ChemicalBook > CAS DataBase List > Hygromycin B

Hygromycin B

Product Name
Hygromycin B
CAS No.
31282-04-9
Chemical Name
Hygromycin B
Synonyms
HYGROMYCIN B HYDRATE;950U/MG;Hygromix;Hygrovetin;hygromix-8;hygrovetine;hygromix2.4;hydromycinb;antihelmycin;Hygromycin B
CBNumber
CB9219683
Molecular Formula
C20H37N3O13
Formula Weight
527.52
MOL File
31282-04-9.mol
More
Less

Hygromycin B Property

Melting point:
160-180°C
alpha 
D20 +20.2° (c = 1 in water)
Boiling point:
608.13°C (rough estimate)
Density 
1.4252 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
form 
powder
pka
7.1, 8.8(at 25℃)
color 
faintly brown to brown
PH
pH (25g/l, 25℃ ) : 9.5～12.5
Water Solubility 
Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
Merck 
14,4852
BRN 
6755837
Stability:
Hygroscopic
EPA Substance Registry System
Hygromycin B (31282-04-9)
More
Less

Safety

Hazard Codes 
T+,Xn,T
Risk Statements 
26/27/28-41-42/43-40-36-23/24/25
Safety Statements 
23-26-28-36/37/39-45-22-36-36/37
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
WK2130000
F 
19
HazardClass 
6.1
PackingGroup 
I
HS Code 
29419059
Toxicity
mmo-esc 250 mg/L AACHAX 18,798,80
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
10843555001
Product name
Hygromycin B
Purity
from Streptomyces hygroscopicus
Packaging
20ml
Price
$312
Updated
2024/03/01
Sigma-Aldrich
Product number
400050
Product name
Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem
Purity
Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells.
Packaging
1G
Price
$348
Updated
2022/05/15
Sigma-Aldrich
Product number
400050
Product name
Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem
Purity
Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells.
Packaging
5G
Price
$1290
Updated
2022/05/15
TCI Chemical
Product number
H1509
Product name
Hygromycin B
Purity
>80.0%(HPLC)
Packaging
200mg
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
H1509
Product name
Hygromycin B
Purity
>80.0%(HPLC)
Packaging
1g
Price
$176
Updated
2024/03/01
More
Less

Hygromycin B Chemical Properties,Usage,Production

Description

Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.

Chemical Properties

White to off-white lyophilized powder

Uses

antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg

Uses

Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome

Uses

Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome

Uses

Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.

Application

Hygromycin B was found in the culture broth of Streptomyces hygroscopicus by Lilly Research Laboratories in 1953, as a mixture with hygromycin A. It showed activity against a variety of gram-positive and gram-negative bacteria as well as fungi. Hygromycin B has been used for therapy of helminthic infections in swine and poultry.

General Description

Amorphous solid or tan powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Weakly basic.

Fire Hazard

Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.

Biochem/physiol Actions

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation. Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Safety Profile

Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

storage

+4°C

References

[1] brodersen de, clemons wm jr, carter ap, et al. the structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin b on the 30s ribosomal subunit. cell, 2000, 103 (7): 1143-1154.
[2] ganoza mc, kiel mc. a ribosomal atpase is a target for hygromycin b inhibition on escherichia coli ribosomes. antimicrob agents chemother, 2001, 45 (10): 2813-2819.

Hygromycin B Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Hygromycin B Suppliers

Americas 1 Australia 1 Canada 4 China 262 Europe 4 France 1 Germany 11 India 12 Japan 4 Poland 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 16 United States 48 Global 370
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
American Bioanalytical, Inc.
Tel
--
Fax
--
Country
United States
ProdList
19
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Genegobio Inc.
Tel
--
Fax
--
Email
mark@genegobio.com
Country
United States
ProdList
195
Advantage
0
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
AmericanBIO, Inc.
Tel
--
Fax
--
Email
Heidi.Fleshman@americanbio.com
Country
United States
ProdList
52
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Wonda Science
Tel
--
Fax
--
Email
wonda@wondascience.com
Country
United States
ProdList
2192
Advantage
50
TOKU-E Company
Tel
--
Fax
--
Email
info@toku-e.com
Country
United States
ProdList
320
Advantage
50
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
PhytoTechnology Laboratories
Tel
--
Fax
--
Email
cs@phytotechlab.com
Country
United States
ProdList
143
Advantage
71
www.vwrsp.com
Tel
--
Fax
--
Email
B2B@VWR.com
Country
United States
ProdList
622
Advantage
86
Onbio Inc.
Tel
--
Fax
--
Email
info@onbio.net
Country
United States
ProdList
172
Advantage
58
Kainic.com
Tel
--
Fax
--
Email
info@Kainic.com
Country
United States
ProdList
330
Advantage
38
American Bioanalytical
Tel
--
Fax
--
Email
wenli@smith.edu
Country
United States
ProdList
167
Advantage
69
EMD Chemicals Inc.
Tel
--
Fax
--
Email
emdinfo@emdchemicals.com
Country
United States
ProdList
1525
Advantage
77
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
CLONTECH Laboratories, Inc.
Tel
--
Fax
--
Email
orders@clontech.com
Country
United States
ProdList
834
Advantage
85
AMRESCO Inc.
Tel
--
Fax
--
Email
info@amresco-inc.com
Country
United States
ProdList
760
Advantage
73
Roche Applied Science
Tel
--
Fax
--
Email
biochemts.us@roche.com
Country
United States
ProdList
696
Advantage
85
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
novatech@novagen.com
Country
United States
ProdList
609
Advantage
77
Stratagene
Tel
--
Fax
--
Email
help@stratagene.com
Country
United States
ProdList
1139
Advantage
81
A.G. Scientific, Inc.
Tel
--
Fax
--
Email
support@agscientific.com
Country
United States
ProdList
1066
Advantage
71
More
Less

