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Acetylcholine chloride

Product Name
Acetylcholine chloride
CAS No.
60-31-1
Chemical Name
Acetylcholine chloride
Synonyms
ACH;ovisot;tl1505;miochol;acecholin;ACECOLINE;achchloride;arterocoline;ARTEROCHOLINE;Acetylcholine chlori
CBNumber
CB9216208
Molecular Formula
C7H16ClNO2
Formula Weight
181.66
MOL File
60-31-1.mol
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Acetylcholine chloride Property

Melting point:
146-150 °C (lit.)
Density 
1.1235 (rough estimate)
refractive index 
1.5560 (estimate)
storage temp. 
room temp
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
White
biological source
synthetic
Water Solubility 
Soluble IN COLD WATER
Sensitive 
Hygroscopic
Merck 
14,87
BRN 
3571875
Stability:
Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.
LogP
-3.904 (est)
CAS DataBase Reference
60-31-1(CAS DataBase Reference)
EPA Substance Registry System
Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (60-31-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
2
RTECS 
FZ9800000
F 
3-8-10-21
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29379000
Toxicity
LD50 in mice, rats (mg/kg): 20, 22 i.v., 170, 250 s.c., 3000, 2500 i.p. (Molitor)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9101
Product name
Acetylcholine chloride
Purity
pkg of 150?mg (per vial)
Packaging
10vials
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
A2661
Product name
Acetylcholine chloride
Purity
suitable for cell culture
Packaging
25g
Price
$77.4
Updated
2024/03/01
Sigma-Aldrich
Product number
1008501
Product name
Acetylcholine chloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
RDD043
Product name
Acetylcholine chloride
Purity
≥99% (TLC), free-flowing, Redi-Dri?
Packaging
100G
Price
$249
Updated
2023/06/20
TCI Chemical
Product number
A0084
Product name
Acetylcholine Chloride
Purity
>98.0%(T)
Packaging
25g
Price
$50
Updated
2024/03/01
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Acetylcholine chloride Chemical Properties,Usage,Production

Description

Acetylcholine is a neurotransmitter that binds to nicotinic and muscarinic acetylcholine receptors (AChRs) in the central and peripheral nervous systems. It mediates motor function at the neuromuscular junction but also has functions in the parasympathetic and sympathetic nervous systems. It is involved in learning and memory through actions at nicotinic AChRs in the CNS. The actions of acetylcholine are terminated primarily via the action of acetylcholinesterase, which breaks it down into acetate and choline. Acetylcholine (chloride) mimics the effects of acetylcholine and has been used to determine the function of acetylcholine in various biological processes. Acetylcholine (chloride) inhibits peptide aggregation of p53 mutants in vitro at micromolar concentrations. It increases alveolar fluid clearance in a dose-dependent manner and enhances Na+/K+-ATPase activity, effects which are blocked by atropine , in a mouse model of pulmonary edema.

Chemical Properties

A white or almost white crystalline powder, or colorless crystals, highly hygroscopic, with a faint ammoniacal odor and a very salty taste. Melting point: 149-152°C. The pH of a 10% aqueous solution is approximately 5, and the substance rapidly decomposes in hot water and alkaline solutions. It is highly soluble in water, ethanol, and propylene glycol; soluble in chloroform and acetic acid; and insoluble in ether. The product exhibits low toxicity, with an LD50 (oral, rat) of 2500 mg/kg.

Uses

Acetylcholine Chloride is a cholinergic, antiarrhythmic, miotic, vasodilator (peripheral).

Application

Acetylcholine Chloride is a cholinergic neurotransmitter that can induce the opening of calcium channels and endogenous neurotransmitter at cholinergic synapses; amplifies sarcolemma action potential inducing muscle contractions.

Preparation

Acetylcholine chloride is synthesized by reacting chloroethanol and trimethylamine aqueous solution, followed by acylation with acetic anhydride.

Definition

ChEBI: Acetylcholine chloride is the chloride salt of acetylcholine, and a parasympatomimetic drug. It contains an acetylcholine.

brand name

Miochol (Novartis).

General Description

Acetylcholine chloride exerts a powerfulstimulant effect on the parasympathetic nervous system.Attempts have been made to use it as a cholinergic agent,but its duration of action is too short for sustained effects,because of rapid hydrolysis by esterases and lack of specificitywhen administered for systemic effects. It is a cardiacdepressant and an effective vasodilator. Stimulation of thevagus and the parasympathetic nervous system produces atonic action on smooth muscle and induces a flow from thesalivary and lacrimal glands. Its cardiac-depressant effectresults from (a) a negative chronotropic effect that causes adecrease in heart rate and (b) a negative inotropic action onheart muscle that produces a decrease in the force of myocardialcontractions.

Biological Activity

Endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Clinical Use

Atropine blocks the depressant effect of ACh on cardiacmuscle and its production of peripheral vasodilation (i.e.,muscarinic effects) but does not affect the skeletal musclecontraction (i.e., nicotinic effect) produced.ACh chloride is a hygroscopic powder that is available inan admixture with mannitol to be dissolved in sterile waterfor injection shortly before use. It is a short-acting mioticwhen introduced into the anterior chamber of the eye and isespecially useful after cataract surgery during the placementof sutures. When applied topically to the eye, it has littletherapeutic value because of poor corneal penetration andrapid hydrolysis by AChE.

Safety Profile

Poison by subcutaneous, intravenous, and parenteral routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. A cholinergic agent. See also CHOLINE ACETATE (ESTER).

storage

Desiccate at RT

Purification Methods

It is very soluble in H2O (>10%), and is very hygroscopic. If pasty, dry it in a vacuum desiccator over H2SO4 until a solid residue is obtained. Dissolve this in absolute EtOH, filter it and add dry Et2O, when the hydrochloride separates. Collect by filtration and store it under very dry conditions. [Jones & Major J Am Chem Soc 52 307 1930.] The chloroplatinate crystallises from hot H2O in yellow needles and can be recrystallised from 50% EtOH, m 242-244o [Dudley Biochem J 23 1069 1929]; other m given is 256-257o. The perchlorate crystallises from EtOH as prisms m 116-117o. [J Am Pharm Assocn 36 272 1947, Beilstein 4 IV 1446.]

Acetylcholine chloride Preparation Products And Raw materials

Raw materials

Erythromycin Estolate Ethanol Acetyl chloride 2-Chloroethanol Trimethylamine

Preparation Products

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View Lastest Price from Acetylcholine chloride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Acetylcholine chloride 60-31-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
Acetylcholine chloride 60-31-1
Price
US $60.00-15.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-25
Weijer International Trade (Hebei) Co., Ltd
Product
Acetylcholine chloride 60-31-1
Price
US $1.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
5000T
Release date
2023-03-15

60-31-1, Acetylcholine chlorideRelated Search:

Sodium triacetoxyborohydride Sulfuryl chloride Bethanechol Polyvinyl chloride Sodium chloride Potassium chloride Acetyl chloride Ammonium chloride Acetoxyacetic acid Calcium chloride Choline chloride Ferric chloride Methyltrimethoxysilane ACETYLCHOLINE BROMIDE DIMETHYLPHOSPHINOTHIOIC CHLORIDE Acetylcholine Silicon tetraacetate Dimethyldimethoxysilane

  • (2-Hydroxyethyl)trimethylammoniumchlorideacetate
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