Cefmetazole

Product Name: Cefmetazole
CAS No.: 56796-20-4
Chemical Name: Cefmetazole
Synonyms: cs1170;(6r;CMZ;U 72791;U 72791a;SKF 83088;Cefatrixine;Cefmetazole;Cefmetazolo;Cefmetazolum
CBNumber: CB9231320
Molecular Formula: C15H17N7O5S3
Formula Weight: 471.53
MOL File: 56796-20-4.mol

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Cefmetazole Property

Melting point:: 163-165?C
Density: 1.4380 (rough estimate)
refractive index: 1.7400 (estimate)
storage temp.: 2-8°C
solubility: Methanol (Slightly, Heated)
pka: 2.65±0.50(Predicted)
form: Solid
color: White
Water Solubility: Soluble in water
CAS DataBase Reference: 56796-20-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 26-36
WGK Germany: 2
RTECS: XI0372200
HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1097782
Product name: Cefmetazole
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200MG
Price: $420
Updated: 2024/03/01

Alfa Aesar

Product number: J66791
Product name: Cefmetazole
Packaging: 5g
Price: $406
Updated: 2024/03/01

Alfa Aesar

Product number: J66791
Product name: Cefmetazole
Packaging: 1g
Price: $89.1
Updated: 2021/12/16

Cayman Chemical

Product number: 30269
Product name: Cefmetazole
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 30269
Product name: Cefmetazole
Packaging: 100mg
Price: $961
Updated: 2024/03/01

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Cefmetazole Chemical Properties,Usage,Production

Description

Cefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged clotting times.

General Description

Cefmetazole was synthesized by Sankyo Co. in 1976starting with a biosynthetic cephamycin. It shows excellent activity against Serratia and Proteus, against which cefazolin is not active, and it has stronger activity than cefoxitin, another derivative of cephamycin. Cefmetazole is active against anaerobes and resistant to β-lactamase, but it is not active against Pseudomonas aeruginosa.

Chemical Properties

White Solid

Uses

Semi-synthetic antibiotic derived from Cephamycin. Antibacterial.

Uses

A broad spectrum second generation cephalosporin antibiotic

Definition

ChEBI: A cephalosporin antibiotic containg an N1-methyltetrazol-5-ylthiomethyl side-chain at C-3 of the parent cephem bicyclic structure.

Antimicrobial activity

It is active against Pr. mirabilis, Pr. vulgaris, Morganella morganii, Yersinia spp.and most anaerobes. S. marcescens is moderately susceptible, but Ps. aeruginosa and E. faecalis are resistant. It is active against Mycobacterium fortuitum and some strains of M. chelonei. It is resistant to a wide range of β-lactamases.
The serum concentration at the end of a 1 g intravenous infusion is around 77 mg/L. Plasma protein binding is 68%. It is principally excreted in the urine with a plasma half-life of c. 1.3 h; 70% is recovered over the first 6 h. In patients whose creatinine clearance is less than 10 mL/min, plasma levels are elevated and the plasma half-life is increased to around 15 h.
Side effects associated with the methylthiotetrazole group at position C-3 have been reported. Uses are similar to those of cefoxitin, but it is not widely available.

Cefmetazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Cefmetazole Suppliers

Belgium 1 Canada 2 China 113 Germany 2 India 4 Switzerland 1 United Kingdom 7 United States 18 Global 148

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View Lastest Price from Cefmetazole manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Cefmetazole 56796-20-4
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: 99%
Supply Ability: 10kg
Release date: 2024-04-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cefmetazole 56796-20-4
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97.5%min
Supply Ability: 100KG
Release date: 2021-06-08

Hebei Mojin Biotechnology Co., Ltd

Product: Cefmetazole 56796-20-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-01

56796-20-4, CefmetazoleRelated Search:

Bensulfuron methyl Methyl acrylate Acetyl coenzyme A sodium salt Kresoxim-methyl Methylparaben Acetaminophen Cefotetan 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium inner salt Cefozopran Ceftiofur sodium Methyl Parathion-methyl CEFMETAZOLE ACID Methyl bromide Cefmetazole-Na,Sodium cefmetazole,Cefmetazole sodium 7-TMCA 3-AZETIDINOL 1-METHYL-3-AZETIDINOL

(6R,7S)-7-[[2-[(CyanoMethyl)thio]acetyl]aMino]-7-Methoxy-3-[[(1-Methyl -1H-tetrazol-5-yl)thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -2-carboxylic Acid

(6r

5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((((cyanomethyl)thio)a

cs1170

Cefmetazole, 97-103%

CEFMETAZOLE SODIUM SALT

Cefmetazole

Cefatrixine

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7S)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R-cis)-

SKF 83088

U 72791

U 72791a

(6R-cis)-7-[[[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R)-7α-[2-(Cyanomethylthio)acetylamino]-7β-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7S)-7-[[[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CMZ

Cefmetazole (200 mg)G0E2600.988mg/mg(ai)

Cefmetazole (200 mg)

Ferrous Sulfate (2 x 1 g)

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7S)-

(6R,7S)-7-(2-((cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefmetazole USP/EP/BP

CEFMETAZOLE ACID 56796-20-4

Cefmetazole (1097782)

Cefmetazolo

Cefmetazolum

(6R,7S)-7-(2-((Cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid (Cefmetazole Impurity)

Cefmetazole, free acid

56796-20-4

C14H15N7O4S3

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