5-HYDROXYOXINDOLE
- Product Name
- 5-HYDROXYOXINDOLE
- CAS No.
- 3416-18-0
- Chemical Name
- 5-HYDROXYOXINDOLE
- Synonyms
- 5-HYDROXYINDOLIN-2-ONE;5-HYDROXY-2-INDOLINONE;5-HYDROXY-1,3-DIHYDRO-INDOL-2-ONE;5-HYDROXYOXINDOLE;1H-indole-5-peroxol;5-Hydroxy-2-oxindole;5-hydroxyindol-2-one;5-Hydroxy-2-oxyindole;Sunitinib Impurity 67;5-Hydroxyindoline-2-one
- CBNumber
- CB9238091
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 3416-18-0.mol
5-HYDROXYOXINDOLE Property
- Melting point:
- 156-157 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 419.9±45.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 9?+-.0.20(Predicted)
- color
- Light brown to brown
- CAS DataBase Reference
- 3416-18-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS004194
- Product name
- 5-hydroxyoxindole
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- H953538
- Product name
- 5-Hydroxyindolin-2-one
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-W001542
- Product name
- 5-Hydroxyoxindole
- Packaging
- 100mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- CS-W001542
- Product name
- 5-Hydroxyoxindole
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- V2187
- Product name
- 5-Hydroxyoxindole
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
5-HYDROXYOXINDOLE Chemical Properties,Usage,Production
Uses
5-Hydroxyoxindole is a structural analog of uric acid. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders[1].
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 25, p. 1279, 1988 DOI: 10.1002/jhet.5570250501
Synthesis
59-48-3
3416-18-0
The general procedure for the synthesis of 5-hydroxyindol-2-one from 2-indolone was as follows: the target compound 1 was prepared according to the method described by Itoh et al [22]. The procedure was as follows: 799 mg (6.0 mmol) of hydroxyindole was dissolved in 40 mL of aqueous dichloromethane at room temperature, followed by the addition of 3.1 g (7.2 mmol) of phenyl iodine (III)-bis (trifluoroacetate) (PIFA) in batches and 4.6 mL of trifluoroacetic acid. The reaction mixture was stirred overnight at room temperature and then evaporated to remove the dichloromethane. To the residue, 60 mL of 5% sodium bicarbonate solution and 50 mL of ethyl acetate were added, and the organic layer was separated through a partition funnel. The aqueous layer was extracted with 50 mL of ethyl acetate, and the combined organic layers were dried over anhydrous sodium sulfate, filtered, and the solvent evaporated under reduced pressure. The crude product was purified by column chromatography (silica gel, dichloromethane/methanol=9:1 (v/v)) to afford 627 mg (70% yield) of target compound 1 as light brown crystals. Melting point: 266-268 °C (literature value: 260-263 °C).1H NMR (DMSO-d6, δ ppm): 3.36 (s, 2H, H-3); 6.55 (d, 1H, J=8.6 Hz, H-6); 6.60 (d, 1H, J=8.7 Hz, H-7); 6.66 (s, 1H, H-4); 8.93 (s, 1H, OH); 10.47 (s, 1H, NH).ESI-MS (ES-): m/z=148 [M-H]-.
References
[1] Daisuke Yasuda, et al. Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives.
5-HYDROXYOXINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
5-HYDROXYOXINDOLE Suppliers
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 5-HYDROXYOXINDOLE manufacturers
- Product
- 5-HYDROXYOXINDOLE 3416-18-0
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-25
- Product
- 5-Hydroxy-2-oxindole ; 5-HYDROXYOXINDOLE; in stock Factory 3416-18-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- High quality purified Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03
- Product
- 5-HYDROXYOXINDOLE 3416-18-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08