QUINAZOLINE, 2,4-DICHLORO-6-NITRO
- Product Name
- QUINAZOLINE, 2,4-DICHLORO-6-NITRO
- CAS No.
- 74173-77-6
- Chemical Name
- QUINAZOLINE, 2,4-DICHLORO-6-NITRO
- Synonyms
- 2,4-Dichloro-6-Nitro Quinazoline;QUINAZOLINE, 2,4-DICHLORO-6-NITRO
- CBNumber
- CB9217942
- Molecular Formula
- C8H3Cl2N3O2
- Formula Weight
- 244.03
- MOL File
- 74173-77-6.mol
QUINAZOLINE, 2,4-DICHLORO-6-NITRO Property
- Boiling point:
- 366℃
- Density
- 1.674
- Flash point:
- 175℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.81±0.30(Predicted)
- Appearance
- Light yellow to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD143610
- Product name
- 2,4-Dichloro-6-nitroquinazoline
- Packaging
- 100mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 099092
- Product name
- 2,4-Dichloro-6-nitroquinazoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $435
- Updated
- 2021/12/16
- Product number
- Z5090
- Product name
- 2,4-Dichloro-6-nitroquinazoline
- Packaging
- 1g
- Price
- $465
- Updated
- 2021/12/16
- Product number
- HCH0324492
- Product name
- 2,4-DICHLORO-6-NITRO QUINAZOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.92
- Updated
- 2021/12/16
- Product number
- 35796
- Product name
- 2,4-Dichloro-6-nitroquinazoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $532
- Updated
- 2021/12/16
QUINAZOLINE, 2,4-DICHLORO-6-NITRO Chemical Properties,Usage,Production
Synthesis
32618-85-2
74173-77-6
General procedure for the synthesis of 2,4-dichloro-6-nitroquinazoline from 2,4-dihydroxy-6-nitroquinazoline: To a solution of 6-nitroquinazoline-2,4(1H,3H)-dione (34 g, 164.14 mmol) in trichlorophosphorus (POCl3, 150 mL) was added N,N-dimethylaniline (60 g, 492.42 mmol). The reaction mixture was stirred at 110 °C for 5 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the remaining residue was neutralized with aqueous sodium bicarbonate. The aqueous phase was extracted with ethyl acetate (EtOAc, 80 mL x 3). The organic phases were combined, concentrated to dryness and the residue was purified by silica gel column chromatography (eluent: dichloromethane/petroleum ether = 2:1) to afford 2,4-dichloro-6-nitroquinazoline (5 g, yield: 13%) as a yellow solid.
References
[1] Patent: US2010/204226, 2010, A1. Location in patent: Page/Page column 61
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 9, p. 2797 - 2807
[3] Patent: CN102250075, 2016, B. Location in patent: Paragraph 0395; 0414; 0415
[4] Patent: WO2018/114700, 2018, A1. Location in patent: Page/Page column 22; 53
[5] Patent: WO2015/200534, A2. Location in patent: Paragraph 00414
QUINAZOLINE, 2,4-DICHLORO-6-NITRO Preparation Products And Raw materials
Raw materials
Preparation Products
QUINAZOLINE, 2,4-DICHLORO-6-NITRO Suppliers
- Tel
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- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- enquiry@leancare.co.uk
- Country
- United Kingdom
- ProdList
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- Advantage
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- Tel
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- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from QUINAZOLINE, 2,4-DICHLORO-6-NITRO manufacturers
- Product
- 2,4-Dichloro-6-nitroquinazoline 74173-77-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09
- Product
- 2,4-Dichloro-6-nitroquinazoline 74173-77-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09