Brivanib

Product Name: Brivanib
CAS No.: 649735-46-6
Chemical Name: Brivanib
Synonyms: CS-75;Brivanib;Bms540215;Bms 540215;Unii-ddu33B674i;Brivanib, >=98%;Brivanib(BMS-540215);BMS540215; BMS 540215;Tyrosine Kinase Inhibitor;Brivanib/Tyrosine Kinase Inhibitor
CBNumber: CB92484687
Molecular Formula: C19H19FN4O3
Formula Weight: 370.38
MOL File: 649735-46-6.mol

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Brivanib Property

Density: 1.42
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥18.5 mg/mL in DMSO; ≥3.39 mg/mL in EtOH with ultrasonic
form: Yellow powder.
pka: 14.18±0.20(Predicted)
color: White to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3671
Product name: Brivanib
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3671
Product name: Brivanib
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 23690
Product name: Brivanib
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23690
Product name: Brivanib
Purity: ≥95%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 23690
Product name: Brivanib
Purity: ≥95%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

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Brivanib Chemical Properties,Usage,Production

Uses

Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.

Definition

ChEBI: Brivanib is a secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an angiogenesis inhibitor, an apoptosis inducer, a fibroblast growth factor receptor antagonist and a drug metabolite. It is a pyrrolotriazine, a fluoroindole, a diether, an aromatic ether and a secondary alcohol.

Biological Activity

brivanib is an atp competitive inhibitor of human vegfr-2 with ic50 value of 25nm [1].brivanib is a selective rtk inhibitor that targets signaling via vegfr2 and 3, and fgfr1, 2 and 3. targeting both vegf and fgf signaling pathways inhibits tumor growth in rt2 mice, with vegf signaling predominating in initiation of tumor angiogenesis, currently, brivanib therapy is being evaluated in phase iii

target

VEGFR-2

References

[1] rajeev s. bhide, zhen-wei cai, yong-zheng zhang, ligang qian, donna wei, stephanie barbosa, louis j. lombardo, robert m. borzilleri, xiaoping zheng, laurence i. wu, joel c. barrish, soong-hoon kim, kenneth leavitt, arvind mathur, leslie leith, sam chao, barri wautlet, steven mortillo, robert jeyaseelan sr., daniel kukral, john t. hunt, amrita kamath, aberra fura, viral vyas, punit marathe, celia d’arienzo, george derbin, and joseph fargnoli. discovery and preclinical studies of (r)-1-(4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (bms-540215), an in vivo active potent vegfr-2 inhibitor. journal of medicinal chemistry. 2006, 49 (7): 2143-2146.
[2] elizabeth allen, ian b. walters, and douglas hanahan. brivanib, a dual fgf/vegf inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to vegf inhibition. clinical cancer research. 2011 (17): 5299-5310.

Brivanib Preparation Products And Raw materials

Raw materials

Preparation Products

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Brivanib Suppliers

China 132 India 5 United Kingdom 2 United States 18 Global 157

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

ApexBio Technology

Tel: --
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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Creative Enzymes

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Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

Matrix Scientific

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Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Selleck Chemicals LLC

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Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

Santa Cruz Biotechnology, Inc.

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Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Exlcusive Chemistry Ltd

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Country: United States
ProdList: 446
Advantage: 71

AK Scientific, Inc.

Tel: --
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Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

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View Lastest Price from Brivanib manufacturers

Career Henan Chemical Co

Product: 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol 649735-46-6
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

649735-46-6, BrivanibRelated Search:

Genistein Dasatinib Ruxolitinib CHLOROQUINE Icotinib Vandetanib Sorafenib Imatinib mesylate Gefitinib Bevacizumab TYROSINASE Boc-D-Tyr-OH PP242 Sorafenib tosylate GSK2636771 Brivanib alaninate Afatinib Lapatinib Ditosylate Tyrosine Kinase Inhibitor

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol

(R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yloxy)propan-2-ol

2-Propanol, 1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-, (2R)-

Bms 540215

Bms540215

Unii-ddu33B674i

1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-propan-2(R)-ol

(R)-1-(4-(4-Fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol

Brivanib(BMS-540215)

Brivanib

Tyrosine Kinase Inhibitor

(R)-1-(4-(4-fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol, BSM-540215

(2R)-1-[4-(4-Fluoro-2-Methyl-1H-indol-5-yloxy)-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol

(2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol

(2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypr

Brivanib, >=98%

(2R)-1-[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]ox

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-yl]oxy]-2

CS-75

BMS540215; BMS 540215

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol USP/EP/BP

(2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpy...

Brivanib/Tyrosine Kinase Inhibitor

649735-46-6

Inhibitors