5'-fluoro-2'-Iodoacetophenone
Notes- Product Name
- 5'-fluoro-2'-Iodoacetophenone
- CAS No.
- 914225-70-0
- Chemical Name
- 5'-fluoro-2'-Iodoacetophenone
- Synonyms
- 1-(5-fluoro-2-iodophenyl)ethan-1-one;1-(5-Fluoro-2-iodophenyl)ethanone;uoro-2'-iodoacetophenone;5'-Fluoro-2'-iodoacetophenon;5-FLUORO-2-IODOACEETOPHENONE;5'-fluoro-2'-Iodoacetophenone;5'-Fluoro-2'-iodoacetophenonec;5'-Fluoro-2'-iodoacetophenone,98%;5'-Fluoro-2'-iodoacetophenone, 98%;Ethanone, 1-(5-fluoro-2-iodophenyl)-
- CBNumber
- CB92476022
- Molecular Formula
- C8H6FIO
- Formula Weight
- 264.04
- MOL File
- 914225-70-0.mol
5'-fluoro-2'-Iodoacetophenone Property
- Boiling point:
- 269.5±25.0 °C(Predicted)
- Density
- 1.793
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- color
- Brown
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C8H6FIO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,1H3
- InChIKey
- NRLSRIONJVBZDT-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC(F)=CC=C1I)C
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F598775
- Product name
- 1-(5-Fluoro-2-iodophenyl)ethanone
- Packaging
- 2.5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 144400
- Product name
- 5'-Fluoro-2'-iodoacetophenone
- Purity
- 95%
- Packaging
- 1g
- Price
- $681
- Updated
- 2021/12/16
- Product number
- HCH0050627
- Product name
- 2'-IODO-5'-FLUOROACETOPHENONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1249.13
- Updated
- 2021/12/16
- Product number
- 144400
- Product name
- 5'-Fluoro-2'-iodoacetophenone
- Purity
- 95%
- Packaging
- 5g
- Price
- $2043
- Updated
- 2021/12/16
- Product number
- J97334
- Product name
- 5'-Fluoro-2'-Iodoacetophenone
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
5'-fluoro-2'-Iodoacetophenone Chemical Properties,Usage,Production
Notes
Light Sensitive. Incompatible with light and oxidizing agents.
Uses
5'-Fluoro-2'-iodoacetophenone is used as pharmaceutical intermediates.
Materials Uses
1-(5-Fluoro-2-iodophenyl)ethanone is a reactant in the preparation of PF-06463922, a potent macrocyclic ALK inhibitor as potential antitumor.
Synthesis
52548-63-7
105-53-3
914225-70-0
1. 5-Fluoro-2-iodobenzoic acid was dissolved in an appropriate amount of solvent, 13.87 mol/L thionyl chloride was added, heated to 60°C and the reaction was stirred overnight until complete clarification. The progress of the reaction was monitored by TLC (unfolding agent: petroleum ether/ethyl acetate=10/1). Upon completion of the reaction, the solvent was removed by evaporation, toluene was added and evaporated to dryness, and the resulting product was dissolved in ethyl acetate and set aside. 2. 3658 g of diethyl malonate was dissolved in 55 L of ethyl acetate, and 4762 g of magnesium chloride was slowly added at room temperature for 30 minutes. Subsequently 4877 g of triethylamine was added dropwise and stirring was continued for 30 minutes. The reaction mixture was cooled to 5°C in an ice bath, the organic phase was washed with saturated saline (10 L x 2) and stirred for 2 h at room temperature. The completion of the reaction was confirmed by TLC (unfolding agent: petroleum ether/ethyl acetate = 10/1). 3. The organic layer was separated and the solvent was evaporated to give a red oil. To the oily substance was added 12 L of a mixture consisting of acetic acid, water and concentrated sulfuric acid in the ratio of 6.6:4.4:1 by volume, heated to 100°C, and the reaction was stirred overnight. After completion of the reaction, the organic phase was washed with saturated saline (10 L x 2). 4. The organic phase was further washed with 0.5 N sodium hydroxide solution (30 L × 1) and saturated saline (10 L × 2). Finally, it was purified by silica gel column chromatography (unfolding agent: petroleum ether/ethyl acetate = 8/1) to give 3.6 kg of the target product 1-(5-fluoro-2-iodophenyl)ethanone.
References
[1] Patent: CN105732355, 2016, A. Location in patent: Paragraph 0024; 0030; 0034
5'-fluoro-2'-Iodoacetophenone Preparation Products And Raw materials
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View Lastest Price from 5'-fluoro-2'-Iodoacetophenone manufacturers
- Product
- 5'-fluoro-2'-Iodoacetophenone 914225-70-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 5'-fluoro-2'-Iodoacetophenone 914225-70-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500 kgs
- Release date
- 2024-07-08
- Product
- 1-(5-Fluoro-2-iodophenyl)ethanone 914225-70-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-29