ChemicalBook > CAS DataBase List > 4-Fluoro-2-methoxyphenylboronic acid

4-Fluoro-2-methoxyphenylboronic acid

Product Name: 4-Fluoro-2-methoxyphenylboronic acid
CAS No.: 179899-07-1
Chemical Name: 4-Fluoro-2-methoxyphenylboronic acid
Synonyms: AKOS BRN-0234;5-Fluoroanisole-2-boronic acid;4-Fluoro-2-Methoxyphenylboroni;4-FLUORO-2-FORMYLPHENYLBORONIC ACID;2-METHOXY-4-FLUOROPHENYLBORONIC ACID;4-FLUORO-2-METHOXYPHENYLBORONIC ACID;4-FLUORO-2-METHOXYBENZENEBORONIC ACID;B-(4-Fluoro-2-methoxyphenyl)boronic acid;4-fluoro-2-methoxyphenylboronic acid 98%;BORONIC ACID,B-(4-FLUORO-2-METHOXYPHENYL)-
CBNumber: CB9379998
Molecular Formula: C7H8BFO3
Formula Weight: 169.95
MOL File: 179899-07-1.mol

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4-Fluoro-2-methoxyphenylboronic acid Property

Melting point:: 131-136 °C (lit.)
Boiling point:: 294.8±50.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 8.69±0.58(Predicted)
form: Crystalline Powder
color: White
InChI: InChI=1S/C7H8BFO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4,10-11H,1H3
InChIKey: ADJBXDCXYMCCAD-UHFFFAOYSA-N
SMILES: B(C1=CC=C(F)C=C1OC)(O)O
CAS DataBase Reference: 179899-07-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-36-60-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 564494
Product name: 4-Fluoro-2-methoxyphenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $78.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 564494
Product name: 4-Fluoro-2-methoxyphenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $33
Updated: 2023/06/20

TCI Chemical

Product number: F1062
Product name: 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: F1062
Product name: 4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $334
Updated: 2025/07/31

TRC

Product number: F595673
Product name: 4-Fluoro-2-methoxyphenylboronic acid
Packaging: 25g
Price: $435
Updated: 2021/12/16

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4-Fluoro-2-methoxyphenylboronic acid Chemical Properties,Usage,Production

Uses

suzuki reaction

Uses

Reactant involved in:
Suzuki-Miyaura cross-coupling reactions for synthesis of heterobiaryls
Suzuki and Still coupling for synthesis of antithrombotic drugs
Reactant / precursor used for the synthesis of biologically active molecules including:
2-(4-pyridyl)thienopyridinones for use as GSK-3β inhibitors
Arylheteroarylmethylamines as NR2B subtype of NMDA receptor antagonists with antidepressant activity
Biphenylketones for use as dual modulators of inflammation and bone loss
CB1 antagonists

Synthesis

121-43-7

450-88-4

179899-07-1

4-Fluoro-2-methoxyphenylboronic acid was synthesized as follows: 2-bromo-5-fluoroanisole (5.9 g, 29 mmol) and anhydrous tetrahydrofuran (50 mL) were added to a dry round-bottomed flask under argon protection. After cooling the reaction system to -78°C, n-butyllithium (17.4 mL, 43.5 mmol) was added slowly and dropwise. After stirring the reaction at -78°C for 30 minutes, trimethyl borate (4.9 mL, 43.5 mmol) was added, followed by a slow warming of the reaction mixture to room temperature (~1.3 hours). After completion of the reaction, the mixture was cooled to 0°C and acidified by adding 10% aqueous hydrochloric acid (20 mL). Tetrahydrofuran was removed by distillation under reduced pressure and saturated saline (50 mL) was added. The aqueous phase was extracted twice with ether. The organic phases were combined and washed sequentially with 10% aqueous hydrochloric acid and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellow solid product 4-fluoro-2-methoxyphenylboronic acid (4 g, 82% yield). The product was characterized by 1H NMR (400 MHz, acetone-d6): δ 7.84 (t, 1H, J = 8 Hz, C6-H), 6.85 (dd, 1H, J = 12.2 Hz, C3-H), 6.76 (td, 1H, J = 8, 2 Hz, C5-H).

References

[1] Patent: US2004/6134, 2004, A1

4-Fluoro-2-methoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Fluoro-2-methoxyphenylboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Fluoro-2-methoxyphenylboronic acid 179899-07-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Fluoro-2-methoxyphenylboronic acid 179899-07-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 4-Fluoro-2-methoxyphenylboronic acid 179899-07-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg;5kg;100kg
Release date: 2019-07-04

179899-07-1, 4-Fluoro-2-methoxyphenylboronic acidRelated Search:

4-Methoxybenzyl alcohol 4-Fluorobenzeneboronic acid 4-Methoxybenzoyl chloride (4-METHOXYPHENYL)-BORANE 3-Methoxyacetophenone p-Anisaldehyde 4-Methoxybenzyl cyanide Anisole 2,3,4-Trimethoxybenzaldehyde (Trifluoromethoxy)benzene 4-Methoxyphenylboronic acid Phenylboronic acid 2-ETHOXY-4-FLUOROPHENYLBORONIC ACID 4-FLUORO-2-PROPOXYPHENYLBORONIC ACID 4-FLUORO-2-ISOPROPOXYPHENYLBORONIC ACID 4,5-DIFLUORO-2-METHOXYPHENYLBORONIC ACID 2-BUTOXY-4-FLUOROPHENYLBORONIC ACID Fluorine

BORONIC ACID,B-(4-FLUORO-2-METHOXYPHENYL)-

4-Fluoro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)

B-(4-Fluoro-2-methoxyphenyl)boronic acid

2-METHOXY-4-FLUOROPHENYLBORONIC ACID

4-FLUORO-2-METHOXYBENZENEBORONIC ACID

4-FLUORO-2-METHOXYPHENYLBORONIC ACID

AKOS BRN-0234

4-FLUORO-2-FORMYLPHENYLBORONIC ACID

4-Fluoro-2-Methoxyphenylboroni

5-Fluoroanisole-2-boronic acid

4-fluoro-2-methoxyphenylboronic acid 98%

4-Fluoro-2-methoxyphenylboronic acid - [F3266]

179899-07-1

Organometallic Reagents

Aryl

Boronic Acids

Boronic Acids and Derivatives

blocks

BoronicAcids

FluoroCompounds

Boronic acid

Aryl

Boronic Acids

Boronic Acids and Derivatives

Boronic Acids