ChemicalBook > CAS DataBase List > Sodium gluconate

Sodium gluconate

Product Name
Sodium gluconate
CAS No.
527-07-1
Chemical Name
Sodium gluconate
Synonyms
GLUCONIC ACID SODIUM SALT;glonsen;Natriumgluconat;SODIUM D-GLUCONATE;Gluconic Acid Sodium;SODIUM GLUCONATE REAGENT;sodium pentahydyoxycaproate;pasexon100t;BVD Addicrete;Sunmorl N 60S
CBNumber
CB9229989
Molecular Formula
C6H13NaO7
Formula Weight
220.15
MOL File
527-07-1.mol
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Sodium gluconate Property

Melting point:
170-175 °C
alpha 
[α]D20 +11～+13° (c=10, H2O)
storage temp. 
Store below +30°C.
solubility 
H2O: 0.1 g/mL, clear
form 
Crystalline Powder
color 
White to light beige
PH
7.0-8.0 (100g/l, H2O, 20℃)
Odor
wh. to ylsh. cryst. powd., pleasant odor
Water Solubility 
Very soluble in water; sparingly soluble in alcohol; insoluble in ether.
Merck 
14,4456
BRN 
3919651
Stability:
Stable. Incompatible with strong oxidizing agents.
InChI
InChI=1/C6H12O7.Na.H/c7-1-2(8)3(9)4(10)5(11)6(12)13;;/h2-5,7-11H,1H2,(H,12,13);;/t2-,3-,4+,5-;;/s3
InChIKey
MPPJUDJABRMYJR-QZHCVFHNNA-N
SMILES
[C@@H](O)([C@@H](O)C(=O)O)[C@H](O)[C@H](O)CO.[NaH] |&1:0,2,7,9,r|
LogP
-3.175 (est)
CAS DataBase Reference
527-07-1(CAS DataBase Reference)
EPA Substance Registry System
Sodium gluconate (527-07-1)
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Safety

Safety Statements 
24/25
WGK Germany 
1
RTECS 
LZ5235000
Autoignition Temperature
>200 °C
TSCA 
Yes
HS Code 
29181600
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22058
Product name
Gluconic acid sodium salt
Purity
for synthesis
Packaging
100g
Price
$27.4
Updated
2024/03/01
Sigma-Aldrich
Product number
G9005
Product name
D-Gluconic acid sodium salt
Purity
≥99%
Packaging
1kg
Price
$59.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22058
Product name
Gluconic acid sodium salt
Purity
for synthesis
Packaging
1kg
Price
$36.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22058
Product name
Gluconic acid sodium salt
Purity
for synthesis
Packaging
2.5kg
Price
$66.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22058
Product name
Gluconic acid sodium salt
Purity
for synthesis
Packaging
50kg
Price
$803
Updated
2024/03/01
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Sodium gluconate Chemical Properties,Usage,Production

Description

Sodium gluconate is the organic sodium salt of gluconic acid. Sodium gluconate is a chelator that forms stable complexes with various ions and ultimately prevents these ions from engaging in chemical reactions. Gluconates are naturally occurring substances that freely dissociate to the gluconate anion and its respective cations. Being fully biodegradable and non-toxic, it represents an environment friendly alternative to the common chelating agents used in cosmetics such as EDTA. In addition to this, sodium gluconate has a low acute toxicity to aquatic organisms.

Chemical Properties

Sodium gluconate is a white to tan, granular to fine, practically odourless crystalline powder. It is very soluble in water, sparingly soluble in alcohol and insoluble in ether.

Originator

JUNGBUNZLAUER INC.

Uses

Sodium gluconate is used as a natural preservative. It prevents the growth of microbes in our products to keep them safe for our consumers. It also works as a skin-conditioning agent and a chelating agent which helps cleansing products to foam better in hard water. You can often find sodium gluconate in soap, sunscreen, shampoo, toothpaste, hair products, makeup, and a variety of other personal care products.
Sodium gluconate has been used as a component of recording buffer used in two-electrode voltage-clamp (TEVC) recording in Xenopus laevis oocytes. It has also been used as a control for sodium.

Definition

ChEBI: Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.

Production Methods

Sodium gluconate is manufactured by the fermentation of carbohydrate containing the raw material glucose syrup derived from maize. After a crystallisation step, sodium gluconate is separated from the mother liquor by centrifugation, the crystals are dried and then sieved to guarantee the desired granulation. Based on the production process as well as the raw materials used, sodium gluconate is not synthetic natural.

Therapeutic Function

Electrolyte replenisher

Biochem/physiol Actions

Ingestion of sodium gluconate is known to stimulate the production of intestinal butyrate. It is widely used in food, pharmaceutical paper and textile industry. It acts as a chelating agent. Sodium gluconate serves as a detergent in bottle washing formulation.

Safety Profile

Low toxicity by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes

Synthesis

The calcium gluconate is added into the reaction kettle. Add sulfuric acid aqueous solution while stirring. After mixing for one hour, let it stand for a while and then get it filtered. The filter residue is CaSO4 and gets it removed. The filtrate is added into the neutralization kettle, and a proper amount of Na2CO3 aqueous solution is added to neutralize it. Finally get sodium gluconate through concentration, filtration and drying.

Purification Methods

Crystallise it from a small volume of H2O (solubility is 59g/100mL at 25o), or dissolve it in H2O and add EtOH since it is sparingly soluble in EtOH. It is insoluble in Et2O. It forms a Cu complex in alkaline solution and a complex with Fe in neutral solution. [cf p 639, Sawyer & Bagger J Am Chem Soc 81 5302 1959, Beilstein 3 I 188.]

Regulations

In Europe, sodium gluconate is listed as a generally permitted food additive (E576) and may be added to all foodstuffs, following the "quantum satis" principle, as long as no special regulation restricts the use.
The US Food and Drug Administration (FDA) assigned sodium gluconate the “generally recognised as safe” (GRAS) status and permitted its use in food without limitation other than current good manufacturing practice.
Sodium gluconate is exempted from the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) by means of Commission Regulation (EC) No. 987/2008 of 8 October, 2008 (amending Annex IV). As a consequence thereof, there is no need to register sodium gluconate.

Sodium gluconate Preparation Products And Raw materials

Raw materials

Calcium gluconate D(+)-Glucose Gluconic acid Sodium hydroxide Sodium carbonate

Preparation Products

Sodium Stibogluconate Calcium gluconate Copper(II) gluconate Zinc gluconate
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Sodium gluconate Suppliers

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View Lastest Price from Sodium gluconate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sodium Gluconate 527-07-1
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-15
Hebei Andu Technology Com.,Ltd
Product
Sodium gluconate 527-07-1
Price
US $3.50/kg
Min. Order
1kg
Purity
≥99%
Supply Ability
3000tons/month
Release date
2024-08-17
Shandong Deshang Chemical Co., Ltd.
Product
Sodium gluconate 527-07-1
Price
US $9.90-7.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-10-15

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