a member of indanones.

Biological Activity

Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .

storage

Store at +4°C

DCPIB Preparation Products And Raw materials

Raw materials

Preparation Products

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DCPIB Suppliers

China 44 Germany 2 Switzerland 1 United Kingdom 2 United States 11 Global 60
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82749-70-0, DCPIBRelated Search:

2,3-Dichloro-4-hydroxybenzaldehyde 6-CHLORO-1-INDANONE 96 7-CHLORO-1-INDANONE 2-CHLORO-4,5-DIMETHYLPHENOL 4-(3-CHLORO-PHENOXY)-BUTYRIC ACID 2'-CHLORO-2,2-DIMETHYLBUTYROPHENONE 2',3'-DICHLORO-2,2-DIMETHYLBUTYROPHENONE 2-PENTYL-1-INDANONE 1-(3-chloro-4-ethoxyphenyl)ethanone DCPIB 1-(3-CHLORO-4-PROPOXYPHENYL)-ETHANONE 3'-CHLORO-2,2-DIMETHYLBUTYROPHENONE 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE 2',3'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE 2,2-DIMETHYL-4'-METHOXYBUTYROPHENONE 4-(4-ACETYL-PHENOXY)-BUTYRIC ACID 1-(4-methoxyphenyl)-2,2-dimethyl-propan-1-one 3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE

  • DCPIB
  • 4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID
  • 4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID
  • Butanoic acid, 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-
  • Cl-Channels,Chloride Channel,cardiomyocytes,DCPIB,ischemia,COS-7,KcsA,Potassium Channel,CPAE cell,Inhibitor,inhibit,swelling,rMCAO
  • 4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid
  • 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-5-indanyl)oxy]butanoic Acid
  • 4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid
  • 82749-70-0
  • Chloride channel