ChemicalBook > CAS DataBase List > 5-HYDROXYOXINDOLE

5-HYDROXYOXINDOLE

Product Name: 5-HYDROXYOXINDOLE
CAS No.: 3416-18-0
Chemical Name: 5-HYDROXYOXINDOLE
Synonyms: 5-HYDROXYINDOLIN-2-ONE;5-HYDROXY-2-INDOLINONE;5-HYDROXY-1,3-DIHYDRO-INDOL-2-ONE;5-HYDROXYOXINDOLE;1H-indole-5-peroxol;5-Hydroxy-2-oxindole;5-hydroxyindol-2-one;5-Hydroxy-2-oxyindole;Sunitinib Impurity 67;5-Hydroxyindoline-2-one
CBNumber: CB9238091
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 3416-18-0.mol

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5-HYDROXYOXINDOLE Property

Melting point:: 156-157 °C(Solv: ethanol (64-17-5))
Boiling point:: 419.9±45.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 9?+-.0.20(Predicted)
color: Light brown to brown
CAS DataBase Reference: 3416-18-0(CAS DataBase Reference)

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Safety

Risk Statements: 43
Safety Statements: 36/37
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS004194
Product name: 5-hydroxyoxindole
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 100 mg
Price: $73.1
Updated: 2025/07/31

TRC

Product number: H953538
Product name: 5-Hydroxyindolin-2-one
Packaging: 500mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: V2187
Product name: 5-Hydroxyoxindole
Packaging: 1g
Price: $131
Updated: 2021/12/16

ChemScene

Product number: CS-W001542
Product name: 5-Hydroxyoxindole
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: OR910617
Product name: 5-Hydroxyoxindole
Purity: 95%
Packaging: 1g
Price: $160
Updated: 2021/12/16

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5-HYDROXYOXINDOLE Chemical Properties,Usage,Production

Uses

5-Hydroxyoxindole is a structural analog of uric acid. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders[1].

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 1279, 1988 DOI: 10.1002/jhet.5570250501

Synthesis

59-48-3

3416-18-0

The general procedure for the synthesis of 5-hydroxyindol-2-one from 2-indolone was as follows: the target compound 1 was prepared according to the method described by Itoh et al [22]. The procedure was as follows: 799 mg (6.0 mmol) of hydroxyindole was dissolved in 40 mL of aqueous dichloromethane at room temperature, followed by the addition of 3.1 g (7.2 mmol) of phenyl iodine (III)-bis (trifluoroacetate) (PIFA) in batches and 4.6 mL of trifluoroacetic acid. The reaction mixture was stirred overnight at room temperature and then evaporated to remove the dichloromethane. To the residue, 60 mL of 5% sodium bicarbonate solution and 50 mL of ethyl acetate were added, and the organic layer was separated through a partition funnel. The aqueous layer was extracted with 50 mL of ethyl acetate, and the combined organic layers were dried over anhydrous sodium sulfate, filtered, and the solvent evaporated under reduced pressure. The crude product was purified by column chromatography (silica gel, dichloromethane/methanol=9:1 (v/v)) to afford 627 mg (70% yield) of target compound 1 as light brown crystals. Melting point: 266-268 °C (literature value: 260-263 °C).1H NMR (DMSO-d6, δ ppm): 3.36 (s, 2H, H-3); 6.55 (d, 1H, J=8.6 Hz, H-6); 6.60 (d, 1H, J=8.7 Hz, H-7); 6.66 (s, 1H, H-4); 8.93 (s, 1H, OH); 10.47 (s, 1H, NH).ESI-MS (ES-): m/z=148 [M-H]-.

References

[1] Daisuke Yasuda, et al. Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives.

5-HYDROXYOXINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-HYDROXYOXINDOLE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-HYDROXYOXINDOLE 3416-18-0
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-25

Chemwill Asia Co.,Ltd.

Product: 5-Hydroxy-2-oxindole ; 5-HYDROXYOXINDOLE; in stock Factory 3416-18-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: High quality purified Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 5-HYDROXYOXINDOLE 3416-18-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

3416-18-0, 5-HYDROXYOXINDOLERelated Search:

5-Hydroxyindole 2,3-DIHYDROINDOL-5-OL 5-Methoxyisatin 5-Methoxyoxindole 5-(TRIFLUOROMETHOXY)ISATIN 5-HYDROXYOXINDOLE 4-HYDROXYOXINDOLE 6-HYDROXYOXINDOLE Oxindole 5-METHOXY-1-METHYL-1H-INDOLE-2,3-DIONE AKOS BBS-00005457 5,6-DIMETHOXY-1,3-DIHYDRO-INDOL-2-ONE AKOS BBS-00005462 AKOS BBS-00005453 7-Hydroxyoxindole AKOS BBS-00005979 5-phenoxy-1H-indole-2,3-dione AKOS BBS-00005978

5-HYDROXY-2-INDOLINONE

5-HYDROXY-1,3-DIHYDRO-INDOL-2-ONE

5-HYDROXYINDOLIN-2-ONE

5-HYDROXYOXINDOLE

2H-INDOL-2-ONE, 1,3-DIHYDRO-5-HYDROXY-

2,3-dihydro-5-hydroxyindol-2-one

1,3-Dihydro-5-hydroxy-2H-indol-2-one

5-Hydroxy-2-oxindole

5-Hydroxy-1H-indole-2(3H)-one

5-Hydroxy-2,3-dihydro-1H-indol-2-one

5-Hydroxy-2,3-dihydro-1H-indole-2-one

5-Hydroxyindoline-2-one

5-Hydroxy-2-oxyindole

5-hydroxyindol-2-one

1H-indole-5-peroxol

Sunitinib Impurity 67

3416-18-0

pharmacetical

Indoline & Oxindole

Indoles and derivatives