ChemicalBook > CAS DataBase List > Borane-tetrahydrofuran complex

Borane-tetrahydrofuran complex

Product Name
Borane-tetrahydrofuran complex
CAS No.
14044-65-6
Chemical Name
Borane-tetrahydrofuran complex
Synonyms
BH3-THF;BORANE;Trihydro(tetrahydrofuran)boron;BORANE TETRAHYDROFURAN COMPLEX;BORANE-TETRAHYDROFURAN;BTHF;Borane, 1M in tetrahydrofuran;Borane-tetrahydrofuran complex, 1M soln. in THF, packaged under Argon in resealable ChemSeal^t bottl;Borane-tetrahydrofuran complex, 1M soln. in THF, packaged under Argon in resealable ChemSealTM bottles;DKK33
CBNumber
CB9239528
Molecular Formula
C4H11BO
Formula Weight
85.94
MOL File
14044-65-6.mol
More
Less

Borane-tetrahydrofuran complex Property

Melting point:
-17 °C
Boiling point:
35 °C
Density 
0.898 g/mL at 25 °C
Flash point:
1 °F
storage temp. 
Store at <= 20°C.
form 
Liquid
color 
Colorless
Water Solubility 
REACTS
Sensitive 
Air & Moisture Sensitive
BRN 
3668402
Exposure limits
ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
Stability:
Stable, but may form explosive peroxides in contact with air. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents, alcohols. Reacts violently with water. Highly flammable. Store under inert gas.
CAS DataBase Reference
14044-65-6(CAS DataBase Reference)
EPA Substance Registry System
Boron, trihydro(tetrahydrofuran)-, (T-4)- (14044-65-6)
More
Less

Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
14/15-19-22-36/37/38-41-37/38-11-67-66-40-36/37
Safety Statements 
16-33-36/37/39-7/9-7/8-43-37/39-26-36-29-36/37
RIDADR 
UN 3399 4.3/PG 1
WGK Germany 
3
1-10-13-34
TSCA 
Yes
HazardClass 
4.3
PackingGroup 
I
HS Code 
29321900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H260In contact with water releases flammable gases which may ignite spontaneously

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H333May be harmful if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.

P231+P232Handle under inert gas. Protect from moisture.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P402+P404Store in a dry place. Store in a closed container.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
176192
Product name
Borane tetrahydrofuran complex solution
Purity
1.0 M in THF
Packaging
4x25ml
Price
$60.8
Updated
2024/03/01
Sigma-Aldrich
Product number
176192
Product name
Borane tetrahydrofuran complex solution
Purity
1.0 M in THF
Packaging
100ml
Price
$63.9
Updated
2024/03/01
TCI Chemical
Product number
T2346
Product name
Borane - Tetrahydrofuran Complex (8.5% in Tetrahydrofuran, ca. 0.9mol/L) (stabilized with Sodium Borohydride)
Packaging
25ML
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
T2346
Product name
Borane - Tetrahydrofuran Complex (8.5% in Tetrahydrofuran, ca. 0.9mol/L) (stabilized with Sodium Borohydride)
Packaging
100mL
Price
$205
Updated
2024/03/01
TCI Chemical
Product number
T2346
Product name
Borane - Tetrahydrofuran Complex (8.5% in Tetrahydrofuran, ca. 0.9mol/L) (stabilized with Sodium Borohydride)
Packaging
500mL
Price
$833
Updated
2024/03/01
More
Less

Borane-tetrahydrofuran complex Chemical Properties,Usage,Production

Description

Borane tetrahydrofuran complex (BH3-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.It is a charge-transfer complex that is a useful surrogate for diborane1 in organic synthesis. It can be used to reduce carboxylic acids to alcohols or nitriles to primary amines. It reacts with olefins to add the BH2 functional group. Alkyl- or arylboranes formed in this way can further react with unsaturated compounds such as olefins, imines, ketones, and alkynes (the hydroboration reaction) to make useful boron-containing intermediates.

Chemical Properties

colourless liquid

Uses

Borane-tetrahydrofuran complex is used to reduce Nylon surface amide groups to secondary amines.It is an important reagent used in the reduction of certain functional groups viz. aldehyde, ketone, carboxylic acid, amide, oxime, imine and nitrile. It is also used as hydro borating agent. It acts as a borane source for oxazaborolidine catalyzed asymmetric reductions.

Uses

Borane-tetrahydrofuran complex is an important reagent used in the reduction of certain functional groups viz. aldehyde, ketone, carboxylic acid, amide, oxime, imine and nitrile. It is also used as hydro borating agent. It acts as a borane source for oxazaborolidine catalyzed asymmetric reductions. It is utilized to reduce nylon surface amide groups to secondary amines.

Application

New, Safer, NIMBA-Stabilized BH3 THF Solutions
BH3-THF can be used as a reducing agent for the reduction of various functional groups such as carboxylic acids, aldehydes, ketones, esters, acid chlorides, nitriles, epoxides, amides, lactones, oximes, and imines into corresponding alcohols and amines. Grignard reagents, arylmercury, arylthalium, and allyl and propargyllithium compounds react with BH3?THF to give organoboranes, which can be oxidized to the corresponding alcohols, phenols, and 1,3-diols.
It can also be used:
To synthesize the chiral borane catalyst, which is used in the enantioselective halo-aldol reaction.
To prepare 9-unsubstituted acridines by reduction of corresponding acridones.
To reduce nylon surface amide groups to secondary amines.

Reactions

Borane-tetrahydrofuran complex (BTHF) is a valuable reagent for the reduction of functional groups and for hydroboration reactions with carbon-carbon double and triple bonds. Functional groups that are readily reduced by BTHF include aldehyde, ketone, carboxylic acid, amide, oxime, imine, and nitrile. The carboxylic acid group is reduced at a faster rate than most groups including non-conjugated alkene. Conjugated α,β-unsaturated carboxylic acids give saturated alcohols as the major products.
Ketones and the carbonyl of enones are effectively reduced with borane-tetrahydrofuran. The addition of borohydride to the reaction solution is advantageous for accelerated reduction as well as higher selectivity towards carbonyl reduction in conjugated and non-conjugated enones.

Asymmetric ketone reduction using chiral oxazaborolidine catalysts was recently reviewed. Work at Callery with BTHF improved on reaction conditions to provide consistent results in the reduction.

General Description

Borane tetrahydrofuran complex (BH3-THF) is widely used as a reducing agent in organic synthesis. It is also used as a reagent in hydroboration reactions.

Precautions

Air and moisture sensitive. Forms explosive peroxides in contact with air. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents and alcohols. On hydrolysis, it forms hydrogen and boric acid.

More
Less

Borane-tetrahydrofuran complex Suppliers

Viwit Pharmaceutical Co., Ltd.
Tel
0632-0632-2980981 15063270987
Fax
0632-2989678
Email
service.china3@viwit.com
Country
China
ProdList
135
Advantage
55
Shanghai Scientia Pharmaceutical Technology Co., Ltd.
Tel
21-21-54301573 13917723525
Fax
(86)21-51861981
Email
sales@scientiapharm.com
Country
China
ProdList
263
Advantage
62
Shanghai Forxine Pharmaceutical Co., Ltd.
Tel
21-21-64961388 18918697718
Fax
6496-1388-8320
Email
service@forxine.com
Country
China
ProdList
62
Advantage
60
Wuhan Chuangshuo Chemical Technology Co., Ltd
Tel
027-17773669204 17773669204
Email
3807504233@qq.com
Country
China
ProdList
298
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
More
Less

View Lastest Price from Borane-tetrahydrofuran complex manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Borane-tetrahydrofuran complex 14044-65-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-16
Hebei Weibang Biotechnology Co., Ltd
Product
Borane-tetrahydrofuran complex 14044-65-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Hebei Chuanghai Biotechnology Co,.LTD
Product
Borane-tetrahydrofuran complex 14044-65-6
Price
US $9.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-16

14044-65-6, Borane-tetrahydrofuran complexRelated Search:


  • borane-tetrahydrofurancomplex,bthf-1m
  • BORAN-TETRAHYDROFURANCOMPLEX
  • BORANE-TETRAHYDROFURANCOMPLEX,1MSOLUTIONINTETRAHYDROFURAN
  • Borane tetrahydrofuran complex 1.0 molar in THF
  • Borane-tetrahydrofuran complex, 1M soln. in THF, stab. with 5mmol NaBH4
  • Borane-tetrahydrofuran complex, 1M soln. in THF, packaged under Argon in resealable ChemSealTM bottles
  • Borane - Tetrahydrofuran Complex (8.5% in Tetrahydrofuran, ca. 0.9mol/L) (stabilized with Sodium Borohydride)
  • Borane, 1M in tetrahydrofuran
  • Borane dimethyl sulfide complex, 2M in tetrahydrofuran, packaged under Argon in resealable ChemSeal bottles
  • Borane, 1M in tetrahydrofuran, packaged under Argon in resealable ChemSeal bottles
  • Borane-tetrahydrofuran complex1M solution in THFStabilizedAcroSeal§3
  • Borane-tetrahydrofuran complex, 1M soln. in THF, packaged under Argon in resealable ChemSeal^t bottles
  • Borane-tetrahydrofuran complex, 1M soln. in THF, packaged under Argon in resealable ChemSeal^t bottl
  • Borane-tetrahydrofuran complex, 1M solution in THF, Stabilized, AcroSeal?
  • Brane-tetrahydrofurancomplex,bthf-1m
  • Borane tetrahydrofuran complex, 1.0 M solution
  • BH3-THF
  • Borane tetrahydrofuran complex solution, 1M in THF, stabilized
  • Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran, stabilized
  • Borane-tetrahydrofuran Complex, stabilized with 5mmol NaBH
  • Borane-Petrahydrofuran Complex
  • Borane - tetrahydrofuran (1:1)
  • Borane-tetrahydrofuran complex, 1.0 M solution in THF, stabilized, J&KSeal
  • Borane-tetrahydrofuran compL
  • Borane-tetrahydrofuran complex - 1.0M in THF
  • borane-tetrahydrofurancomplex,bthf-2m
  • TETRAHYDROFURAN BORANE
  • BORON HYDRIDE-TETRAHYDROFURAN COMPLEX
  • BORANE
  • BORANE-TETRAHYDROFURAN
  • BORANE TETRAHYDROFURAN COMPLEX
  • Borane-tetrahydrofuran complex, 1M solution tetrahydrofuran
  • Borane-tetrahydrofuran complex, 2M solution tetrahydrofuran
  • BORANE-TETRAHYDROFURAN COMPLEX, CA. 1.8M SOLUTION IN TETRAHYDROFURAN, TECH.
  • BORANE-TETRAHYDROFURAN COMPLEX 1.0M SO&
  • BORANE-TETRAHYDROFURAN COMPLEX, 1.0M SOLUTION IN TETRAHYDROFURAN
  • BORANE-TETRAHYDROFURAN COMPLEX, 1.5M SOL N IN TETRAHYDROFURAN AND ETHER, TECH.
  • BORANE TETRAHYDROFURAN COMPLEX SOLUTION, 4X10 ML
  • BORANE TETRAHYDROFURAN COMPLEX SOLUTION, ~1 M IN THF
  • Borane tetrahydrofuran complex solution
  • Borane-tetrahydrofuran complex, 1M solution in THF, stabilized
  • Borane,tetrahydrofurancomplex,1MinTHF
  • Boron, trihydro(tetrahydrofuran)-, (T-4)-
  • borane tetrahydrofuran complex, 1m soln. in thf
  • borane, 1m in tetrahydrofuran, packaged under argon in resealable chemseal
  • BTHF
  • Borane-tetrahydrofuran complex [1M solution in THF, stabilized with 0.005M NaBH4]
  • Borane, tetrahydrofuran complex, 1M in THF (stabilized with <0.005M sodium borohydride)
  • Trihydro(tetrahydrofuran)boron
  • Borane-tetrahydrofuran coMplex, 1M solution in THF, Stabilized, AcroSeal 800ML
  • (Borane tetrahydrofuran coMplex soiution)
  • Borane-tetrahydrofuran coMplex, 1.0 M solution in THF, stabilized
  • Borane tetrahydrofuran complex, 1M solution in THF
  • (Tetrahydro-1H-furan-1-iuM-1-yl)trihydroborate
  • Borane tetrahydrofuran coMplex solution 1.0 M in THF
  • Borane-tetrahydrofuran coMplex, 1.0 M solution in THF, SpcSeal
  • Borane tetrahydrofuran complex solution 1.0 M in THF, contains 0.005 M 1,2,2,6,6-pentamethylpiperidine as stabilizer
  • Borane tetrahydrofuran complex solution 1.0 M in THF, contains 0.005 M Sodium borohydride as stabilizer