Domperidone maleate

ChemicalBook > CAS DataBase List > Domperidone maleate

Product Name: Domperidone maleate
CAS No.: 99497-03-7
Chemical Name: Domperidone maleate
Synonyms: DOMEPRIDONE MALEATE;DOMPERIDONE MALEATE;E-Domperidone Maleate;Domperidone maleate((1:X);Domperidone Maleate IP/BP/Ph. Eur;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate;2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate;Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate
CBNumber: CB9247961
Molecular Formula: C26H28ClN5O6
Formula Weight: 541.99
MOL File: 99497-03-7.mol

Less

Domperidone maleate Property

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Very slightly soluble in water, sparingly soluble in dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent).
form: Solid
color: White to Off-White

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: D531115
Product name: Domperidone maleate
Packaging: 5mg
Price: $8250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007069
Product name: DOMPERIDONE MALEATE
Purity: 95.00%
Packaging: 100MG
Price: $885.31
Updated: 2021/12/16

AK Scientific

Product number: S484
Product name: Domperidone maleate
Packaging: 5mg
Price: $39
Updated: 2021/12/16

AK Scientific

Product number: S484
Product name: Domperidone maleate
Packaging: 25mg
Price: $88
Updated: 2021/12/16

AK Scientific

Product number: S484
Product name: Domperidone maleate
Packaging: 100mg
Price: $195
Updated: 2021/12/16

Less

Domperidone maleate Chemical Properties,Usage,Production

Description

Domperidone maleate is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Chemical Properties

Domperidone maleate occurs as a white or almost white powder that exhibits polymorphism. It is very slightly soluble in water or alcohol.

Uses

Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Preparation

Domperidone was synthesized at Janssen Pharmaceutica in 1974 following their research on antipsychotic drugs. The present invention relates to synthesis of domperidone maleate. O-diaminobenzene is first cyclized and halogenated to form the first benzimidazolone intermediate; 1-carbethoxy-4-amino piperidine is halogenated, reduced, cyclized and hydrolyzed to form the second benzimidazolone intermediate; the two benzimidazolone intermediates are reacted to produce domperidone; and domperidone is finally reacted with maleic aicd to produce domperidone maleate.
https://patents.google.com/patent/CN1810805A/en

Indications

Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition.

Side effects

Because plasma prolactin levels may be increased, galactorrhea or gynecomastia may result. Injectable products (now withdrawn) have been associated with arrhythmias in human patients with heart disease or hypokalemia. Rarely, somnolence or dystonic reac- tions have occurred in people.

Domperidone maleate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Domperidone maleate Suppliers

China 56 Europe 1 France 1 Germany 2 India 11 South Korea 1 United Kingdom 1 United States 6 Global 79

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 997
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4943
Advantage: 58

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: sales@dolonchem.com
Country: China
ProdList: 2331
Advantage: 50

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 2002
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 4032
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9578
Advantage: 60

Jiangsu United-value International Trading Co., Ltd.

Tel: 0519-89885611 89885616 15312500313
Fax: +86(519)89885615
Email: luke.li@uvcs.cn.com
Country: China
ProdList: 469
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Shenzhen Nangang Hengshun Trade Co. Ltd.

Tel: 15842340336
Email: yoyo@advtechind.com
Country: CHINA
ProdList: 98
Advantage: 58

Hubei Xingyinhe Chemical Co., Ltd.

Tel: 13307112120
Email: 1506207717@qq.com
Country: CHINA
ProdList: 630
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Xi'an ZB Biotech Co.,Ltd

Tel
Email: sales03@xazbbio.com
Country: CHINA
ProdList: 719
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hubei Jinsuo Biological Technology Co., Ltd.

Tel: 00123456789
Email: hubeijinsuo@163.com
Country: China
ProdList: 1547
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1907
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49476
Advantage: 58

Nanjing Shizhou Biotechnology Co., Ltd

Tel: 025-85563444 15850508050
Fax: 18013869214
Email: rose.shi@synzest.com
Country: China
ProdList: 271
Advantage: 58

Neostar United (Changzhou) Industrial Co., Ltd.

Tel: +86-0519-85551759 +8613506123987
Fax: +0086-519-85557389
Email: marketing1@neostarunited.com
Country: China
ProdList: 8840
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81024372 15029046529
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Nanjing Shizhou Biotechnology Co., Ltd

Tel: +86-15850508050 +86-15850508050
Fax: (+86)25-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 323
Advantage: 58

Chongqing Kangzhou Zhitong Pharmaceutical Technology Co., Ltd.

Tel: 173-08362167 17308362167
Email: 3090602484@qq.com
Country: China
ProdList: 568
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 10784
Advantage: 58

Henan Lavoisier Chemical Products Co. Ltd

Tel: 0371-63682289 18625781376
Fax: 18625781376
Email: jacschem@163.com
Country: China
ProdList: 5010
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44457
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 027-59222918 13385289472
Email: Z13385289472@163.com
Country: China
ProdList: 4922
Advantage: 58

Jiangsu Boquan Biotechnology Co., Ltd.

Tel: 15252131412; 15252131412
Email: 5954981@qq.com
Country: China
ProdList: 2965
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10674
Advantage: 58

Hubei Enxing Biotechnology Co., Ltd

Tel: 16621771607
Email: exbio_tech@163.com
Country: China
ProdList: 8189
Advantage: 58

Guangzhou Nalong Chemical Co.Ltd

Tel: 13192879270; 13192879270
Email: 1525037351@qq.com
Country: China
ProdList: 3498
Advantage: 58

Shenzhen Xingkaiyue Biotechnology Co. , Ltd.

Tel: 0755-18589069862 18589069862
Email: 1158168052@qq.com
Country: China
ProdList: 1000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 18021050169
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 15620
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11183
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: 18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 591
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21632
Advantage: 55

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Country: China
ProdList: 29871
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32965
Advantage: 60

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

Tel: +86-19925801629 +86-19925801629
Email: eric@huarongpharma.com
Country: China
ProdList: 242
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33338
Advantage: 58

Nanjing Dolon Biotechnology Co.,Ltd.

Tel: 18905173768
Email: sales@dolonchem.com
Country: CHINA
ProdList: 2972
Advantage: 58

Shanghai Xiyuan Biotechnology Co., Ltd

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6934
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Less

View Lastest Price from Domperidone maleate manufacturers

Career Henan Chemical Co

Product: Domperidone maleate 99497-03-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 683
Release date: 2019-09-01

99497-03-7, Domperidone maleateRelated Search:

Domperidone Epichlorohydrin Allyl chloride Benzimidazole Enalapril maleate Propyl butyrate Chloromethyl isopropyl carbonate Tetrapropylammonium hydroxide Phenformin 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Disodium fumarate Propyl gallate DoMperidone EP IMpurity B DoMperidone-d6 Domperidone Impurity 15 1-(3-chloropropyl)-1,3-dihydro-3-(1-methylvinyl)-2H-benzimidazol-2-one 1-(3-BroMopropyl)-1,3-dihydro-2H-benziMidazol-2-one 1-PIPERIDINECARBOXYLIC ACID, 4-[(4-AMINO-5-CHLOROPHENYL)AMINO], ETHYL ESTER

DOMPERIDONE MALEATE

5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate

2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate

E-Domperidone Maleate

6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one

(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one

Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate

Domperidone Maleate IP/BP/Ph. Eur

DOMEPRIDONE MALEATE

Domperidone maleate((1:X)

99497-03-7

C22H24ClN5O2C4H4O4

C26H28ClN5O6