ChemicalBook > CAS DataBase List > 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
- Product Name
- 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
- CAS No.
- 3543-74-6
- Chemical Name
- 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
- Synonyms
- Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A
- CBNumber
- CB92485093
- Molecular Formula
- C18H27N3O4
- Formula Weight
- 349.42
- MOL File
- 3543-74-6.mol
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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Property
- Melting point:
- 98-101°C
- Boiling point:
- 580.6±50.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.26±0.10(Predicted)
- color
- White to Brown
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Safety
- HS Code
- 2933998350
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 1065254
- Product name
- Bendamustine Related Compound C
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20MG
- Price
- $3470
- Updated
- 2024/03/01
TRC
- Product number
- M294190
- Product name
- [1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoicAcidEthylEster
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
AK Scientific
- Product number
- J97550
- Product name
- 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoicacidethylester
- Packaging
- 5g
- Price
- $210
- Updated
- 2021/12/16
AK Scientific
- Product number
- J11386
- Product name
- BendamustineImpurity1
- Packaging
- 25mg
- Price
- $49
- Updated
- 2021/12/16
AK Scientific
- Product number
- J11386
- Product name
- BendamustineImpurity1
- Packaging
- 100mg
- Price
- $148
- Updated
- 2021/12/16
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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Usage,Production
Chemical Properties
Off-White to Light Tan Solid
Uses
[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.
Synthesis
Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%.
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6
- Price
- US $32.00-1.30/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28
Career Henan Chemical Co
- Product
- 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-01
3543-74-6, 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl esterRelated Search:
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BEPOTASTINE BESILATE
5-alpha-Hydroxy- Laxogenin
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate
Bendamustine Desmethyl Impurity
Bendamustine Ether Impurity
Bendamustine Impurity 28
DesMethyl BendaMustine Hydrochloride
BendaMustine IMpurity B
5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid
Bendamustine Impurity 8
Bendamustine Impurity D
5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Bendamustine Impurity 14
BendaMustine IMpurity C
5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid