5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

Product Name: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
CAS No.: 3543-74-6
Chemical Name: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Synonyms: Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A
CBNumber: CB92485093
Molecular Formula: C18H27N3O4
Formula Weight: 349.42
MOL File: 3543-74-6.mol

More

Less

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Property

Melting point:: 98-101°C
Boiling point:: 580.6±50.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.26±0.10(Predicted)
color: White to Brown

More

Less

Safety

HS Code: 2933998350

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1065254
Product name: Bendamustine Related Compound C
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20MG
Price: $3470
Updated: 2024/03/01

TRC

Product number: M294190
Product name: [1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoicAcidEthylEster
Packaging: 500mg
Price: $275
Updated: 2021/12/16

AK Scientific

Product number: J97550
Product name: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoicacidethylester
Packaging: 5g
Price: $210
Updated: 2021/12/16

AK Scientific

Product number: J11386
Product name: BendamustineImpurity1
Packaging: 25mg
Price: $49
Updated: 2021/12/16

AK Scientific

Product number: J11386
Product name: BendamustineImpurity1
Packaging: 100mg
Price: $148
Updated: 2021/12/16

More

Less

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Usage,Production

Chemical Properties

Off-White to Light Tan Solid

Uses

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.

Synthesis

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%.

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers

Canada 1 China 157 Germany 1 India 17 United States 7 Global 183

VIVAN Life Sciences Pvt. Limited.

Tel: --
Fax: --
Email: info@vivanls.com
Country: India
ProdList: 138
Advantage: 50

Manus Aktteva

Tel: --
Fax: --
Email: info@manusaktteva.in
Country: India
ProdList: 581
Advantage: 34

KKyemistry (India) Pvt. Ltd.

Tel: --
Fax: --
Email: info@kyemistryindia.com
Country: India
ProdList: 197
Advantage: 50

Olympus Chemicals & Fertilizers

Tel: --
Fax: --
Country: India
ProdList: 486
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

RXN Chemicals Private Limited

Tel: --
Fax: --
Country: India
ProdList: 137
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

SynZeal Research Pvt Ltd

Tel: --
Fax: --
Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

Trignokem International

Tel: --
Fax: --
Email: info@trignokem.com
Country: India
ProdList: 380
Advantage: 50

More

Less

View Lastest Price from 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers

Henan Fengda Chemical Co., Ltd

Product: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6
Price: US $32.00-1.30/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

Career Henan Chemical Co

Product: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-01

3543-74-6, 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl esterRelated Search:

Bendamustine Impurity 26 FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Desmethyl Impurity Bendamustine Ether Impurity Bendamustine Impurity 28 DesMethyl BendaMustine Hydrochloride BendaMustine IMpurity B 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Bendamustine Impurity 8 Bendamustine Impurity D 5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Bendamustine Impurity 14 BendaMustine IMpurity C　　 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid

Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate

5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester

4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester

ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate

Bendamustine Related Impurity 1

1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester

1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester

5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est

Bendamustine hydrochloride Intermediates 1

Bendamustine Dihydroxy Ester

[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related

ethyl 4-(5-(bis(2-hydroxyethyl)amino)

Bendamustine USP RC C

Bendamustine USP Related Compound C

Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate

5-[Bis(2-hydroxyethyl)amino]-1-meth

Bendamustine Impurity 40

Bendamustine USP RC C /Bendamustine Impurity A

Bendamustine Related Compound C

[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano...

5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel

Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate

Bendamustin Impurity-A (USP related compound C)

3543-74-6

543-74-6

intermediate

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals