DCPIB
- Product Name
- DCPIB
- CAS No.
- 82749-70-0
- Chemical Name
- DCPIB
- Synonyms
- DCPIB;4-(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYLINDAN-1-ON-5-YL)OXYBUTYRIC ACID;4-(2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl) oxybutyric acid;4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-5-indanyl)oxy]butanoic Acid;4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid;4-[(2-BUTYL-6,7-DICHLORO-2-CYCLOPENTYL-2,3-DIHYDRO-1-OXO-1H-INDEN-5-YL)OXY]BUTANOIC ACID;Butanoic acid, 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-;Cl-Channels,Chloride Channel,cardiomyocytes,DCPIB,ischemia,COS-7,KcsA,Potassium Channel,CPAE cell,Inhibitor,inhibit,swelling,rMCAO
- CBNumber
- CB9215009
- Molecular Formula
- C22H28Cl2O4
- Formula Weight
- 427.36
- MOL File
- 82749-70-0.mol
DCPIB Property
- Boiling point:
- 593.8±50.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO
- form
- solid
- pka
- 4.53±0.10(Predicted)
- color
- White
Safety
- Hazard Codes
- T
- Risk Statements
- 25-41
- Safety Statements
- 26-36/39-45
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1540
- Product name
- DCPIB
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $675
- Updated
- 2021/12/16
- Product number
- 1540
- Product name
- DCPIB
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $160
- Updated
- 2021/12/16
- Product number
- D195150
- Product name
- DCPIB
- Packaging
- 100mg
- Price
- $1105
- Updated
- 2021/12/16
- Product number
- 255115
- Product name
- DCPIB
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- CS-0027766
- Product name
- DCPIB
- Purity
- 99.81%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
DCPIB Chemical Properties,Usage,Production
Uses
DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.
Definition
ChEBI: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid is a member of indanones.
Biological Activity
Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .
storage
Store at +4°C
DCPIB Preparation Products And Raw materials
Raw materials
Preparation Products
DCPIB Suppliers
- Tel
- --
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91