View Lastest Price from Hygromycin B manufacturers

Apeloa production Co.,Limited
Product
Hygromycin B 31282-04-9
Price
US $1.00/g
Min. Order
1g
Purity
0.98
Supply Ability
1000
Release date
2024-05-29
Shanghai Affida new material science and technology center
Product
Hygromycin B 31282-04-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99
Supply Ability
50000KG/month
Release date
2024-04-24
Henan Fengda Chemical Co., Ltd
Product
Hygromycin B 31282-04-9
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

31282-04-9, Hygromycin BRelated Search:

ALTRENOGEST Tetracycline hydrochloride hygromycin A Butyl stearate Bromothymol Blue Maduramicin Tilmicosin phosphate Betaine Glycerol Glycine FEMA 2542 Triethyl orthobutyrate 2-METHOXY-1,3-DIOXOLANE Trimethyl orthobutyrate Triethyl orthopropionate AMINO ACIDS Hygromycin B

  • antihelmycin
  • hydromycinb
  • hygromix2.4
  • hygromix-8
  • hygrovetine
  • Hygromycin Solution
  • Hygromix
  • 5-O-(2,3-O-(6-Amino-6-desoxyheptapyranosyliden)-beta-D-talopyranosyl)-desoxy-N'-methyl-D-streptamin
  • Hygrovetin
  • O-6-Amino-6-deoxy-
  • Hygromycin B
  • Hygromycin B, powder
  • Hygromycin B, PBS solution
  • HygroMycin B, OMniPur(R)
  • hygromycin B aqueous solution
  • hygromycin B from streptomyces*hygroscopicus
  • hygromycin B plant cell culture tested
  • hygromycin B solution from streptomyces hygroscopicus
  • Hygromycin B solution Streptomyces hygroscopicus
  • HYGROMYCIN B FROM STREPTOMYCES*HYGROSCOP ICUS LYOPHI
  • HYGROMYCIN B FROM STREPTOMYCES*HYGROSCOP ICUS, CELL
  • Hygromycin B <FN>from Streptomyces hygroscopicus</FN> from Streptomyces hygrosco
  • HYGROMYCIN B 85+%
  • HYGROMYCIN B 98+%
  • HygromycinB,Streptomyceshygroscopicus,HighPurity,inDIWater
  • HygromycinB,HighPurity,Solid,CellCultureTested
  • HygromycinB,Streptomyceshygroscopicus,ConcentratedSolution
  • HygromycinB,Streptomyceshygroscopicus,HighPurity,inPBSBuffer
  • D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1?2-3)-O-.beta.-D-talopyranosyl-(1?5)-2-deoxy-N3-methyl-
  • Hyaromycin B
  • HYGROMYCIN B, HIGH PURITY, POWDER, CELL CULTURE TESTED
  • HYGROMYCIN B, HIGH PURITY, IN HEPES BUFFER, CELL CULTURE TESTED
  • HYGROMYCIN B, HIGH PURITY, IN DI WATER, CELL CULTURE TESTED
  • HYGROMYCIN B, HIGH PURITY, IN PBS BUFFER, CELL CULTURE TESTED
  • O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
  • 950U/MG
  • D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N3-methyl-
  • Hygromycin B O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine
  • Hygromycin B Solution, 100ppm
  • HYGROMYCIN B--100 mg/mL WATER
  • HYGROMYCIN B--1000 UNIT POWDER
  • HYGROMYCIN B--50 mg/mL PBS
  • Hygromycin B, 80%, from Streptomyces hygroscopicus
  • Hygromycin B, Streptomyces sp. - CAS 31282-04-9 - Calbiochem
  • Hygromycin B, Streptomyces sp., Cell Culture-Tested - CAS 31282-04-9 - Calbiochem
  • Hygromycin B, Streptomyces sp., Sterile-Filtered Solution in 25 mM HEPES, Cell Culture-Tested - CAS 31282-04-9 - Calbiochem
  • Hygromycin B solution,1000ppm
  • Hygromycin B from Streptomyces hygroscopicus Vetec(TM) reagent grade
  • UREA 8M SOLUTION PROTEOMICS GRADE
  • Hygromycin B fromStreptomyces hygroscopicus≥ 90% (HPLC)
  • Hygromycin B solution from Biological Fermentation
  • HYGROMYCIN B HYDRATE
  • HYGROMYCIN B, STREPTOMYCES HYGROSCOPICUS
  • HYGROMYCIN B, STREPTOMYCES SPECIES
  • HYGROGOLD(TM)
  • O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTOHEPTAPYRANOSYLIDENE-(1,2,3)-O-BETA-D-TALOPYRANOSYL-(1,5)-2-DEOXY-N3-METHYL-D-STREPTAMINE
  • o-6-amino-6-deoxy-l-glycero-d-galacto-heptopyranosylidene-(1-2-3)-o-beta-d-talopyranosyl-(1-5)-2-deoxy-n3-methyl-d-streptamine
  • O-6-AMINO-6-DEOXY-L-GLYCERO-D-GALACTO-HEPTOPYRANOSYLIDENE-(1-2-3)-O-BETA-D-TALOPYRANOSYL(1-5)-2-DEOXY-N3-METHYL-D-STREPTAMINE