3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE

Product Name: 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE
CAS No.: 405911-09-3
Chemical Name: 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE
Synonyms: GW3965;CS-1391;GW3965 (GW 3965;GW 3965 HYDROCHLORIDE;2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic a;2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic acid;Benzeneacetic acid,3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-;3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-diphenylethyl)aMino]propvloxy]phenylacetic acid hydrochloride;3-[3-[[[2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL](2,2-DIPHENYLETHYL)AMINO]PROPOXY]BENZENEACETIC ACID HYDROCHLORIDE
CBNumber: CB9217997
Molecular Formula: C33H31ClF3NO3
Formula Weight: 582.05
MOL File: 405911-09-3.mol

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3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Property

Melting point:: 174-179°C
Boiling point:: 672.4±55.0 °C(Predicted)
Density: 1.261±0.06 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.18±0.10(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 2474
Product name: GW3965 hydrochloride
Purity: ≥98%(HPLC)
Packaging: 1
Price: $131
Updated: 2021/12/16

Tocris

Product number: 2474
Product name: GW3965 hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $280
Updated: 2021/12/16

TRC

Product number: G931050
Product name: GW3965
Packaging: 50mg
Price: $470
Updated: 2021/12/16

ApexBio Technology

Product number: A3454
Product name: GW3965
Packaging: 5mg
Price: $69
Updated: 2021/12/16

ApexBio Technology

Product number: A3454
Product name: GW3965
Packaging: 10mg
Price: $105
Updated: 2021/12/16

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3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

GW3965 can be used in biological study of effect of liver X receptor agonists, T0901317 and GW3965 treatment on cholesterol efflux and apoptosis in human CAL-1 and GEN2.2 blastic plasmacytoid dendritic cell neoplasm cells.

Definition

ChEBI: GW 3965 is a diarylmethane.

Biological Activity

Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR α and hLXR β (EC 50 values are 190 and 30 nM respectively). Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.

target

LXRα

3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Suppliers

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405911-09-3, 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDERelated Search:

3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE

GW3965

GW 3965 HYDROCHLORIDE

3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE

3-[3-[[[2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL](2,2-DIPHENYLETHYL)AMINO]PROPOXY]BENZENEACETIC ACID HYDROCHLORIDE

3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-diphenylethyl)aMino]propvloxy]phenylacetic acid hydrochloride

2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic a

2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic acid

Benzeneacetic acid,3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-

CS-1391

GW3965 (GW 3965

405911-09-3

C33H31ClF3NO3HCl

C33H31NO3ClF3HCl

C33H31ClF3NO3

C33H32Cl2F3NO3

Inhibitor