Isoalantolactone

Product Name: Isoalantolactone
CAS No.: 470-17-7
Chemical Name: Isoalantolactone
Synonyms: ISOHELENIN;ISOALANTOACTONE;isocoxiolactone;ISOALANTOLACTONE;(+)-Isoalantolactone;ISOALANTOLACTONE (RG);Isoalantolactone USP/EP/BP;(+)-Isoalantolactone|||Isohelenin;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-
CBNumber: CB9234785
Molecular Formula: C15H20O2
Formula Weight: 232.32
MOL File: 470-17-7.mol

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Isoalantolactone Property

Melting point:: 115℃
Boiling point:: 364.9±42.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI: InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h11-13H,1-2,4-8H2,3H3/t11-,12+,13-,15-/m1/s1
InChIKey: CVUANYCQTOGILD-QVHKTLOISA-N
SMILES: O1C(=O)C(=C)[C@@]2([H])C[C@]3([H])[C@@](C)(C[C@@]12[H])CCCC3=C
LogP: 3.420
CAS DataBase Reference: 470-17-7(CAS DataBase Reference)
NIST Chemistry Reference: Naphtho(2,3-b)furan-2(3h)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3ar-(3a«alpha»,4a«alpha»,8a«beta»,9a«alpha»))-(470-17-7)

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Safety

Hazard Codes: Xn
Risk Statements: 40
Safety Statements: 22-36
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 300468
Product name: Isoalantolactone
Packaging: 20mg
Price: $320
Updated: 2021/12/16

Usbiological

Product number: 280646
Product name: Isoalantolactone
Packaging: 50mg
Price: $333
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FI32778
Product name: Isoalantolactone
Packaging: 50mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-3635
Product name: Isoalantolactone
Purity: 99.99%
Packaging: 10mg
Price: $78
Updated: 2021/12/16

AK Scientific

Product number: Y0110
Product name: Isoalantolactone
Packaging: 10mg
Price: $78
Updated: 2021/12/16

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Isoalantolactone Chemical Properties,Usage,Production

Description

Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 μM)1 acting via inhibition of IKK?6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6

Uses

Isoalantolactone is a sesquiterpene lactone used in the treatment of cancer. It can inhibit tumor cell growth and induce apoptosis.

Definition

ChEBI: A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.

References

Bork et al. (1997), Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NK-kappaB; FEBS Lett., 402 85 Mazor et al. (2000), Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium; Cytokine, 12 239 Wong and Menendez (1999), Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells; Biochem. Biophys. Res. Commun., 262 375 Li et al. (2001), Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NK-kappaB transcription factor; Int. J. Mol. Med., 7 527 Sheehan et al. (2002), Protective effects of isohelenin, an inhibitor of nuclear factor KappaB in endotoxic shock in rats; Endotoxin Res, 8 99 Xing et al. (2019), Isoalantolactone inhibits IKK? kinase activity to interrupt the NF-kB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma; Cancer Med., 8 1655

Isoalantolactone Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoalantolactone Suppliers

China 192 Europe 3 Germany 2 India 1 United Kingdom 5 United States 24 Global 227

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View Lastest Price from Isoalantolactone manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Isoalantolactone 470-17-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-25

Shanghai Standard Technology Co., Ltd.

Product: Isoalantolactone 470-17-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-24

Career Henan Chemical Co

Product: Isoalantolactone 470-17-7
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

470-17-7, IsoalantolactoneRelated Search:

Bensulfuron methyl ε-Caprolactone METHYL THIOPHENE-2-CARBOXYLATE Spironolactone D-(+)-Glucono-1,5-lactone Furan Methyl acrylate Alantolactone Thiophanate-methyl Methylparaben Kresoxim-methyl IsorhaMnetin 3-sophoroside-7-rhaMnoside CNIDILIN ISORHAMNETIN 3-O-NEOHESPEROSIDE (R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one Methyl Methyl bromide (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER

11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone

ISOALANTOACTONE

ISOALANTOLACTONE

ISOHELENIN

(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one

methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-

Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-

(3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one

(3aR,4aα,9aα)-3a,4,4a,5,6,7,8,8a,9,9a-Decahydro-8aβ-methyl-3,5-bis(methylene)naphtho[2,3-b]furan-2(3H)-one

ISOALANTOLACTONE (RG)

Isoalantolactone (3aR,4aS,8aR,9aR)-8a-Methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one

(3AR,4aS,8aR,9aR)-8a-methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one

Isoalantolactone, 98%, from Inula helenium L.

Naphtho[2,3-b]furan-2(3H)-one, decahydro-8a-methyl-3,5-bis(methylene)-, (3aR,4aS,8aR,9aR)-

Isoalantolactone USP/EP/BP

(+)-Isoalantolactone

isocoxiolactone

(+)-Isoalantolactone|||Isohelenin

470-17-7

Inhibitors

Miscellaneous Natural Products

chiral

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract