HDH-PHARMA 26173

Product Name: HDH-PHARMA 26173
CAS No.: 871836-51-0
Chemical Name: HDH-PHARMA 26173
Synonyms: 4-CHLORO-1H-PYRAZOLO[4,3-C]PYRIDINE;1H-Pyrazolo[4,3-c]pyridine,4-chloro-;100182;EOS-61542;HDH-PHARMA 26173;4-chloro-1H-pyrazolo[4;4-Chloro-1H-pyrazolo[4,3-...;4-chloro-1H-pyrazolo[4,4-c]pyridine;4-Chloro-1H-pyrazolo[4,3-c]pyridine 98%;4-chloro-1H-pyrazolo[4,3-c]pyridin-6-aMine
CBNumber: CB92465688
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 871836-51-0.mol

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HDH-PHARMA 26173 Property

Boiling point:: 357.5±22.0 °C(Predicted)
Density: 1.531
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 10.46±0.40(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C6H4ClN3/c7-6-4-3-9-10-5(4)1-2-8-6/h1-3H,(H,9,10)
InChIKey: FUXZQGSDRGDYGX-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC2NN=CC1=2

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BLN00015
Product name: 4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging: 1g
Price: $1090
Updated: 2025/07/31

TRC

Product number: C379330
Product name: 4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging: 1g
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 067147
Product name: 4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging: 1g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-41
Product name: 4-Chloro-1H-pyrazolo[4,3-c]pyridine
Purity: 95%
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W8946
Product name: 4-Chloro-1H-pyrazolo[4,3-c]pyridine
Packaging: 1g
Price: $82
Updated: 2021/12/16

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HDH-PHARMA 26173 Chemical Properties,Usage,Production

Uses

4-Chloro-1H-pyrazolo[4,3-c]pyridine is used to prepare gp120-?CD4 inhibitors.

Synthesis

134031-24-6

871836-51-0

General procedure for the synthesis of 4-chloro-1H-pyrazolo[4,3-c]pyridine using 2,4-dichloronicotinaldehyde as starting material: intermediate 1 (1.7 g, 9.7 mmol) was dissolved in dimethoxyethane (12 ml) at room temperature, followed by addition of hydrazine monohydrate (1.2 ml, 38.6 mmol). The reaction mixture was stirred at 75°C overnight. Upon completion of the reaction, the mixture was concentrated to dryness and the resulting crude product was purified by fast chromatography using 20% to 100% ethyl acetate/petroleum ether gradient elution to afford the target product, 4-chloro-1H-pyrazolo[4,3-c]pyridine, as a white solid (0.82 g, 56% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.60 (d, J = 6.9 Hz, 1H), 8.14 (d, J = 6.0 Hz, 1H), 8.32 (s, 1H); mass spectra (ES + APCI)+: m/z 154 [M + H]+.

References

[1] Patent: WO2012/38743, 2012, A1. Location in patent: Page/Page column 82
[2] Patent: WO2010/106333, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 118
[4] Patent: EP2857400, 2015, A1. Location in patent: Paragraph 1032
[5] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0403

HDH-PHARMA 26173 Preparation Products And Raw materials

Raw materials

Preparation Products

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HDH-PHARMA 26173 Suppliers

China 165 India 3 United Kingdom 2 United States 10 Global 180

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Synthonix Inc

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Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

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Country: United States
ProdList: 6618
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SynQuest Laboratories, Inc.

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Country: United States
ProdList: 6871
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Riedel-de Haen AG

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Frontier Scientific, Inc.

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Matrix Scientific

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Sphinx Scientific Laboratory, LLC

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ProdList: 3343
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View Lastest Price from HDH-PHARMA 26173 manufacturers

Career Henan Chemical Co

Product: HDH-PHARMA 26173 871836-51-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-21

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