4-FLUORO-3-METHOXYPHENYLBORONIC ACID

Product Name: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
CAS No.: 854778-31-7
Chemical Name: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
Synonyms: uoro-3-methoxyphenyL;Elagolix Impurity 50;5-Borono-2-fluoroanisole;4-Fluoro-3-Methoxyphenylboronic;4-Fluoro-5-methoxyphenylboronic acid;4-FLUORO-3-METHOXYPHENYLBORONIC ACID;4-FLUORO-3-METHOXYBENZENEBORONIC ACID;4-Fluoro-3-methoxybenzeneboronicacid98%;4-Fluoro-3-methoxybenzeneboronic acid 98%;Boronic acid, B-(4-fluoro-3-methoxyphenyl)-
CBNumber: CB9237771
Molecular Formula: C7H8BFO3
Formula Weight: 169.95
MOL File: 854778-31-7.mol

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4-FLUORO-3-METHOXYPHENYLBORONIC ACID Property

Melting point:: 189-191
Boiling point:: 318.1±52.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 8.19±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C7H8BFO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,10-11H,1H3
InChIKey: LUJMSRVFSBMEOY-UHFFFAOYSA-N
SMILES: B(C1=CC=C(F)C(OC)=C1)(O)O

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0919
Product name: 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: F0919
Product name: 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $167
Updated: 2025/07/31

TRC

Product number: F595678
Product name: 4-Fluoro-3-methoxyphenylboronicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: F595678
Product name: 4-Fluoro-3-methoxyphenylboronicacid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC5053
Product name: 4-Fluoro-3-methoxybenzeneboronic acid
Purity: 98%
Packaging: 250mg
Price: $22
Updated: 2021/12/16

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4-FLUORO-3-METHOXYPHENYLBORONIC ACID Chemical Properties,Usage,Production

Uses

suzuki reaction

Synthesis

103291-07-2

854778-31-7

General procedure for the synthesis of 4-fluoro-3-methoxyphenylboronic acid from 2-fluoro-5-bromoanisole: To a solution of 2-fluoro-5-bromoanisole (2.7 g, 13.1 mmol) in tetrahydrofuran (THF, 25 mL) was slowly added n-butyllithium (n-BuLi, 1.6 M solution in hexane, 11.0 mL, 17.7 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 40 min, followed by the addition of trimethyl borate (2.7 mL, 24.3 mmol). The reaction system was slowly warmed from -78 °C to room temperature and stirring was continued at this temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 1.0 N hydrochloric acid (40 mL) and subsequently extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). After removal of solvent by evaporation under reduced pressure, the crude product obtained was purified by grinding with a solvent mixture of ethyl acetate/hexane (1:4, v/v). After filtration, the target product 4-fluoro-3-methoxyphenylboronic acid (0.75 g, 35% yield) was obtained as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, methanol-d4) with chemical shifts of δ 3.86 (s, 3H) and 7.03-7.45 (m, 3H).

References

[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71

4-FLUORO-3-METHOXYPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-3-METHOXYPHENYLBORONIC ACID Suppliers

Americas 1 China 128 Europe 1 France 1 Germany 4 India 5 Japan 2 United Kingdom 4 United States 23 Global 169

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View Lastest Price from 4-FLUORO-3-METHOXYPHENYLBORONIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 854778-31-7
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 854778-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 854778-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

854778-31-7, 4-FLUORO-3-METHOXYPHENYLBORONIC ACIDRelated Search:

3-Methoxy-2,4,6-trifluorophenylboronic acid 3-(Benzyloxy)-4-fluorophenylboronic acid 3-ISOPROPOXY-2,4,6-TRIFLUOROBENZENEBORONIC ACID 3-BUTOXY-2,4,6-TRIFLUOROPHENYLBORONIC A& 4-FLUORO-3-METHOXYPHENYLBORONIC ACID 3-Ethoxy-4-fluorobenzeneboronic acid 6-Bromo-3-fluoro-2-methoxyphenylboronic acid 2-FLUORO-6-METHOXYPHENYLBORONIC ACID 3-ETHOXY-2,4,6-TRIFLUOROPHENYLBORONIC A& 3-Bromo-6-fluoro-2-methoxyphenylboronic acid 2,3-Difluoro-4-methoxyphenylboronic acid 4-FLUORO-2-METHOXYPHENYLBORONIC ACID 2-FLUORO-4-METHOXYPHENYLBORONIC ACID 2,5-DIFLUORO-4-METHOXYPHENYLBORONIC ACID 2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID 3-FLUORO-4-METHOXYPHENYLBORONIC ACID,3-Fluoro-4-methoxyphenylboronic acid ,98% 4-Bromo-2-fluoro-6-methoxyphenylboronic acid 2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Boronicacid, (4-fluoro-3-methoxyphenyl)- (9CI)

BORONICACID, (4-FLUORO-3-METHOXYPHENYL)- (9CI);

5-Borono-2-fluoroanisole

4-Fluoro-3-Methoxyphenylboronic Acid (contains varying aMounts of Anhydride)

4-Fluoro-5-methoxyphenylboronic acid

4-Fluoro-3-Methoxyphenylboronic

4-Fluoro-3-methoxybenzeneboronic acid 98%

4-Fluoro-3-methoxybenzeneboronicacid98%

4-FLUORO-3-METHOXYBENZENEBORONIC ACID

4-FLUORO-3-METHOXYPHENYLBORONIC ACID

uoro-3-methoxyphenyL

Boronic acid, B-(4-fluoro-3-methoxyphenyl)-

Elagolix Impurity 50

4-Fluoro-3-methoxybenzeneboronic acid(contains varying amounts of Anhydride)

854778-31-7

blocks

BoronicAcids

FluoroCompounds