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Methyl 5-bromo-2-fluoronicotinate

Product Name
Methyl 5-bromo-2-fluoronicotinate
CAS No.
931105-37-2
Chemical Name
Methyl 5-bromo-2-fluoronicotinate
Synonyms
Methyl 5-bromo-2-fluoronicotinate;5-Bromo-2-fluoro-nicotinic acid methyl ester;Methyl 5-broMo-2-fluoropyridine-3-carboxylate;5-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 5-bromo-2-fluoro-, methyl ester
CBNumber
CB92471193
Molecular Formula
C7H5BrFNO2
Formula Weight
234.02
MOL File
931105-37-2.mol
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Methyl 5-bromo-2-fluoronicotinate Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Frontier Specialty Chemicals
Product number
Y14218
Product name
Methyl5-bromo-2-fluoronicotinate
Purity
98%
Packaging
1g
Price
$40
Updated
2021/12/16
Matrix Scientific
Product number
054271
Product name
Methyl 5-bromo-2-fluoronicotinate
Purity
95+%
Packaging
500mg
Price
$51
Updated
2021/12/16
Matrix Scientific
Product number
054271
Product name
Methyl 5-bromo-2-fluoronicotinate
Purity
95+%
Packaging
1g
Price
$79
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
Y14218
Product name
Methyl5-bromo-2-fluoronicotinate
Purity
98%
Packaging
5g
Price
$150
Updated
2021/12/16
Apolloscientific
Product number
PC200226
Product name
Methyl5-bromo-2-fluoronicotinate
Packaging
1g
Price
$195
Updated
2021/12/16
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Methyl 5-bromo-2-fluoronicotinate Chemical Properties,Usage,Production

Synthesis

29241-66-5

74-88-4

931105-37-2

General procedure for the synthesis of methyl 2-fluoro-5-bromonicotinate from 2-fluoro-5-bromonicotinic acid and iodomethane: 0.75 mL (12 mmol) of iodomethane and 2.5 g (18 mmol) of potassium carbonate were added to a solution of 2.0 g (9.1 mmol) of 5-bromo-2-fluoronicotinic acid in DMF (8 mL). The reaction mixture was stirred at room temperature for 20 hours. After the reaction was completed, water was added to the reaction mixture and then extracted with ethyl acetate. The organic layer was washed with water and dried with anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate) to afford methyl 2-fluoro-5-bromonicotinate 1.7 g (7.3 mmol, 80% yield) as a white solid. Mass spectra (CI, m/z): 234, 236 [M + 1]+. 1H-NMR spectrum (400 MHz, DMSO-d6) δ: 8.66 (dd, J = 1.3, 2.6 Hz, 1H), 8.56 (dd, J = 2.6, 8.2 Hz, 1H), 3.89 (s, 3H).

References

[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 1387; 1388

Methyl 5-bromo-2-fluoronicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5-bromo-2-fluoronicotinate Suppliers

China 78 Germany 1 India 1 United Kingdom 1 United States 9 Global 90
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931105-37-2, Methyl 5-bromo-2-fluoronicotinateRelated Search:


  • Methyl 5-broMo-2-fluoropyridine-3-carboxylate
  • 5-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester
  • Methyl 5-bromo-2-fluoronicotinate
  • 3-Pyridinecarboxylic acid, 5-bromo-2-fluoro-, methyl ester
  • 5-Bromo-2-fluoro-nicotinic acid methyl ester
  • 931105-37-2