4-Fluoro-2-methoxyphenylboronic acid
- Product Name
- 4-Fluoro-2-methoxyphenylboronic acid
- CAS No.
- 179899-07-1
- Chemical Name
- 4-Fluoro-2-methoxyphenylboronic acid
- Synonyms
- AKOS BRN-0234;5-Fluoroanisole-2-boronic acid;4-Fluoro-2-Methoxyphenylboroni;4-FLUORO-2-FORMYLPHENYLBORONIC ACID;2-METHOXY-4-FLUOROPHENYLBORONIC ACID;4-FLUORO-2-METHOXYPHENYLBORONIC ACID;4-FLUORO-2-METHOXYBENZENEBORONIC ACID;B-(4-Fluoro-2-methoxyphenyl)boronic acid;4-fluoro-2-methoxyphenylboronic acid 98%;BORONIC ACID,B-(4-FLUORO-2-METHOXYPHENYL)-
- CBNumber
- CB9379998
- Molecular Formula
- C7H8BFO3
- Formula Weight
- 169.95
- MOL File
- 179899-07-1.mol
4-Fluoro-2-methoxyphenylboronic acid Property
- Melting point:
- 131-136 °C (lit.)
- Boiling point:
- 294.8±50.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.69±0.58(Predicted)
- form
- Crystalline Powder
- color
- White
- InChI
- InChI=1S/C7H8BFO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4,10-11H,1H3
- InChIKey
- ADJBXDCXYMCCAD-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(F)C=C1OC)(O)O
- CAS DataBase Reference
- 179899-07-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36-60-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 564494
- Product name
- 4-Fluoro-2-methoxyphenylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $78.3
- Updated
- 2025/07/31
- Product number
- 564494
- Product name
- 4-Fluoro-2-methoxyphenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $33
- Updated
- 2023/06/20
- Product number
- F1062
- Product name
- 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- F1062
- Product name
- 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $334
- Updated
- 2025/07/31
- Product number
- F595673
- Product name
- 4-Fluoro-2-methoxyphenylboronic acid
- Packaging
- 25g
- Price
- $435
- Updated
- 2021/12/16
4-Fluoro-2-methoxyphenylboronic acid Chemical Properties,Usage,Production
Uses
suzuki reaction
Uses
Reactant involved in:
Suzuki-Miyaura cross-coupling reactions for synthesis of heterobiaryls
Suzuki and Still coupling for synthesis of antithrombotic drugs
Reactant / precursor used for the synthesis of biologically active molecules including:
2-(4-pyridyl)thienopyridinones for use as GSK-3β inhibitors
Arylheteroarylmethylamines as NR2B subtype of NMDA receptor antagonists with antidepressant activity
Biphenylketones for use as dual modulators of inflammation and bone loss
CB1 antagonists
Synthesis
121-43-7
450-88-4
179899-07-1
4-Fluoro-2-methoxyphenylboronic acid was synthesized as follows: 2-bromo-5-fluoroanisole (5.9 g, 29 mmol) and anhydrous tetrahydrofuran (50 mL) were added to a dry round-bottomed flask under argon protection. After cooling the reaction system to -78°C, n-butyllithium (17.4 mL, 43.5 mmol) was added slowly and dropwise. After stirring the reaction at -78°C for 30 minutes, trimethyl borate (4.9 mL, 43.5 mmol) was added, followed by a slow warming of the reaction mixture to room temperature (~1.3 hours). After completion of the reaction, the mixture was cooled to 0°C and acidified by adding 10% aqueous hydrochloric acid (20 mL). Tetrahydrofuran was removed by distillation under reduced pressure and saturated saline (50 mL) was added. The aqueous phase was extracted twice with ether. The organic phases were combined and washed sequentially with 10% aqueous hydrochloric acid and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellow solid product 4-fluoro-2-methoxyphenylboronic acid (4 g, 82% yield). The product was characterized by 1H NMR (400 MHz, acetone-d6): δ 7.84 (t, 1H, J = 8 Hz, C6-H), 6.85 (dd, 1H, J = 12.2 Hz, C3-H), 6.76 (td, 1H, J = 8, 2 Hz, C5-H).
References
[1] Patent: US2004/6134, 2004, A1
4-Fluoro-2-methoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Fluoro-2-methoxyphenylboronic acid Suppliers
- Tel
- 19150199476
- 2035843955@qq.com
- Country
- China
- ProdList
- 58
- Advantage
- 58
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
View Lastest Price from 4-Fluoro-2-methoxyphenylboronic acid manufacturers
- Product
- 4-Fluoro-2-methoxyphenylboronic acid 179899-07-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-Fluoro-2-methoxyphenylboronic acid 179899-07-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 4-Fluoro-2-methoxyphenylboronic acid 179899-07-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg;5kg;100kg
- Release date
- 2019-07-04