ChemicalBook > CAS DataBase List > 3,4-BIS(BENZYLOXY)BENZOIC ACID

3,4-BIS(BENZYLOXY)BENZOIC ACID

Product Name: 3,4-BIS(BENZYLOXY)BENZOIC ACID
CAS No.: 1570-05-4
Chemical Name: 3,4-BIS(BENZYLOXY)BENZOIC ACID
Synonyms: RARECHEM AL BE 0665;3,4-BIS(BENZYLOXY)BENZOIC ACID;3,4-Bis(phenylMethoxy)-benzoic Acid;Benzoic acid,3,4-bis(phenylmethoxy)-
CBNumber: CB9234790
Molecular Formula: C21H18O4
Formula Weight: 334.37
MOL File: 1570-05-4.mol

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3,4-BIS(BENZYLOXY)BENZOIC ACID Property

Melting point:: 182 °C
Boiling point:: 512.7±40.0 °C(Predicted)
Density: 1.232±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly, Heated), DMSO (Slightly)
form: Solid
pka: 4.31±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C21H18O4/c22-21(23)18-11-12-19(24-14-16-7-3-1-4-8-16)20(13-18)25-15-17-9-5-2-6-10-17/h1-13H,14-15H2,(H,22,23)
InChIKey: BYOKJLCIKSFPDU-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(OCC2=CC=CC=C2)C(OCC2=CC=CC=C2)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B521350
Product name: 3,4-Bis(phenylmethoxy)-benzoicAcid
Packaging: 25g
Price: $1190
Updated: 2021/12/16

AK Scientific

Product number: D411
Product name: 3,4-Bis(benzyloxy)benzoicacid
Packaging: 10g
Price: $528
Updated: 2021/12/16

Crysdot

Product number: CD12137649
Product name: 3,4-Bis(benzyloxy)benzoicacid
Purity: 97%
Packaging: 25g
Price: $594
Updated: 2021/12/16

AHH

Product number: MT-36858
Product name: 3,4-Bis(benzyloxy)benzoicacid
Purity: 97%
Packaging: 10g
Price: $670
Updated: 2021/12/16

Acrotein

Product number: AC-3438
Product name: 3,4-Bis(benzyloxy)benzoicacid
Purity: 97%
Packaging: 25g
Price: $913
Updated: 2021/12/16

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3,4-BIS(BENZYLOXY)BENZOIC ACID Chemical Properties,Usage,Production

Uses

3,4-Bis(phenylmethoxy)-benzoic Acid is a useful synthetic intermediate. It is an intermediate used to synthesize Jaboticabin (J210370) which is minor bioactive depside potent to treat chronic obstructive pulmonary disease.

Synthesis

54544-05-7

1570-05-4

C) Synthesis of 3,4-dibenzyloxybenzoic acid: Sodium hydroxide (1.2 g) was dissolved in methanol (100 mL) to prepare a methanolic solution of sodium hydroxide. This solution was added to a solution of methanol (50 mL) containing methyl 3,4-dibenzyloxybenzoate (4.64 g), and the reaction mixture was heated under reflux for 4 hours. After completion of the reaction, the methanol was evaporated under reduced pressure. The residue was dissolved in water (100 mL) and the aqueous layer was washed with ethyl acetate (2 x 50 mL). Subsequently, the aqueous layer was acidified to pH 2 with 2N hydrochloric acid, whereupon 3,4-dibenzyloxybenzoic acid precipitated as a precipitate. The precipitate was collected by filtration and dried under vacuum to give 2.4 g of 3,4-dibenzyloxybenzoic acid in 74% yield. The product was characterized by 1H NMR (CDCl3): δ 7.7 (2H, br s), 7.27-7.5 (10H, m), 6.98 (1H, d, J=8 Hz), 5.26 (2H, s), 5.22 (2H, s).

References

[1] Canadian Journal of Chemistry, 2006, vol. 84, # 10, p. 1411 - 1415
[2] Patent: WO2005/113489, 2005, A1. Location in patent: Page/Page column 90
[3] European Journal of Medicinal Chemistry, 1997, vol. 32, # 5, p. 409 - 423
[4] Heterocycles, 2014, vol. 8, # 2, p. 1371 - 1396
[5] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 24 - 33

3,4-BIS(BENZYLOXY)BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4-BIS(BENZYLOXY)BENZOIC ACID manufacturers

Career Henan Chemical Co

Product: 3,4-BIS(BENZYLOXY)BENZOIC ACID 1570-05-4
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-26

1570-05-4, 3,4-BIS(BENZYLOXY)BENZOIC ACIDRelated Search:

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3,4-BIS(BENZYLOXY)BENZOIC ACID

RARECHEM AL BE 0665

3,4-Bis(phenylMethoxy)-benzoic Acid

Benzoic acid,3,4-bis(phenylmethoxy)-

1570-05-4