3-Fluoro-4-methoxybenzeneboronic acid

Product Name: 3-Fluoro-4-methoxybenzeneboronic acid
CAS No.: 149507-26-6
Chemical Name: 3-Fluoro-4-methoxybenzeneboronic acid
Synonyms: AKOS BRN-0215;3-Fluoro-4-methoxybe;uoro-4-methoxyphenyL;4-Borono-2-fluoroanisole;3-Fluoro-4-Methoxyphenylboroni;3-Fluoro-4-methoxybenzeneboronicaci;4-Methoxy-3-fluorophenylboronic acid;3-FLUORO-4-METHOXYPHENYLBORONIC ACID;3-FLUORO-4-METHOXYBENZENEBORONIC ACID;3-Fluoro-4-methyloxyphenylboronic acid
CBNumber: CB6353010
Molecular Formula: C7H8BFO3
Formula Weight: 169.95
MOL File: 149507-26-6.mol

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3-Fluoro-4-methoxybenzeneboronic acid Property

Melting point:: 206-211 °C (lit.)
Boiling point:: 318.1±52.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder
pka: 7.87±0.10(Predicted)
color: White to Light yellow to Light orange
BRN: 7370120
CAS DataBase Reference: 149507-26-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36/37/39-36-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 564036
Product name: 3-Fluoro-4-methoxyphenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $44.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: 564036
Product name: 3-Fluoro-4-methoxyphenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $187
Updated: 2023/06/20

TCI Chemical

Product number: F0876
Product name: 3-Fluoro-4-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: F0876
Product name: 3-Fluoro-4-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $99
Updated: 2025/07/31

TRC

Product number: F595663
Product name: 3-Fluoro-4-methoxyphenylboronic acid
Packaging: 5g
Price: $75
Updated: 2021/12/16

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3-Fluoro-4-methoxybenzeneboronic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

3-Fluoro-4-methoxyphenylboronic Acid is a useful reagent for regioselective Suzuki coupling reactions and other synthetic transformations.

Uses

Reactant for:

Preparation of hydroxyphenylnaphthols as 17?-hydroxysteroid dehydrogenase Type 2 inhibitors
Regioselective Suzuki coupling
Ruthenium-catalyzed arylation reactions
Synthesis of amino-trimethoxyphenyl-aryl thiazoles as microtubule inhibitors and potential antitumors
Rhodium catalyzed cyanation
Petasis reaction

Uses

suzuki reaction

General Description

Contains varying amounts of anhydride

Synthesis

5419-55-6

2357-52-0

149507-26-6

3-Fluoro-4-methoxyphenylboronic acid was synthesized as follows: using 4-bromo-2-fluoroanisole (10 g, 0.049 mol) as starting material, n-butyllithium (23.4 mL of 2.5 M hexane solution, 0.059 mol) was added dropwise under anhydrous and oxygen-free conditions at -78°C and the reaction was stirred for 1 hour. Subsequently, triisopropyl borate (45.2 mL, 36.9 g, 0.196 mol) was slowly added and the reaction mixture was gradually warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of dilute hydrochloric acid, extracted with ethyl acetate and the organic phase was dried over anhydrous sodium sulfate and concentrated. The crude product was purified by column chromatography to afford 7.1 g of 3-fluoro-4-methoxyphenylboronic acid as white solid in 85.2% yield. The product was confirmed by mass spectrometry (ESI), m/z 169 (MH)-; 1H NMR (DMSO-d6) data were as follows: δ 3.84 (3H, s), 7.10-7.16 (1H, m), 7.51-7.60 (2H, m).

References

[1] Patent: US2003/181519, 2003, A1

3-Fluoro-4-methoxybenzeneboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-methoxybenzeneboronic acid Suppliers

Americas 1 China 191 Europe 4 France 4 Germany 15 India 15 Italy 1 Japan 3 Jordan 1 Russia 1 Switzerland 3 United Kingdom 17 United States 62 Global 318

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View Lastest Price from 3-Fluoro-4-methoxybenzeneboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Fluoro-4-methoxybenzeneboronic acid 149507-26-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Fluoro-4-methoxybenzeneboronic acid 149507-26-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 3-Fluoro-4-methoxybenzeneboronic acid 149507-26-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2018-12-17

149507-26-6, 3-Fluoro-4-methoxybenzeneboronic acidRelated Search:

4-Methoxybenzoic acid 4-Methoxybenzyl alcohol 4-Tolylboronic acid p-Anisaldehyde 4-(Trifluoromethoxy)aniline (4-METHOXYPHENYL)-BORANE (Trifluoromethoxy)benzene 3-Methoxyacetophenone 4-Methoxybenzyl cyanide Phenylboronic acid 4-Methoxybenzoyl chloride 4-Methoxyphenylboronic acid Anisole Fluorine 4-Benzyloxy-2,3-difluorobenzeneboronic acid 4-BUTOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 2,5-DIFLUORO-4-METHOXYPHENYLBORONIC ACID 4-(Benzyloxy)-3-fluorophenylboronic acid

AKOS BRN-0215

3-FLUORO-4-METHOXYPHENYLBORONIC ACID

3-FLUORO-4-METHOXYBENZENEBORONIC ACID

3-Fluoro-4-Methoxyphenylboroni

3-Fluoro-4-methyloxyphenylboronic acid

4-Methoxy-3-fluorophenylboronic acid

Boronicacid, B-(3-fluoro-4-methoxyphenyl)-

3-Fluoro-4-methoxybenzeneboronic acid, 98+%

3-Fluoro-4-methoxyphenylboronic acid ,98%

3-Fluoro-4-methoxybe

(3-fluoro-4-methoxyphenyl)boronic acid(SALTDATA: FREE)

3-Fluoro-4-Methoxyphenylboronic acid (contains varying aMounts of Anhydride)

4-Borono-2-fluoroanisole

uoro-4-methoxyphenyL

3-Fluoro-4-methoxybenzeneboronicaci

3-Fluoro-4-methoxyphenylboronic acid - [F3260]

149507-26-6

149507-26-61

49507-26-6

C7H8BFO3

Organometallic Reagents

BORONIC ACID

Boronic Acids and Derivatives

Boronic Acids

Aryl

Boronic Acids

Boronic Acids and Derivatives

Boronic Acids

Boronate Ester

Potassium Trifluoroborate

Substituted Boronic Acids

Boronic Acid

Aryl

Fluorinated

Organoborons

blocks

BoronicAcids