3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID

Product Name: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
CAS No.: 195457-70-6
Chemical Name: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
Synonyms: AKOS BAR-0024;RARECHEM AL BE 1367;4-[3-(trifluoromethyl)phenyl]benzoate;4-(3-(Trifluoromethyl)phenyl)benzoic acid;3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID;3'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL-4-CARBOXYLIC ACID;3'-(Trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid;[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-(TRIFLUOROMETHYL)-;3′-(Trifluoromethyl)-[1,1′-biphenyl]-4-carboxylic acid, CAS 195457-70-6
CBNumber: CB9228078
Molecular Formula: C14H9F3O2
Formula Weight: 266.22
MOL File: 195457-70-6.mol

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3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Property

storage temp.: Sealed in dry,Room Temperature
form: solid
color: Yellow
CAS DataBase Reference: 195457-70-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T779085
Product name: 4-(3-Trifluoromethylphenyl)benzoicAcid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T779085
Product name: 4-(3-Trifluoromethylphenyl)benzoicAcid
Packaging: 1g
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 119637
Product name: 3'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $198
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2821-3-X2
Product name: 3'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
Packaging: 5G
Price: $352
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2821-3-X2
Product name: 3'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
Packaging: 250mg
Price: $40
Updated: 2021/12/16

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3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

4-(3-Trifluoromethylphenyl)benzoic Acid is a reagent used in the synthesis of aryl-substituted aspartic acid and diaminopropionic acid derivatives as inhibitors of glutamate transporter EAAT-2 (Excitatory amino acid transporters 2).

Synthesis

586-76-5

1423-26-3

195457-70-6

The general procedure for the synthesis of 4-(3-trifluoromethylphenyl)benzoic acid from 4-bromobenzoic acid and 3-(trifluoromethyl)phenylboronic acid was as follows: Pd(dppf)Cl2 (1.49 mmol, 1.09 g) was added to a mixture containing 4-bromobenzoic acid (14.9 mmol, 3.0 g), 3-(trifluoromethyl)phenylboronic acid (17.9 mmol, 3.4 g), and Cs2CO3 (37.3 mmol, 12.2 g) in a suspension with the solvent being a mixture of 30 mL dioxane and 7.5 mL ethanol. The reaction mixture was stirred at 80 °C for 2 hours. After completion of the reaction, it was cooled to room temperature, the solid product was collected by filtration and washed with methanol. The filtrate was concentrated and the residue was partitioned between ethyl acetate and 1N aqueous hydrochloric acid. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. To the concentrated residue was added dichloromethane, the resulting solid was collected by filtration, washed with dichloromethane and dried to give 4-(3-trifluoromethylphenyl)benzoic acid (3.58 g, 86% yield), which could be used in the next reaction without further purification.

References

[1] Patent: US2013/102584, 2013, A1. Location in patent: Paragraph 0307; 0308
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3144 - 3150

3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

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3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID Suppliers

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View Lastest Price from 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 195457-70-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-26

195457-70-6, 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACIDRelated Search:

3-(TRIFLUOROMETHYL)BIPHENYL 3'-TRIFLUOROMETHYLBIPHENYL-3-CARBOXYLIC ACID 2'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID,Trifluoromethylbiphenyl-4-carboxylic acid 4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 4'-FLUORO-3'-TRIFLUOROMETHYL-BIPHENYL-4-CARBOXYLIC ACID 3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID RARECHEM AL BI 1367 AKOS BAR-2150 3',5'-DI-(TRIFLUOROMETHYL)-BIPHENYL-4-CARBOXYLIC ACID 3-fluoro-3'-(trifluoromethyl)-1,1'-biphenyl-4-carboxylic acid METHYL 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLATE AKOS BAR-2112 AKOS BAR-2103 METHYL 4'-NITRO-3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLATE

3'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID

3'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL-4-CARBOXYLIC ACID

AKOS BAR-0024

[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 3'-(TRIFLUOROMETHYL)-

RARECHEM AL BE 1367

4-(3-(Trifluoromethyl)phenyl)benzoic acid

4-[3-(trifluoromethyl)phenyl]benzoate

3'-(Trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid

3′-(Trifluoromethyl)-[1,1′-biphenyl]-4-carboxylic acid, CAS 195457-70-6

195457-70-6

pharmacetical