ChemicalBook > CAS DataBase List > 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Product Name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- CAS No.
- 23002-51-9
- Chemical Name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Synonyms
- QC-1184;2-Chlor-purin;6-Chloropyrazolo[3,4-d]pyrimidine;6-Chlor-1H-pyrazolo<3,4-d>pyrimidin;6-Chloro-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyriMidine, 6-chloro-;6-chloro-1(2)H-pyrazolo[3,4-d]pyrimidine
- CBNumber
- CB92471517
- Molecular Formula
- C5H3ClN4
- Formula Weight
- 154.56
- MOL File
- 23002-51-9.mol
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6-Chloro-1H-pyrazolo[3,4-d]pyrimidine Property
- Melting point:
- >100°C (dec.)
- Boiling point:
- 287.9±23.0 °C(Predicted)
- Density
- 1.84±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 9.27±0.20(Predicted)
- color
- Pale Yellow
- Stability:
- Moisture Sensitive
- InChI
- InChI=1S/C5H3ClN4/c6-5-7-1-3-2-8-10-4(3)9-5/h1-2H,(H,7,8,9,10)
- InChIKey
- CZAPPYRAFCOFOL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C2C=NNC2=N1
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
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N-Bromosuccinimide Price
TRC
- Product number
- C380085
- Product name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
TRC
- Product number
- C380085
- Product name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 5g
- Price
- $1190
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC139423
- Product name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC139423
- Product name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068541
- Product name
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
- Purity
- >95%
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
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6-Chloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production
Uses
Pyrazolo[3,4-d]pyrimidines have a close structural resemblance to the substrates for the enzyme xanthine oxidase, hypoxanthine (6-hydroxypurine) and xanthine (2,6-dihydroxypurine). These compounds are capable of binding to the enzyme and strongly inhibit its activity. They have been studied for their role in the treatment and prophylaxis of hyperuricemia in human patients as well as potential anti-tumor agents.
Synthesis
To a stirred solution of hydrazine in THF, 2,4-Dichloro-pyrimidine-5-carbaldehyde was added and the mixture was stirred at room temperature for 30 min. The mixture was poured into water and extracted with EtOAc. The extract was dried with sodium sulfate and the solvent was removed to give an orange solid. Yield_82%
References
[1] Patent: US2005/277655, 2005, A1. Location in patent: Page/Page column 15
[2] Patent: CN105524048, 2016, A. Location in patent: Paragraph 0427; 0428
[3] Patent: WO2011/156698, 2011, A2. Location in patent: Page/Page column 52-53
6-Chloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine manufacturers
Hangzhou Milon Pharmatech Co.,Ltd.
- Product
- 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 23002-51-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 97.0%min；99.0%min
- Supply Ability
- 75KG/Batch
- Release date
- 2025-11-30
Shaanxi Dideu Medichem Co. Ltd
- Product
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine 23002-51-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
Career Henan Chemical Co
- Product
- 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine 23002-51-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08
23002-51-9, 6-Chloro-1H-pyrazolo[3,4-d]pyrimidineRelated Search:
6-CHLORO-1H-INDOL-3-METHYLAMINE
6-chloro-1H-pyrazolo[3,4-b]pyridine
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro-
6-Chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester
6-CHLORO-1H-PYRROLO[3,2-B]PYRIDINE
1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE, 6-CHLORO-
6-chloro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde
6-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
1H-Indole-3-aceticacid,6-chloro-(9CI)
6-Chloro-1H-pyrazolo[4,3-c]pyridine
6-Chloro-1H-pyrazolo[3,4-b]pyrazine
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
3H-Pyrazolo[4,3-c]pyridin-3-one, 6-chloro-1,2-dihydro-
6-Chloro-3H-imidazo[4,5-c]pyridine