ChemicalBook > CAS DataBase List > 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

Product Name
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
CAS No.
3543-74-6
Chemical Name
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Synonyms
Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A
CBNumber
CB92485093
Molecular Formula
C18H27N3O4
Formula Weight
349.42
MOL File
3543-74-6.mol
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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Property

Melting point:
98-101°C
Boiling point:
580.6±50.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.26±0.10(Predicted)
color 
White to Brown
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Safety

HS Code 
2933998350
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1065254
Product name
Bendamustine Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20MG
Price
$3470
Updated
2024/03/01
TRC
Product number
M294190
Product name
[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoicAcidEthylEster
Packaging
500mg
Price
$275
Updated
2021/12/16
AK Scientific
Product number
J11386
Product name
BendamustineImpurity1
Packaging
25mg
Price
$49
Updated
2021/12/16
AK Scientific
Product number
J11386
Product name
BendamustineImpurity1
Packaging
100mg
Price
$148
Updated
2021/12/16
AK Scientific
Product number
J97550
Product name
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoicacidethylester
Packaging
5g
Price
$210
Updated
2021/12/16
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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Usage,Production

Chemical Properties

Off-White to Light Tan Solid

Uses

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.

Synthesis

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%.

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers

Canada 1 China 157 Germany 1 India 17 United States 7 Global 183
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers

Henan Fengda Chemical Co., Ltd
Product
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6
Price
US $32.00-1.30/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Career Henan Chemical Co
Product
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-07-01

3543-74-6, 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl esterRelated Search:

Bendamustine Impurity 26 FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Desmethyl Impurity Bendamustine Ether Impurity Bendamustine Impurity 28 DesMethyl BendaMustine Hydrochloride BendaMustine IMpurity B 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Bendamustine Impurity 8 Bendamustine Impurity D 5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Bendamustine Impurity 14 BendaMustine IMpurity C　　 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid

  • Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate
  • 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester
  • 4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
  • ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate
  • Bendamustine Related Impurity 1
  • 1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester
  • 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
  • 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester
  • 1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester
  • 5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est
  • Bendamustine hydrochloride Intermediates 1
  • Bendamustine Dihydroxy Ester
  • [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related
  • ethyl 4-(5-(bis(2-hydroxyethyl)amino)
  • Bendamustine USP RC C
  • Bendamustine USP Related Compound C
  • Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate
  • 5-[Bis(2-hydroxyethyl)amino]-1-meth
  • Bendamustine Impurity 40
  • Bendamustine USP RC C /Bendamustine Impurity A
  • Bendamustine Related Compound C
  • [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano...
  • 5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel
  • Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate
  • Bendamustin Impurity-A (USP related compound C)
  • 3543-74-6
  • 543-74-6
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  • Aromatics
  • Intermediates & Fine Chemicals
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